1H NMR study of the effect of cucurbit[7]uril on the aquation of carboplatin in biologically relevant media

The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin

“…Perhaps the synergistic effect is caused by higher toxicity of CB[7] complexes with products of the aquation of carboplatin, which are formed in vivo. During aquation, carboplatin decomposes into 1,1-cyclobutanedicarboxylic acid and cis-PtL 2 (NH 3 ) 2 (L = H 2 O or OH − ), so it loses the leaving group and forms an inclusion complex with CB[7] [ 23 ]. Loss of the leaving group can increase the reactivity rate of products of the aquation of carboplatin with nucleophiles.…”

“…However, interaction of CB [7] with carboplatin provokes aquation of the latter, and one of the products of this process forms a complex with CB [7]. As we found earlier, CB [7] induces the aquation of carboplatin with the formation of CB [7] inclusion complex with one of the aquation products [21][22][23]. This process differs in PBS buffer solution and RPMI-1640 medium, because CB [7] could bind to some components of the media, such as amino acids or proteins.…”

Evaluation of the Immunosafety of Cucurbit[n]uril on Peripheral Blood Mononuclear Cells In Vitro

“…CB [n]s have a number of advantages, such as low toxicity, the ability to form stable complexes with various compounds, and the ability to bind with both hydrophobic and positively charged molecules. The formation of complexes of CB[n]s (n = 6, 7, and 8) with drugs can result in several benefits [3][4][5][6][7][8], including increasing the stability of the drug and reducing the rate of degradation in vivo, increased solubility, altered clearance, enabling a change in the route of administration (from parenteral to oral), and taste masking. The cavities of CB [6] and CB [7] (Figure S1 in Supplementary) are large enough to encapsulate transition metal complexes and small peptides [9].…”

“…Intravenous administration of CB[n] is limited because of the low solubility, and not because of the development of side effects. For oral administration of a mixture of CB [6]-CB [8], the maximum tolerated dose was 600 mg/kg [17]. In another study of the biocompatibility of CB [7], Zhang et al showed that a single oral dose of CB [7] at 5 g/kg did not lead to a significant decrease in animal body weight within 21 days after administration [22].…”