Antitumor activity of supramolecular complexes of cucurbituril with platinum(II) compounds

Pashkina, Ekaterina; Гришина, Л. В.; Aktanova, Alina; Козлов, В. А.

doi:10.1016/j.ica.2021.120370

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…It is observed from the table that the inner cavity diameter of CB[ n ] units ranges from 4.4 to 12.4 Å which is sufficient to accommodate tiny molecules or ions (Figure ). On the other hand, the larger homologues CB [7], CB [8], and CB [10] can trap bigger and more than one guest species in their cavity, thus the cavity volume, which changes with the ring size, is another essential factor affecting the properties of these supramolecules. , To improve the therapeutic efficacy, specificity, reliability, and diagnostic sensitivity, the top priority is the fabrication of supramolecular structures with well-controlled parameters such as size, shape, charge, payload, surface chemistry, and biostability. As these parameters are closely related to the second challenge related to determining the stability and biodistribution of supramolecular nanosystems, in vivo , after systemic administration.…”

Section: Introductionmentioning

confidence: 99%

Supramolecular Chemotherapy with Cucurbit[n]urils as Encapsulating Hosts

Shukla

Sagar

Sood

et al. 2023

ACS Appl. Bio Mater.

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The cucurbit[n]urils (CB[n]) belong to the field of relatively young supramolecules which act as containers for a large variety of guests and are being explored extensively for their numerous biomedical applications. This includes drug formulation and delivery, controlled drug release, photodynamic therapy, sensing for bioanalytical purposes, etc. These supramolecular host–guest systems have distinctive recognition properties and have successfully been shown to enhance the in vitro and in vivo utility of various chemotherapeutic agents. The CB[n]s are tailored to optimize their application in payload delivery and diagnostics and in lowering the toxicity of existing drugs. This review has listed the recent studies on working mechanisms and host–guest complexation of the biologically vital molecules with CB[n] and highlighted their implementation in anticancer therapeutics. Various modifications in CB-drug inclusion compounds like CB supramolecular nanoarchitectures along with application in photodynamic therapy, which has shown potential as targeted drug delivery vehicles in cancer chemotherapy, have also been discussed.

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Section: Introductionmentioning

confidence: 99%

Supramolecular Chemotherapy with Cucurbit[n]urils as Encapsulating Hosts

Shukla

Sagar

Sood

et al. 2023

ACS Appl. Bio Mater.

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“…Indeed, they are now widely used in sensing, drug delivery, nanomaterials and other fields. [15][16][17][18][19] However, several inherent disadvantages of Q[n]s hinder their wider development and application. Firstly, Q[n]s do not possess any absorption or fluorescence in the visible region.…”

Section: Introductionmentioning

confidence: 99%

A cucurbit[6]uril-carbon dot system: a potentially new bioimaging agent

Zhang

Tian

Liu

et al. 2022

Mater. Chem. Front.

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“…A particular research interest is focused on complexes of CB [n] with anticancer drugs based on metal complexes, primarily platinum (II). It is known that CB [7] forms complexes with various platinum compounds, and complexation can enhance the antitumor effect of the drug and reduce side effects [11].The most studied system of this type is the complex of CB [7] (Figure 1) with cisplatin [12]. In vivo studies have shown that the complexation with CB[n] reduces the toxic side effects of cisplatin [13,14].…”

Section: Introductionmentioning

confidence: 99%

The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin

Pashkina

Aktanova

Mirzaeva

et al. 2021

IJMS

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Cucurbit[7]uril (CB[7]) is a molecular container that may form host–guest complexes with platinum(II) anticancer drugs and modulate their efficacy and safety. In this paper, we report our studies of the effect of CB[7]–oxaliplatin complex and the mixture of CB[7] and carboplatin (1:1) on viability and proliferation of a primary cell culture (peripheral blood mononuclear cells), two tumor cell lines (B16 and K562) and their activity in the animal model of melanoma. At the same time, we studied the impact of platinum (II) drugs with CB[7] on T cells and B cells in vitro. Although the stable CB[7]–carboplatin complex was not formed, the presence of cucurbit[7]uril affected the biological properties of carboplatin. In vivo, CB[7] increased the antitumor effect of carboplatin, but, at the same time, increased its acute toxicity. Compared to free oxaliplatin, its complex with CB[7] shows a greater cytotoxic effect on tumor cell lines B16 and K562, while in vivo, the effects of the free drug and encapsulated drug were comparable. However, in vivo studies also demonstrated that the encapsulation of oxaliplatin in CB[7] lowered the toxicity of the drug.

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Antitumor activity of supramolecular complexes of cucurbituril with platinum(II) compounds

Cited by 3 publications

References 46 publications

Supramolecular Chemotherapy with Cucurbit[n]urils as Encapsulating Hosts

Supramolecular Chemotherapy with Cucurbit[n]urils as Encapsulating Hosts

A cucurbit[6]uril-carbon dot system: a potentially new bioimaging agent

The Effect of Cucurbit[7]uril on the Antitumor and Immunomodulating Properties of Oxaliplatin and Carboplatin

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