19F NMR imaging of a fluorinated anesthetic in a model system

Wyrwicz, Alice M.; Ryback, Kenneth R.; Chew, Will; Hurd, Ralph E.

doi:10.1016/0022-2364(86)90178-2

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Cited by 3 publications

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In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

Albert¹,

Rembold²,

Kruppa³

et al. 1990

NMR in Biomedicine

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In vivo 19F NMR measurements of trifluorinated neuroleptics in the rat brain were made using a 13 x 18 mm surface coil at 4.7 T. The signal of fluphenazine was obtained within 8-15 min from brains of living rats treated chronically with drug doses of 5-30 mg/kg. Following the intravenous injection of a single dose of trifluoperazine (30 mg/kg), brain levels could be monitored with a time resolution of 30 min. The data demonstrate the possibility of obtaining in vivo pharmacokinetics of fluorinated agents in the rat brain. 19F NMR is expected to become an important tool in neurochemical research.

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In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

Albert¹,

Rembold²,

Kruppa³

et al. 1990

NMR in Biomedicine

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show abstract

In Vivo 19F NMR

Selinsky

Burt

1992

In Vivo Spectroscopy

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In vivo19F NMR chemical-shift imaging ofAncistrocladus species

et al. 2001

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19F nuclear magnetic resonance (NMR) imaging and 19F NMR chemical-shift imaging (19F CSI) have been used to localize fluorinated compounds administered to stems of Ancistrocladus heyneanus and A. abbreviatus for the elucidation of biosynthetic pathways in living plants. This first application of 19F CSI on plants proved CSI to be a valuable technique for mapping fluorinated molecules in plants. Exemplarily using trifluoroacetate as a model compound allowed to select appropriate feeding methods and to optimize both concentration and duration of the application to the plant. The time course of the uptake and distribution of trifluoroacetate was monitored by both 19F imaging and 19F CSI. Fluorinated metabolites formed by uptake of 3-fluoro-3-deoxy-D-glucose were detected with 19F CSI.

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19F NMR imaging of a fluorinated anesthetic in a model system

Cited by 3 publications

References 15 publications

In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

In Vivo 19F NMR

In vivo19F NMR chemical-shift imaging ofAncistrocladus species

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19F NMR imaging of a fluorinated anesthetic in a model system

Cited by 3 publications

References 15 publications

In vivo19F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

In vivo19F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

In Vivo 19F NMR

In vivo19F NMR chemical-shift imaging ofAncistrocladus species

Contact Info

Product

Resources

About

In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat

In vivo¹⁹F nuclear magnetic resonance spectroscopy of trifluorinated neuroleptics in the rat