In Vivo 19F NMR

Selinsky, Barry S.; Burt, C. Tyler

doi:10.1007/978-1-4757-9477-9_5

Cited by 9 publications

(6 citation statements)

References 100 publications

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“…In the past, various reviewers have discussed diverse applications of in vivo 19 F NMR [21,27,28,[33][34][35][36][37][38][39][40][41]. Thomas [33], Selinsky and Burt [34], Prior et al [35] and London [36] reviewed the contemporary state-of-the-art, covering the entire spectrum of in vivo applications. Mason reviewed the use of perfluorocarbons for measuring pO 2 [27,37] and the use of fluorinated derivatives of vitamin B 6 as probes for measuring in vivo cellular transmembrane pH gradients [28].…”

Section: Introductionmentioning

confidence: 99%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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Section: Introductionmentioning

confidence: 99%

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

View full text Add to dashboard Cite

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“…This is not surprising, considering the wide range of metabolites that can be measured with these nuclei. More detailed reviews on applications of in vivo 19 F MRS can be found in the literature [306][307][308]. Fluorine-19 (spin I = 1/2) is 100 % naturally abundant and has a NMR sensitivity of 83 % relative to protons.…”

Section: Fluorine-19 Nmr Spectroscopymentioning

confidence: 99%

In Vivo NMR Spectroscopy – Static Aspects

Graaf

Robin²

2007

In Vivo NMR Spectroscopy

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“…f ϭ r c T 10 /(1 ϩ r c T 10 ) ϭ 1ϪT 1 /T 10 [3] where r and c are the relaxivity and concentration of the contrast agent and T 10 and T 1 are the relaxation times of the nuclei in the absence and presence of the contrast agent, respectively. Since 19 F nuclei have longer T 10 than 1 H, the contribution from Eq.…”

Section: Theorymentioning

confidence: 99%

“…Since 19 F nuclei have longer T 10 than 1 H, the contribution from Eq. [3] to OE is expected to be larger for FEDRI.…”

Section: Theorymentioning

confidence: 99%