In vivo19F NMR chemical-shift imaging ofAncistrocladus species

Bringmann, Gerhard; Wolf, Kristina K.; Meininger, Martin; Rokitta, Markus; Haase, Axel

doi:10.1007/bf01306603

Cited by 10 publications

(3 citation statements)

References 30 publications

(14 reference statements)

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“…A large range results in less signal overlap in fluorine MR spectra and therefore in better differentiation of spectral peaks. 24 This figure shows the chemical structure (A), MR spectrum (B), and MR images (C) of 2 vials filled with different PFCs: PFOB, and PFCE. Perfluorooctyl bromide has 15 fluorine atoms, which are not chemically equivalent and therefore displays several resonance peaks (B), resulting in the so-called ghost artifacts (ie, object repetitions in the frequency-encode direction) on regular MR images (C).…”

Section: Emerging Clinical Fluorine Mr Applicationsmentioning

confidence: 98%

Clinical Perspectives of Hybrid Proton-Fluorine Magnetic Resonance Imaging and Spectroscopy

Wolters¹,

Mohades²,

Hackeng³

et al. 2013

Investigative Radiology

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The number of applications of fluorine 19 (19F) magnetic resonance (MR) imaging and spectroscopy in biomedical and clinical research is steadily growing. The 100% natural abundance of fluorine and its relatively high sensitivity for MR (83% to that of protons) make it an interesting nucleus for a wide range of MR applications. Fluorinated contrast media have a number of advantages over the conventionally used gadolinium-based or iron-based contrast agents. The absence of an endogenous fluorine background intensity in the human body facilitates reliable quantification of fluorinated contrast medium or drugs. Anatomy can be visualized separately with proton MR imaging, creating the application of hybrid hydrogen 1 (1H)/19F MR imaging. The availability of 2 channels (ie, the 1H and 19F channels) enables dual-targeted molecular imaging. Recently, novel developments have emerged on fluorine-based contrast media in preclinical studies and imaging techniques. The developments in fluorine MR seem promising for clinical applications, with contributions in therapy monitoring, assessment of lung function, angiography, and molecular imaging. This review outlines the translation from recent advances in preclinical MR imaging and spectroscopy to future perspectives of clinical hybrid 1H/19/F MR imaging applications.

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Section: Emerging Clinical Fluorine Mr Applicationsmentioning

confidence: 98%

Clinical Perspectives of Hybrid Proton-Fluorine Magnetic Resonance Imaging and Spectroscopy

Wolters¹,

Mohades²,

Hackeng³

et al. 2013

Investigative Radiology

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“…Application of 19F MRI in plants has up till now been limited to hydrophilic fluorinated molecules as model drugs such as trifluoroacetate. [ 48 ]…”

Section: In Planta Biodistributionmentioning

confidence: 99%

Targeted Drug Delivery for Sustainable Crop Protection: Transport and Stability of Polymeric Nanocarriers in Plants

et al. 2021

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Spraying of agrochemicals (pesticides, fertilizers) causes environmental pollution on a million‐ton scale. A sustainable alternative is target‐specific, on‐demand drug delivery by polymeric nanocarriers. Trunk injections of aqueous nanocarrier dispersions can overcome the biological size barriers of roots and leaves and allow distributing the nanocarriers through the plant. To date, the fate of polymeric nanocarriers inside a plant is widely unknown. Here, the in planta conditions in grapevine plants are simulated and the colloidal stability of a systematic series of nanocarriers composed of polystyrene (well‐defined model) and biodegradable lignin and polylactic‐co‐glycolic acid by a combination of different techniques is studied. Despite the adsorption of carbohydrates and other biomolecules onto the nanocarriers’ surface, they remain colloidally stable after incubation in biological fluids (wood sap), suggesting a potential transport via the xylem. The transport is tracked by fluorine‐ and ruthenium‐labeled nanocarriers inside of grapevines by 19F‐magnetic resonance imaging or induced coupled plasma – optical emission spectroscopy. Both methods show that the nanocarriers are transported inside of the plant and proved to be powerful tools to localize nanomaterials in plants. This study provides essential information to design nanocarriers for agrochemical delivery in plants to sustainable crop protection.

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“…This allows for unambiguous detection of many exogenously administered 19 F markers exhibiting unique spectral signals. These advantages, along with its gyromagnetic ratio comparable to 1 H, make fluorine a suitable marker for molecular imaging [2], cell tracking [1,3], and other biological and medical applications [4][5][6]. The identification of different 19 F markers can be achieved using chemical shift imaging (CSI) [2,7,8].…”

Section: Introductionmentioning

confidence: 99%