Application of compressed sensing to in vivo 3D 19F CSI

Kampf, Thomas; Fischer, André; Basse-Lüsebrink, Thomas C.; Ladewig, Gesa; Breuer, Felix; Stoll, Guido; Jakob, Peter M.; Bauer, Wolfgang R.

doi:10.1016/j.jmr.2010.09.006

Cited by 42 publications

(63 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[32][33][34][35][36] However, these studies used a chemical shift imaging (CSI) approach with bSSFP to allow for visualization of the different spatial distributions of chemically shifted PFC compounds. Overall, the vast majority of studies that perform cell tracking with 19 F MRI have employed spin echo sequences.…”

Section: Cell Detection With Bssfpmentioning

confidence: 99%

In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence

Ribot¹,

Gaudet²,

Chen³

et al. 2014

IJN

View full text Add to dashboard Cite

Mesenchymal stem cells (MSC) are used to restore deteriorated cell environments. There is a need to specifically track these cells following transplantation in order to evaluate different methods of implantation, to follow their migration within the body, and to quantify their accumulation at the target. Cellular magnetic resonance imaging (MRI) using fluorine-based nanoemulsions is a great means to detect these transplanted cells in vivo because of the high specificity for fluorine detection and the capability for precise quantification. This technique, however, has low sensitivity, necessitating improvement in MR sequences. To counteract this issue, the balanced steady-state free precession (bSSFP) imaging sequence can be of great interest due to the high signal-to-noise ratio (SNR). Furthermore, it can be applied to obtain 3D images within short acquisition times. In this paper, bSSFP provided accurate quantification of samples of the perfluorocarbon Cell Sense-labeled cells in vitro. Cell Sense was internalized by human MSC (hMSC) without adverse alterations in cell viability or differentiation into adipocytes/osteocytes. The bSSFP sequence was applied in vivo to track and quantify the signals from both Cell Sense-labeled and iron-labeled hMSC after intramuscular implantation. The fluorine signal was observed to decrease faster and more significantly than the volume of iron-associated voids, which points to the advantage of quantifying the fluorine signal and the complexity of quantifying signal loss due to iron.

show abstract

Section: Cell Detection With Bssfpmentioning

confidence: 99%

In vivo MR detection of fluorine-labeled human MSC using the bSSFP sequence

Ribot¹,

Gaudet²,

Chen³

et al. 2014

IJN

View full text Add to dashboard Cite

show abstract

“…It has been under development since 2006 [20] and has been successfully applied to proton and 3 He MRI [21–23], 13 C and 19 F spectroscopy [24, 25], and to microfluidic flow imaging [26], as well as to combined time/k-space domain imaging [27–29]. CS is based on the sparsity (or compressibility) of the image in any known transform domain, the incoherence of the undersampling artifacts, and a dedicated nonlinear reconstruction algorithm.…”

Section: Introductionmentioning

confidence: 99%

Compressed sensing sodium MRI of cartilage at 7T: Preliminary study

Madelin

Chang

Otazo

et al. 2012

Journal of Magnetic Resonance

View full text Add to dashboard Cite

Sodium MRI has been shown to be highly specific for glycosaminoglycan (GAG) content in articular cartilage, the loss of which is an early sign of osteoarthritis (OA). Quantitative sodium MRI techniques are therefore under development in order to detect and assess early biochemical degradation of cartilage, but due to low sodium NMR sensitivity and its low concentration, sodium images need long acquisition times (15 to 25 min) even at high magnetic fields and are typically of low resolution. In this preliminary study, we show that compressed sensing can be applied to reduce the acquisition time by a factor of 2 at 7T without losing sodium quantification accuracy. Alternatively, the nonlinear reconstruction technique can be used to denoise fully-sampled images. We expect to even further reduce this acquisition time by using parallel imaging techniques combined with SNR-improved 3D sequences at 3T and 7T.

show abstract

“…A new approach for accelerated imaging is compressed sensing, whereby sparse signals may be adequately detected despite under sampling [177]. Despite apparent conflict with the Nyquist requirements, robust investigation in terms of spatial distribution and spectral resolution is widely reported for proton MRI and recent examples show accelerated 19 F MRI [178, 179]. …”

Section: Innovations and Enhancementsmentioning

confidence: 99%