18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis

Kitagawa, Toshiro; Yamamoto, Hideya; Toshimitsu, Shinya; Sasaki, Ko; Senoo, Atsuhiro; Kubo, Yoshiko; Tatsugami, Fuminari; Awai, Kazuo; Hirokawa, Yutaka; Kihara, Yasuki

doi:10.1016/j.atherosclerosis.2017.04.024

Cited by 52 publications

(28 citation statements)

References 29 publications

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“…1–4 However, imaging of the coronary arteries faces many challenges. First, the small caliber of coronary vessels combined with their tortuous course means that optimizing spatial resolution is of great importance.…”

Section: Introductionmentioning

confidence: 99%

Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Doris

Otaki

Krishnan

et al. 2020

Journal of Nuclear Cardiology

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Section: Introductionmentioning

confidence: 99%

Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Doris

Otaki

Krishnan

et al. 2020

Journal of Nuclear Cardiology

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“…14,15 The use of [ 18 F]-FDG PET for AAA imaging is therefore limited, with potential confounding factors and lack of specificity, thereby raising concerns about its future clinical use in predicting potential AAA expansion and risk of rupture. 14,15 Nevertheless, an alternative PET radiotracer, [ 18 F]-NaF, is currently being explored as a marker for microcalcification in the cardiovascular system [16][17][18] and has been used to investigate coronary atherosclerosis, 19,20 abdominal atherosclerosis, 21 aortic stenosis 22,23 and AAA diseases. 24 Preliminary investigation 24 shows that this tracer is promising for improved prediction of AAA disease progression, and may therefore facilitate early intervention for those at higher risk of rupture.…”

Section: Introductionmentioning

confidence: 99%

“…However, a major confounding issue is the artificial spill in contamination from the bone into the aneurysm due to the limited PET resolution and the associated partial volume effect. [ 18 F]-NaF is predominantly taken up by bone, 19,20,24 thus the AAA regions in close proximity to the bones have considerably higher uptake than more distal regions. 24 Common conventional techniques to mitigate the spill in contamination include masking out the high uptake region in the image space, or simply excluding areas of spill in from regions of interest during image analysis.…”

Section: Introductionmentioning

confidence: 99%

Iterative reconstruction incorporating background correction improves quantification of [18F]-NaF PET/CT images of patients with abdominal aortic aneurysm

Akerele

Karakatsanis

Forsythe

et al. 2021

Journal of Nuclear Cardiology

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Background. A confounding issue in [ 18 F]-NaF PET/CT imaging of abdominal aortic aneurysms (AAA) is the spill in contamination from the bone into the aneurysm. This study investigates and corrects for this spill in contamination using the background correction (BC) technique without the need to manually exclude the part of the AAA region close to the bone. Methods. Seventy-two (72) datasets of patients with AAA were reconstructed with the standard ordered subset expectation maximization (OSEM) algorithm incorporating point spread function (PSF) modelling. The spill in effect in the aneurysm was investigated using two target regions of interest (ROIs): one covering the entire aneurysm (AAA), and the other covering the aneurysm but excluding the part close to the bone (AAA exc). ROI analysis was performed by comparing the maximum SUV in the target ROI (SUV max (T)), the corrected cSUV max (SUV max (T) 2 SUV mean (B)) and the target-to-blood ratio (TBR = SUV max (T)/SUVmean (B)) with respect to the mean SUV in the right atrium region.

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“…The preferential binding of 18 F-NaF uptake to microcalcification is also explained by high surface area of hydroxyapatite in microcalcifications compared to large macroscopic calcifications where hydroxyapatite is internalized and not available for binding [97]. This discordance between morphologic and nuclear imaging provide complementary information and may improve differentiating stable from vulnerable plaques [98,99].…”

Section: Positron Emission Tomography (Pet)mentioning

confidence: 99%

Coronary Atherosclerosis Imaging

et al. 2020

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Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention. Imaging techniques provide direct assessment of coronary atherosclerotic burden and pathological characteristics of atherosclerotic lesions which may predict the progression of disease. Atherosclerosis imaging has been traditionally based on the evaluation of coronary luminal narrowing and stenosis. However, the degree of arterial obstruction is a poor predictor of subsequent acute events. More recent techniques focus on the high-resolution visualization of the arterial wall and the coronary plaques. Most acute coronary events are triggered by plaque rupture or erosion. Hence, atherosclerotic plaque imaging has generally focused on the detection of vulnerable plaque prone to rupture. However, atherosclerosis is a dynamic process and the plaque morphology and composition may change over time. Most vulnerable plaques undergo progressive transformation from high-risk to more stable and heavily calcified lesions, while others undergo subclinical rupture and healing. Although extensive plaque calcification is often associated with stable atherosclerosis, the extent of coronary artery calcification strongly correlates with the degree of atherosclerosis and with the rate of future cardiac events. Inflammation has a central role in atherogenesis, from plaque formation to rupture, hence in the development of acute coronary events. Morphologic plaque assessment, both invasive and non-invasive, gives limited information as to the current activity of the atherosclerotic disease. The addition of nuclear imaging, based on radioactive tracers targeted to the inflammatory components of the plaques, provides a highly sensitive assessment of coronary disease activity, thus distinguishing those patients who have stable disease from those with active plaque inflammation.

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18F-sodium fluoride positron emission tomography for molecular imaging of coronary atherosclerosis based on computed tomography analysis

Cited by 52 publications

References 29 publications

Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Iterative reconstruction incorporating background correction improves quantification of [18F]-NaF PET/CT images of patients with abdominal aortic aneurysm

Coronary Atherosclerosis Imaging

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