Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Doris, Mhairi; Otaki, Yuka; Krishnan, Sandeep; Kwieciński, Jacek; Rubeaux, Mathieu; Alessio, Adam M.; Pan, Tinsu; Cadet, Sebastien; Dey, Damini; Dweck, Marc R; Newby, David E.; Berman, Daniel S.; Slomka, Piotr J.

doi:10.1007/s12350-018-1317-5

Cited by 44 publications

(104 citation statements)

References 17 publications

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“…A more in-depth discussion of quantification methods is beyond the scope of this article. Instead, readers are referred to articles dealing with such topic [16,[26][27][28][29][52][53][54][55][56][57].…”

Section: Methodsmentioning

confidence: 99%

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Høilund‐Carlsen

Sturek

Alavi

et al. 2019

Eur J Nucl Med Mol Imaging

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Purpose We examined the literature to elucidate the role of 18F-sodium fluoride (NaF)-PET in atherosclerosis. Methods Following a systematic search of PubMed/MEDLINE, Embase, and Cochrane Library included articles underwent subjective quality assessment with categories low, medium, and high. Of 2811 records, 1780 remained after removal of duplicates. Screening by title and abstract left 41 potentially eligible full-text articles, of which 8 (about the aortic valve (n = 1), PET/ MRI feasibility (n = 1), aortic aneurysms (n = 1), or quantification methodology (n = 5)) were dismissed, leaving 33 published 2010-2012 (n = 6), 2013-2015 (n = 11), and 2016-2018 (n = 16) for analysis. Results They focused on coronary (n = 8), carotid (n = 7), and femoral arteries (n = 1), thoracic aorta (n = 1), and infrarenal aorta (n = 1). The remaining 15 studies examined more than one arterial segment. The literature was heterogeneous: few studies were designed to investigate atherosclerosis, 13 were retrospective, 9 applied both FDG and NaF as tracers, 24 NaF only. Subjective quality was low in one, medium in 13, and high in 19 studies. The literature indicates that NaF is a very specific tracer that mimics active arterial wall microcalcification, which is positively associated with cardiovascular risk. Arterial NaF uptake often presents before CT-calcification, tends to decrease with increasing density of CT-calcification, and appears, rather than FDG-avid foci, to progress to CT-calcification. It is mainly surface localized, increases with age with a wide scatter but without an obvious sex difference. NaF-avid microcalcification can occur in fatty streaks, but the degree of progression to CT-calcification is unknown. It remains unknown whether medical therapy influences microcalcification. The literature held no therapeutic or randomized controlled trials. Conclusion The literature was heterogeneous and with few clear cut messages. NaF-PET is a new approach to detect and quantify microcalcification in early-stage atherosclerosis. NaF uptake correlates with cardiovascular risk factors and appears to be a good measure of the body's atherosclerotic burden, potentially suited also for assessment of anti-atherosclerotic therapy.

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Section: Methodsmentioning

confidence: 99%

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Høilund‐Carlsen

Sturek

Alavi

et al. 2019

Eur J Nucl Med Mol Imaging

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“…Motion correction of the aortic valve improves signal to noise ration and tissue-tobackground ratio compared to current standard approaches 15 Coronary motion correction technology improves image noise and improves lesion tissue-tobackground ratios 16,17 Partial volume effect correction of atherosclerotic lesions improves tissue-to-background ratios 18 Compensation for patient motion improves coronary lesion tissue-to-background ratios 19 Compensation for respiratory motion, cardiac motion and gross patient motion improves testretest reproducibility of coronary analysis 20 The current study shows that background correction of vertebral 18 F-NaF activity omits the requirement for manual exclusion of vertebral radiotracer activity from aortic analysis 5 unexpected finding. Regions of low or absent radiotracer activity may have arbitrary readings when quantified using standardized methods such as the maximum tissue-to-background ratio, in part due to the disproportionate effects of small variations in blood pool activity among other factors.…”

Section: Reconstruction Methods To Improve Analysis Of Arterial 18 F-mentioning

confidence: 99%

Optimizing arterial 18F-sodium fluoride positron emission tomography analysis

Bellinge

Schultz

2021

Journal of Nuclear Cardiology

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“…These techniques have focused on optimizing image reconstruction and correcting for cardiac, respiratory and gross patient motion, with the important advantage that they can be applied retrospectively to PET datasets. [37][38][39] Newer data have also demonstrated the feasibility of fusing PET data with previously acquired CTCA, expanding the potential practical application of this form of imaging. 40 18F-NaF PET-MR is also possible, with the benefit of lower doses of ionising radiation, but cannot currently provide the spatial resolution of CTCA for coronary artery imaging.…”

Section: Positron Emission Tomography: 18f-sodium Fluoridementioning

confidence: 99%

The clinical utility of hybrid imaging for the identification of vulnerable plaque and vulnerable patients

Bing

Driessen

Knaapen

et al. 2019

Journal of Cardiovascular Computed Tomography

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A R T I C L E I N F O Keywords: Vulnerable plaque Atherosclerosis Computed tomography coronary angiography Myocardial perfusion Positron emission tomography Fractional flow reserve Coronary physiology A B S T R A C TDespite decades of research and major innovations in technology, cardiovascular disease remains the leading cause of death globally. Our understanding of major cardiovascular events and their prevention is centred around the atherosclerotic plaque and the processes that ultimately lead to acute plaque rupture. Recent advances in hybrid imaging technology allow the combination of high spatial resolution and anatomical detail with molecular assessments of disease activity. This provides the ability to identify vulnerable plaque characteristics and differentiate active and quiescent disease, with the potential to improve patient risk stratification. Combined positron emission tomography and computed tomography is the prototypical non-invasive hybrid imaging technique for coronary artery plaque assessment. In this review we discuss the current state of play in the field of hybrid coronary atherosclerosis imaging.

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Optimization of reconstruction and quantification of motion-corrected coronary PET-CT

Abstract: The number of iterations and extent of post-filtering has marked effects on coronary F-NaF PET quantification. Cardiac motion-correction improves discrimination between culprit and reference lesions.

Cited by 44 publications

References 17 publications

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Atherosclerosis imaging with 18F-sodium fluoride PET: state-of-the-art review

Optimizing arterial 18F-sodium fluoride positron emission tomography analysis

The clinical utility of hybrid imaging for the identification of vulnerable plaque and vulnerable patients

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