[18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis

Tanaka, Shigeru; Ikeda, Kei; Uzawa, Katsuhiro; Iwamoto, Taro; Sanayama, Yoshie; Okubo, A.; Nakagomi, Daiki; Takahashi, Kentaro; Yokota, Masaya; Suto, Akira; Suzuki, Kotaro; Nakajima, Hiroshi

doi:10.1093/rheumatology/ket112

Cited by 72 publications

(54 citation statements)

References 23 publications

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“…Regarding the FDG uptake and myositis in DM, Tanaka et al 9 reported that mean SUV in proximal muscles of myositis patients was correlated with serum CK levels, and that local SUV correlated with the histological grade for inflammatory cell infiltration in muscle biopsies. Owada et al 7 reported that the sensitivity of FDG-PET to detect myositis was lower than that of electromyography, MRI and muscle biopsy.…”

Section: Discussionmentioning

confidence: 99%

“…5 Therefore, to evaluate the presence and activity of malignancy by high-resolution computed tomography (HRCT) and blood tests, such as Krebs von den Lungen-6 (KL-6) and tumor markers is important in considering treatment and prognosis in DM patients. [7][8][9][10] However, several studies demonstrated that elevated FDG uptake in muscle did not correlate with MRI findings and serum levels of skeletal muscle-derived enzymes. FDG uptake is correlated to glucose metabolism in the human body, and accumulates in inflammatory lesions where glucose-consuming inflammatory cells infiltrate.…”

Section: Introductionmentioning

confidence: 99%

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Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Motegi

Fujiwara

Sekiguchi

et al. 2019

The Journal of Dermatology

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18F‐Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) is usually used to screen malignancy in patients with dermatomyositis (DM). Additionally, it is well known that FDG‐PET/CT provides valuable information for evaluating the activity of several inflammatory diseases, such as sarcoidosis, atherosclerosis, inflammatory bowel disease and rheumatoid arthritis. Therefore, the objective of this study was to evaluate the clinical usefulness of FDG‐PET/CT for the detection of inflammatory lesions and disease activity of both myopathy and interstitial lung disease (ILD) in DM patients. We measured the maximum standardized uptake value (SUVmax) in the muscles and lungs in 22 DM patients, and compared with magnetic resonance imaging (MRI) and high‐resolution computed tomography (HRCT) findings in the same muscle and lung regions as well as with clinical findings. We found that the location of increased FDG uptake was nearly consistent with the region of ILD and myositis detected by HRCT or MRI, respectively. There was a significant positive correlation between lung HRCT score and SUVmax in each lung. Serum Krebs von den Lungen‐6 levels also revealed significant positive correlation with total SUVmax of right and left lungs. Regarding FDG‐PET/CT and myopathy, total SUVmax in the muscles was significantly correlated with serum cytokeratin levels. Our results suggest that FDG uptake (SUVmax) might be useful for not only the detection of malignant tumors, but also the evaluation of the location and activity of ILD and myositis in DM patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Motegi

Fujiwara

Sekiguchi

et al. 2019

The Journal of Dermatology

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“…PET/CT was examined in Sannoh Hospital Medical Center. Patients were subjected to PET/CT in the Diagnostic PET Imaging Center, Department of Radiology, Sannoh Medical Center (Chiba, Japan) (19). Patients fasted overnight or for at least 6 h before injection of 4.0 mega Bq/kg of 18 F-FDG.…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Tomizawa

Shinozaki

Uchida

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively. In total, 10 men (age, 73.6±9.6 years) and 8 women (age, 68.9±7.1 years) were enrolled into the current study. Of the enrolled patients, 2 were diagnosed with hepatocellular carcinoma, 1 with cholangiocellular carcinoma, 1 with liver metastasis, 2 with pancreatic ductal adenocarcinoma, 1 with renal cell carcinoma and 1 with malignant lymphoma. Benign lesions were also analyzed, including adenomyomatosis of the gallbladder (5 patients), intraductal papillary mucinous neoplasm (4 patients) and right adrenal adenoma (1 case). All the patients with cancer showed positive results on DWIBS/T2 images. However, only 7 out of 8 patients were positive with PET/CT. One patient with right renal cellular carcinoma was positive with DWIBS/T2, but negative with PET/CT. All the patients with benign lesions were negative with DWIBS/T2 and PET/CT. In conclusion, DWIBS/T2 was more sensitive in diagnosing cancer of organs in the abdominal cavity compared with PET/CT. Furthermore, negative results with DWIBS/T2 and PET/CT were useful for the diagnosis of benign lesions, such as adenomyomatosis of the gallbladder and intraductal papillary mucinous neoplasm.

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“…18 F] FDG-PET/CT makes it possible to conduct systemic screening for inflammation and it is useful to determine the optimal site to perform tissue biopsy (2). As a result, […”

Section: Picturementioning

confidence: 99%

Eosinophilic Fasciitis Illustrated by [<sup>18</sup>F] FDG-PET/CT

et al. 2016

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A 69-year-old woman presented with a 2-month history of fatigue and progressive stiffness in her forearms without any skin manifestations. Laboratory tests showed an elevated erythrocyte sedimentation rate and hypereosinophilia. [18 F] FDG-PET/CT revealed a diffuse and symmetrical FDG uptake in the fasciae of the upper limbs and girdles (Picture A-C). A biopsy specimen from the right deltoid muscle, in which the FDG uptake was the strongest, showed marked eosinophilic infiltration in the fascia, but not in the muscle (Picture D). She was therefore diagnosed with eosinophilic fasciitis and treated successfully with corticosteroids.

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[18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis

Cited by 72 publications

References 23 publications

Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Eosinophilic Fasciitis Illustrated by [<sup>18</sup>F] FDG-PET/CT

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[18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis

Cited by 72 publications

References 23 publications

Clinical value of 18F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Clinical value of 18F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Eosinophilic Fasciitis Illustrated by [<sup>18</sup>F] FDG-PET/CT

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Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis

Clinical value of ¹⁸F‐fluorodeoxyglucose positron emission tomography/computed tomography for interstitial lung disease and myositis in patients with dermatomyositis