Comparison of DWIBS/T2 image fusion and PET/CT for the diagnosis of cancer in the abdominal cavity

Abstract

Abstract. Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with 18 F-fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively. In total, 10 men (age, 73.6±9.6 years) and 8 women (age, 68.9±7.1 years) were enrolled into the current study. Of the enrolled patients, 2 were diagnosed with hepatocellular carcinoma, 1 with cholangiocellular carcinoma, 1 with liver metastasis, 2 with pancreatic ductal adenocarcinoma, 1 with renal cell carcinoma and 1 with malignant lymphoma. Benign lesions were also analyzed, including adenomyomatosis of the gallbladder (5 patients), intraductal papillary mucinous neoplasm (4 patients) and right adrenal adenoma (1 case). All the patients with cancer showed positive results on DWIBS/T2 images. However, only 7 out of 8 patients were positive with PET/CT. One patient with right renal cellular carcinoma was positive with DWIBS/T2, but negative with PET/CT. All the patients with benign lesions were negative with DWIBS/T2 and PET/CT. In conclusion, DWIBS/T2 was more sensitive in diagnosing cancer of organs in the abdominal cavity compared with PET/CT. Furthermore, negative results with DWIBS/T2 and PET/CT were useful for the diagnosis of benign lesions, such as adenomyomatosis of the gallbladder and intraductal papillary mucinous neoplasm.

Representation of DNA environment: Spiral staircase distribution function

“…Using the red–green–blue (RGB) primary or cyan–magenta–yellow–black (CMYK) secondary colors of light one can combine two or three SSDFs in one figure. This is similar to “image fusion” in tomography . Such kind of analysis is presented and discussed below in subsection “Interactions of ions with purines and pyrimidines.”…”

Clinical Value of Diffusion-Weighted Whole-Body Imaging with Background Body Signal Suppression (DWIBS) for Staging of Patients with Suspected Head and Neck Cancer

“…In order to deal with motion artifacts, Takahara et al developed diffusion-weighted whole-body imaging with background body signal suppression (DWIBS). This sequence allows for the acquisition of diffusion-weighted imaging under free-breathing [ 2 , 8 , 9 , 10 , 11 , 12 ].…”

Two cases of oligometastatic castration‐resistant prostate cancer detected by diffusion‐weighted whole‐body imaging with background body signal suppression

“…The advantage of DWIBS is the strong contrast of positive signals against normal tissues; thus, DWIBS is useful for identifying primary and metastatic lesions. DWIBS can also detect osteolytic changes, lymph node metastasis, and visceral metastasis in addition to osteoblastic changes . We encountered cases of CRPC wherein we could not detect osteolytic bone metastasis in the sacrum with CT (Fig.…”

“…DWIBS can also detect osteolytic changes, lymph node metastasis, and visceral metastasis in addition to osteoblastic changes. [8][9][10] We encountered cases of CRPC wherein we could not detect osteolytic bone metastasis in the sacrum with CT ( Fig. 1a), without the results of DWIBS ( Fig.…”