18F-FDG cerebellum/liver index as a prognostic factor for progression-free survival in diffuse large B-cell lymphoma

Morland, David; Zizi, G.; Guilhot, François; Gauchy, Anne-Cécile; Durot, Carole; Hoeffel, Christine; Delmer, Alain; Papathanassiou, Dimitri; Durot, Éric

doi:10.1007/s12149-021-01609-4

Cited by 4 publications

(18 citation statements)

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“…UF remained significant at bivariate analysis when adding IPS score with an HR of 2.3 (derived EFS of 84.9 vs. 63.7%). The metabolic theft hypothesis for which FDG-avid tumor masses would deprive healthy organs of 18 F-FDG was investigated in two papers on diffuse large-cell B-cell and follicular lymphomas (10,12). Cerebellar and hepatic 18 F-FDG uptake values were reported to be inversely correlated to TMTV.…”

Section: Discussion Healthy Organs 18 F-fdg Uptake Values and Derived...mentioning

confidence: 99%

“…Harmonization allowed us to study cerebellar and hepatic uptake independently, without having to use a ratio for normalization purposes. The use of a ratio disturbed the correlation between healthy organ and TMTV in the article by Morland et al ( 10 ), but was still necessary to ensure good inter-machine agreement. The ComBat harmonization allowed us to overcome this problem.…”

Section: Discussionmentioning

confidence: 99%

“…The drawbacks of TMTV calculation (results depending on the segmentation method (9), time required for delineation (10), difficulty in evaluating bone involvement) led to ponder other prognostic markers, such as healthy organ 18 F-FDG uptake. In 2010, Hanaoka et al (11) reported an inverse correlation between cerebellar uptake and total lesion glycolysis (TLG) in a population with aggressive lymphoma.…”

Section: Introductionmentioning

confidence: 99%

“…Because TLG is correlated with TMTV, Godard et al (12) speculated that cerebellar metabolism might have a prognostic value and suggested to normalize cerebellar 18 F-FDG uptake to hepatic 18 F-FDG uptake to account for differences between PET/CT systems. This index has been shown to be a prognostic parameter for PFS prediction in diffuse large-B-cell lymphoma (10) and follicular lymphoma (12). Normalization to liver was not optimal: liver 18 F-FDG uptake was also negatively correlated with TMTV as was cerebellar 18 F-FDG uptake (r = −0.34 and r = −0.42, respectively) (10).…”

Section: Introductionmentioning

confidence: 99%

“…This index has been shown to be a prognostic parameter for PFS prediction in diffuse large-B-cell lymphoma (10) and follicular lymphoma (12). Normalization to liver was not optimal: liver 18 F-FDG uptake was also negatively correlated with TMTV as was cerebellar 18 F-FDG uptake (r = −0.34 and r = −0.42, respectively) (10). These two healthy organs could thus prove useful in predicting prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Healthy Organs Uptake on Baseline 18F-FDG PET/CT as an Alternative to Total Metabolic Tumor Volume to Predict Event-Free Survival in Classical Hodgkin's Lymphoma

et al. 2022

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PurposeHealthy organs uptake, including cerebellar and liver SUVs have been reported to be inversely correlated to total metabolic tumor volume (TMTV), a controversial predictor of event-free survival (EFS) in classical Hodgkin's Lymphoma (cHL). The objective of this study was to estimate TMTV by using healthy organs SUV measurements and assess the performance of this new index (UF, Uptake Formula) to predict EFS in cHL.MethodsPatients with cHL were retrospectively included. SUV values and TMTV derived from baseline 18F-FDG PET/CT were harmonized using ComBat algorithm across PET/CT systems. UF was estimated using ANOVA analysis. Optimal thresholds of TMTV and UF were calculated and tested using Cox models.Results163 patients were included. Optimal UF model of TMTV included age, lymphoma maximum SUVmax, hepatic SUVmean and cerebellar SUVmax (R2 14.0% - p < 0.001). UF > 236.8 was a significant predictor of EFS (HR: 2.458 [1.201–5.030], p = 0.01) and was not significantly different from TMTV > 271.0 (HR: 2.761 [1.183–5.140], p = 0.001). UF > 236.8 remained significant in a bivariate model including IPS score (p = 0.02) and determined two populations with different EFS (63.7 vs. 84.9%, p = 0.01).ConclusionThe Uptake Formula, a new index including healthy organ SUV values, shows similar performance to TMTV in predicting EFS in Hodgkin's Lymphoma. Validation cohorts will be needed to confirm this new prognostic parameter.

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Section: Discussion Healthy Organs 18 F-fdg Uptake Values and Derived...mentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Healthy Organs Uptake on Baseline 18F-FDG PET/CT as an Alternative to Total Metabolic Tumor Volume to Predict Event-Free Survival in Classical Hodgkin's Lymphoma

et al. 2022

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PET/CT in Non-Hodgkin Lymphoma: An Update

Zanoni

Bezzi

Nanni

et al. 2023

Seminars in Nuclear Medicine

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The remodeling of metabolic brain pattern in patients with extracranial diffuse large B-cell lymphoma

Liu,

Tang,

Zhu

et al. 2023

EJNMMI Res

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Background Owing to the advances in diagnosis and therapy, survival or remission rates for lymphoma have improved prominently. Apart from the lymphoma- and chemotherapy-related somatic symptom burden, increasing attention has been drawn to the health-related quality of life. The application of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT) has been routinely recommended for the staging and response assessment of FDG-avid lymphoma. However, up till now, only a few researches have investigated the brain metabolic impairments in patients with pre-treatment lymphoma. The determination of the lymphoma-related metabolic brain pattern would facilitate exploring the tailored therapeutic regimen to alleviate not only the physiological, but also the psychological symptoms. In this retrospective study, we aimed to establish the diffuse large B-cell lymphoma-related pattern (DLBCLRP) of metabolic brain network and investigate the correlations between DLBCLRP and several indexes of the staging and response assessment. Results The established DLBCLRP was characterized by the increased metabolic activity in bilateral cerebellum, brainstem, thalamus, striatum, hippocampus, amygdala, parahippocampal gyrus and right middle temporal gyrus and by the decreased metabolic activity in bilateral occipital lobe, parietal lobe, anterior cingulate gyrus, midcingulate cortex and medial frontal gyrus. Significant difference in the baseline expression of DLBCLRP was found among complete metabolic response (CMR), partial metabolic response (PMR) and progressive metabolic disease (PMD) groups (P < 0.01). DLBCLRP expressions were also significantly or tended to be positively correlated with international prognostic index (IPI) (rs = 0.306, P < 0.05), lg(total metabolic tumor volume, TMTV) (r = 0.298, P < 0.05) and lg(total lesion glycolysis, TLG) (r = 0.233, P = 0.064). Though no significant correlation of DLBCLRP expression was found with Ann Arbor staging or tumor SUVmax (P > 0.05), the post-treatment declines of DLBCLRP expression were significantly positively correlated with Ann Arbor staging (rs = 0.284, P < 0.05) and IPI (rs = 0.297, P < 0.05). Conclusions The proposed DLBCLRP would lay the foundation for further investigating the cerebral dysfunction related to DLBCL itself and/or treatments. Besides, the expression of DLBCLRP was associated with the tumor burden of lymphoma, implying a potential biomarker for prognosis.

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18F-FDG cerebellum/liver index as a prognostic factor for progression-free survival in diffuse large B-cell lymphoma

Cited by 4 publications

References 32 publications

Healthy Organs Uptake on Baseline 18F-FDG PET/CT as an Alternative to Total Metabolic Tumor Volume to Predict Event-Free Survival in Classical Hodgkin's Lymphoma

Healthy Organs Uptake on Baseline 18F-FDG PET/CT as an Alternative to Total Metabolic Tumor Volume to Predict Event-Free Survival in Classical Hodgkin's Lymphoma

PET/CT in Non-Hodgkin Lymphoma: An Update

The remodeling of metabolic brain pattern in patients with extracranial diffuse large B-cell lymphoma

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