18F-FDG and11C-methionine PET for evaluation of treatment response of lung cancer after stereotactic radiotherapy

Abstract

This study was performed to investigate the feasibility of FDG- and L-[methyl-11C]methionine (Met)-PET for the follow up of lung cancer after stereotactic radiotherapy (SRT). Nine patients (pt) with solitary lung cancer underwent SRT. Met- and FDG-PET studies were performed one week before SRT and from one week to 8 months after SRT. Responses to SRT were complete in 2 pt and partial in 7 pt. Met- and FDG-PET scan showed high tracer uptake in all tumors before SRT. After SRT, standardized uptake values (SUV) of FDG and Met changed concordantly. Both decreased with time in 5 pt but did not decrease steadily in 4 pt, where 2 pt showed an increase at 1 to 2 weeks after SRT and 2 pt showed an increase at more than 3 months after SRT. The former appears to reflect the acute reaction to SRT and the latter radiation-induced pneumonitis. Although the addition of Met-PET did not provide additional information over FDG-PET, FDG- and Met-PET could be used to evaluate the treatment effect of SRT.

FDG-PET and stereotactic body radiotherapy (SBRT) for stage I non-small-cell lung cancer

“…There is extremely limited data on PET following SBRT. Ishimori analysed nine patients retrospectively who had received SBRT for early NSCLC and were followed with both FDG-PET and 11C-methionine PET [32]. Five patients showed decreasing SUV with time.…”

Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy

“…Despite investigations on the prognostic utility of maximum standardized uptake value (SUV max ) from PET-CT in patient with early stage NSCLC treated with SABR, the role of metabolic imaging in this context remains unclear [11][12][13][14][15][16].…”

Paraneoplastic Neurological Syndromes and the Role of PET Imaging

“…The results of both tracers were similar, but uptake of [ 18 F]FMT correlated better with the expression of LAT1 that showed a significant association with cellular proliferation [58]. Comparison of 18 F-FDG and 11 C-methionine (Met) PET, employed for evaluation of treatment response of lung cancer after stereotactic radiotherapy, showed that Met PET did not provide additional information on 18 F-FDG PET [59]. …”