Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy

Abelson, J.A.; Murphy, James D.; Trakul, Nicholas; Bazan, Jose G.; Maxim, Peter G.; Graves, Edward E.; Quon, Andrew; Le, Quynh‐Thu; Diehn, Maximilian; Loo, Billy W.

doi:10.1016/j.lungcan.2012.08.016

Cited by 45 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Most probable, however, is that this lack of correlation between SUV max and outcomes after SBRT is a function of the relatively small number of patients in most SBRT series. In keeping with the hypothesis that low sample size is the driving factor for these inconsistent results, 3 of the 4 studies demonstrating a correlation between SUV max and OS in the setting of SBRT have been among the largest series reported [27-29]. …”

Section: Discussionmentioning

confidence: 99%

FDG-PET maximum standardized uptake value is prognostic for recurrence and survival after stereotactic body radiotherapy for non-small cell lung cancer

Wu¹,

Zhang²,

Foster³

et al. 2015

Lung Cancer

View full text Add to dashboard Cite

Objectives Glucose metabolic activity measured by [18F]-fluoro-2-deoxy-glucose positron emission tomography (FDG-PET) has shown prognostic value in multiple malignancies, but results are often confounded by the inclusion of patients with various disease stages and undergoing various therapies. This study was designed to evaluate the prognostic value of tumor FDG uptake quantified by maximum standardized uptake value (SUVmax) in a large group of early-stage non-small cell lung cancer (NSCLC) patients treated with stereotactic body radiotherapy (SBRT) using consistent treatment techniques. Materials and Methods 219 lesions in 211 patients treated with definitive SBRT for stage I NSCLC were analyzed after a median follow-up of 25.2 months. Cox regression was used to determine associations between SUVmax and overall survival (OS), disease-specific survival (DSS), and freedom from local recurrence (FFLR) or distant metastasis (FFDM). Results SUVmax >3.0 was associated with worse OS (p<0.001), FFLR (p=0.003) and FFDM (p=0.003). On multivariate analysis, OS was associated with SUVmax (HR 1.89, p=0.03), gross tumor volume (GTV) (HR 1.94, p=0.005) and Karnofsky performance status (KPS) (HR 0.51, p=0.008). DSS was associated only with SUVmax (HR 2.58, p=0.04). Both LR (HR 11.47, p=0.02) and DM (HR 3.75, p=0.006) were also associated with higher SUVmax. Conclusion In a large patient population, SUVmax >3.0 was associated with worse survival and a greater propensity for local recurrence and distant metastasis after SBRT for NSCLC.

show abstract

Section: Discussionmentioning

confidence: 99%

FDG-PET maximum standardized uptake value is prognostic for recurrence and survival after stereotactic body radiotherapy for non-small cell lung cancer

Wu¹,

Zhang²,

Foster³

et al. 2015

Lung Cancer

View full text Add to dashboard Cite

show abstract

“…Third, we evaluated only the SUVmax as a quantitative result of the FDG PET. Recently, volumetric parameters, including whole-body metabolic tumour volume or total lesion glycolysis, have been introduced for the prediction of outcomes and therapy responses in patients with solid tumours [32][33][34]. However, these parameters have not been validated sufficiently [35].…”

Section: Discussionmentioning

confidence: 99%

Large cell neuroendocrine carcinoma of the lung: CT and FDG PET findings

Lee

et al. 2015

European Journal of Radiology

View full text Add to dashboard Cite

“…However, there is insufficient evidence to draw the same conclusion for higher stage NSCLC patients [20–22]. In our cohort of patients, maximum SUV presented no statistical significant predictor of survival.…”

Section: Discussionmentioning

confidence: 45%

Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer

et al. 2013

View full text Add to dashboard Cite

Background Maximum, mean and peak SUV of primary tumor at baseline FDG-PET scans, have often been found predictive for overall survival in non-small cell lung cancer (NSCLC) patients. In this study we further investigated the prognostic power of advanced metabolic metrics derived from Intensity-Volume Histograms (IVH) extracted from PET imaging. Methods A cohort of 220 NSCLC patients (mean age, 66.6 years; 149 men, 71 women), stages I-IIIB, treated with radiotherapy with curative intent were included (NCT00522639). Each patient underwent standardized pre-treatment CT-PET imaging. Primary GTV was delineated by an experienced radiation oncologist on CT-PET images. Common PET descriptors such as maximum, mean and peak SUV, and metabolic tumor volume (MTV) were quantified. Advanced descriptors of metabolic activity were quantified by IVH. These comprised 5 groups of features: Absolute and Relative Volume above Relative Intensity threshold (AVRI and RVRI), Absolute and Relative Volume above Absolute Intensity threshold (AVAI and RVAI), and Absolute Intensity above Relative Volume threshold (AIRV). MTV was derived from the IVH curves for volumes with SUV above 2.5, 3 and 4, and of 40% and 50% maximum SUV. Univariable analysis using Cox Proportional Hazard Regression was performed for overall survival assessment. Results Relative volume above higher SUV (80 %) was an independent predictor of OS (p = 0.05). None of the possible surrogates for MTV based on volumes above SUV of 3, 40% and 50% of maximum SUV showed significant associations with OS (p (AVAI3) = 0.10, p (AVAI4) = 0.22, p (AVRI40%) = 0.15, p (AVRI50%) = 0.17). Maximum and peak SUV (r = 0.99) revealed no prognostic value for OS (p (maximum SUV) = 0.20, p (peak SUV) = 0.22). Conclusions New methods using more advanced imaging features extracted from PET were analyzed. Best prognostic value for OS of NSCLC patients was found for relative portions of the tumor above higher uptakes (80% SUV).

show abstract

Metabolic imaging metrics correlate with survival in early stage lung cancer treated with stereotactic ablative radiotherapy

Cited by 45 publications

References 33 publications

FDG-PET maximum standardized uptake value is prognostic for recurrence and survival after stereotactic body radiotherapy for non-small cell lung cancer

FDG-PET maximum standardized uptake value is prognostic for recurrence and survival after stereotactic body radiotherapy for non-small cell lung cancer

Large cell neuroendocrine carcinoma of the lung: CT and FDG PET findings

Prognostic value of metabolic metrics extracted from baseline positron emission tomography images in non-small cell lung cancer

Contact Info

Product

Resources

About