17β-Estradiol inhibits estrogen binding protein-mediated hypha formation in Candida albicans

Kurakado, Sanae; Kurogane, Rie; Sugita, Takashi

doi:10.1016/j.micpath.2017.05.038

Cited by 10 publications

(8 citation statements)

References 31 publications

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“…Considered typical gut and mouth flora, C. albicans can act as an opportunistic pathogen and overgrow to the point of infection. It is the main cause of vaginal candidiasis but can also infect the mouth, throat and bloodstream [ 2 , 83 , 84 ]. The reversal of the sex bias in C. albicans , compared to C. neoformans and P. brasilienis may be explained in a few ways.…”

Section: Other Fungi Exhibiting Sexual Dimorphism In Infectionmentioning

confidence: 99%

An Overview of Sex Bias in C. neoformans Infections

Guess

Rosen

McClelland

2018

JoF

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Cryptococcosis, a fungal disease arising from the etiologic agent Cryptococcus neoformans, sickens a quarter of a million people annually, resulting in over 180,000 deaths. Interestingly, males are affected by cryptococcosis more frequently than females, a phenomenon observed for more than a half century. This disparity is seen in both HIV− (~3M:1F) and HIV+ (~8M:2F) populations of cryptococcal patients. In humans, male sex is considered a pre-disposing risk factor for cryptococcosis and males suffering from the disease have more severe symptoms and poorer outcomes. There are numerous observational, clinical and epidemiological studies documenting the male disadvantage in C. neoformans but with no further explanation of cause or mechanism. Despite being commonly acknowledged, little primary research has been conducted elucidating the reasons for these differences. The research that has been conducted, however, suggests sex hormones are a likely cause. Given that the sex difference is both prevalent and accepted by many researchers in the field, it is surprising that more is not known. This review highlights the data regarding differences in sexual dimorphism in C. neoformans infections and suggests future directions to close the research gap in this area.

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Section: Other Fungi Exhibiting Sexual Dimorphism In Infectionmentioning

confidence: 99%

An Overview of Sex Bias in C. neoformans Infections

Guess

Rosen

McClelland

2018

JoF

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“…In this study, although we did not know whether genetic mutations are present, we found that FCY2 (B9J08_002435) was upregulated in the resistant C. auris strain, a finding that is consistent with the drug sensitivity results obtained for 5FC (MIC≤0.06 μg/ml). EBP1 was also upregulated in the resistant C. auris strain, and previous studies identified that it plays an essential role in the yeast-to-hypha transition ( Kurakado et al, 2017 ). Furthermore, pertaining to genes involved in CO 2 signaling in fungi, NCE103 and UME6 were upregulated in the resistant C. auris strain.…”

Section: Discussionmentioning

confidence: 82%

A Comparative Transcriptome Between Anti-drug Sensitive and Resistant Candida auris in China

Zhou

Lin

et al. 2021

Front. Microbiol.

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Candida auris emerged as a pathogenic species of fungus that causes severe and invasive outbreaks worldwide. The fungus exhibits high intrinsic resistance rates to various first-line antifungals, and the underlying molecular mechanism responsible for its multidrug resistance is still unclear. In this study, a transcriptomic analysis was performed between two C. auris isolates that exhibited different anti-drug patterns by RNA-sequencing, namely, CX1 (anti-drug sensitive) and CX2 (resistant). Transcriptomic analysis results revealed 541 upregulated and 453 downregulated genes in the resistant C. auris strain compared with the susceptible strain. In addition, our findings highlight the presence of potential differentially expressed genes (DEGs), which may play a role in drug resistance, including genes involved in ergosterol and efflux pump biosynthesis such as SNQ2, CDR4, ARB1, MDR1, MRR1, and ERG genes. We also found that Hsp related genes were upregulated for expression in the anti-drug-resistant strain. Biofilm formation and growth conditions were also compared between the two isolates. Our study provides novel clues for future studies in terms of understanding multidrug resistance mechanisms of C. auris strains.

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“…Cinsiyet hormonlarından olan progesteron ve östradiolün ise bazı bakterilerde (Prevotella intermedius ve Bacterioides meloninogenicus gibi) konsantrasyona bağlı olarak K vitamini gibi görev yaptığı ve bakterilerin üremelerini etkilediği gösterilmiştir (26,34) . Ayrıca çeşitli mayalar (C. albicans ve P. brasiliensis) ile yapılan çalışmalarda steroid bağlayan proteinlerin bu mikroorganizmalarda bulunduğunun gösterilmesi, cinsiyet hormonlarının fizyolojik süreçlerde değişimlere aracılık etmesi şeklinde yorumlanmaktadır (19,25) .…”

Section: Grafik 6 Farklı Norepinefrin Konsantrasyonlarınınunclassified

“…Mikrobiyal endokrinoloji araştırmaları, genel olarak, bakterilerle stres hormonları olarak bilinen katekolaminler [epinefrin (E), norepinefrin (NE) ve dopamin (D)] arasındaki ilişkiye odaklanmışsa da kimi araştırmacılar diğer bazı hormonları da [östradiol (Ö), insülin (İ), progesteron (P), testosteron (T) gibi] çalışma konusu edinmişlerdir (20)(21)(22)(23)(24)(25)(26)(27) .…”

Section: Introductionunclassified

Effects of Insulin, Norepinephrine and Estradiol on Growth of Different Microorganisms

Gümüş¹,

Yüksek²,

Uz³

et al. 2018

TMCD

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ÖZ Amaç: Konağa yerleşen mikroorganizmaların üremeleri, virulans ve antibiyotiklere duyarlılık da dâhil olmak üzere tüm özellikleri konak koşulları tarafından kontrol edilir. Çalışmamızda, bir konak faktörü olarak östradiol, insülin ve norepinefrinin farklı mikroorganizmaların (Üropatojen Escherichia coli C7, Candida albicans SC5314, Enterococcus faecalis ATCC 29212, Metisiline dirençli Staphylococcus auerus (MRSA) ATCC 43300 ve Pseudomonas aeruginosa ATCC 27853) üremesi üzerine etkilerinin in vitro olarak belirlenmesi amaçlanmıştır. Gereç ve Yöntem: Bu amaçla, mikroorganizmalar hormonların farklı konsantrasyonlarını içeren ve içermeyen (kontrol) besiyerlerinde (Triptik soy buyyon ve Sabouraud dekstroz buyyon) üretilmişlerdir. Mikroorganizmaların üremeleri spektrofotometre ile 4., 6. ve 24. saatlerde ölçülerek belirlenmiştir. Üremelerin istatistiksel değerlendirilmesinde çift yönlü ANOVA Bonferroni post-test kullanılmıştır. Bulgular: Çalışmamızda denenen tüm hormon konsantrasyonlarının 6 saat inkübasyon sonunda E. faecalis üremesini kontrol besiyerine göre istatistiksel olarak anlamlı düzeyde baskıladığı, C. albicans üremesinin hormon ilave edilen besiyerlerinde 24 saat inkübasyonda anlamlı şekilde değiştiği (200 µU/ mL insülin ve 20 pg/mL östradiolda azalma; 150 pg/mL ve 400 pg/mL östradiol ile 1.700 pg/mL, 7.500 pg/mL ve 40.000 pg/mL norepinefrinde artma) belirlenmiştir. Buna karşın denenen hormonların MRSA, P. aeruginosa ve UPEC suşlarının üremesi üzerine herhangi bir etkisi olmadığı görülmüştür (p>0.05). Sonuç: Memeli hormonlarının mikroorganizmaların davranışları üzerinde de etkilerinin gösterilmesi ile konakta çevresel bir unsur olarak enfeksiyon patogenezini belirledikleri vurgulanmaktadır. Çalışmamızdan elde edilen sonuçlar ile farklı konsantrasyonlardaki hormonların mikroorganizmaların üremelerinde çeşitli etkilere sahip olduğu desteklenmektedir. Bu ve benzeri çalışmalar, hormonların insanda enfeksiyon sürecini doğrudan belirlediğini göstermektedir. Anahtar kelimeler: İnter-kingdom haberleşme, insülin, östradiol, norepinefrin, üreme ABSTRACT Effects of Insulin, Norepinephrine and Estradiol on Growth of Different MicroorganismsObjective: All characteristics of microorganisms colonized in host including their growth, virulence and antibiotic susceptibilities are controlled by host conditions. In our study, it has been aimed to determine the effects of estradiol, insulin, norepinephrine as host factors on the growth of various microorganisms (uropathogenic Escherichia coli C7, Candida albicans SC5314, Enterococcus faecalis ATCC 29212, Methicillin resistant Staphylococcus auerus (MRSA) ATCC 43300 and Pseudomonas aeruginosa ATCC 27853) in vitro setting. Material and Methods:For this purpose, microorganisms were grown in different culture media (Tryptic Soy Broth and Sabouraud Dextrose Broth) supplemented with/without various concentrations of hormones. Growths of microorganisms were measured at 4 th , 6 th and 24 th hours using a spectrophotometer. Statistical analysis of growths were determined by using tw...

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17β-Estradiol inhibits estrogen binding protein-mediated hypha formation in Candida albicans

Cited by 10 publications

References 31 publications

An Overview of Sex Bias in C. neoformans Infections

An Overview of Sex Bias in C. neoformans Infections

A Comparative Transcriptome Between Anti-drug Sensitive and Resistant Candida auris in China

Effects of Insulin, Norepinephrine and Estradiol on Growth of Different Microorganisms

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