17Z‐Tetracosenyl 1‐glycerol ether from the spongesCinachyra alloclada andUlosa ruetzleri

Cardellina, John H.; Graden, Clinton J.; Greer, Bradley J.; Kern, John R.

doi:10.1007/bf02536103

Cited by 23 publications

(24 citation statements)

References 19 publications

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“…Cardellina II et al [11]. isolated an indolic metabolite, and the first compound identified for this sponge was an unusual lipid, 17 Z ‐Tetracosenyl 1‐Glycerol Ether [10]. To the best of our knowledge, our study is the first report on the chemical analysis of S. ruetzleri collected in the Brazilian coastline; on the other hand, the presence of lipid compounds found in our study is in agreement with the initial report for this sponge species.…”

Section: Discussionsupporting

confidence: 92%

“…At this moment, only four metabolites were isolated from S. ruetzleri collected in Harrington Sound, Bermuda [10–12]. The first compound isolated was an unusual lipid, 17 Z ‐tetracosenyl 1‐glycerol ether [10].…”

Section: Introductionmentioning

confidence: 99%

“…[9] At this moment, only four metabolites were isolated from S. ruetzleri collected in Harrington Sound, Bermuda. [10][11][12] The first compound isolated was an unusual lipid, 17Ztetracosenyl 1-glycerol ether. [10] More recently, organic extracts of S. ruetzleri have shown cytotoxic activity against human breast cancer cells [13] and antifungal effects against Candida albicans.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12] The first compound isolated was an unusual lipid, 17Ztetracosenyl 1-glycerol ether. [10] More recently, organic extracts of S. ruetzleri have shown cytotoxic activity against human breast cancer cells [13] and antifungal effects against Candida albicans. [14] These data open up very interesting perspectives for the study of this sponge.…”

Section: Introductionmentioning

confidence: 99%

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Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge S copalina ruetzleri

Biegelmeyer

Schröder

Rambo

et al. 2015

Journal of Pharmacy and Pharmacology

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge S copalina ruetzleri

Biegelmeyer

Schröder

Rambo

et al. 2015

Journal of Pharmacy and Pharmacology

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“…O 2,3-propanodiol, 1-heptadeciloxi foi encontrado anteriormente na esponja Haliclona sp 16 . O álcool batílico também foi isolado da esponja Ulosa ruetzleri 33 ; da esponja Tedania ignis 34 , da esponja Haliclona sp. 16 , da esponja Suberites vestigium 35 e da esponja Mycale mytilorum 36 .…”

Section: Resultsunclassified

Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada na costa cearense

Takeara

Lopes

et al. 2007

Quím. Nova

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Recebido em 7/7/06; aceito em 9/11/06; publicado na web em 14/5/07 CHEMICAL CONSTITUENTS FROM THE ASCIDIAN Didemnum psammatodes (SLUITER, 1895) COLLECTED ON THE SHORES OF CEARA STATE. Chemical investigation of the methanolic extract of the ascidian Didemnum psammatodes has led to the identification of the nucleosides 2'-deoxyuridine (1), thymidine (2), 2'-deoxyinosine (3) and 2'-deoxyguanosine (4), the steroids cholestanol, cholestanone and stigmasterol in mixture and batyl alcohol plus two analogs, 1-heptadecyloxy-2,3-propanediol and 1-nonadecyloxy-2,3-propanediol in mixture. Their structures were proposed by NMR, MS and comparison with literature data and GC-MS analysis.Keywords: chemical contituents; Didemnum psammatodes; tunicate. INTRODUÇÃOO ambiente marinho é considerado uma rica fonte de compostos com atividades biológicas interessantes, como agentes anti-tumorais, antiinflamatórios, analgésicos, imunomodulatórios, alergênicos e antivirais 1 . As ascídias são invertebrados marinhos produtores de uma gama destes compostos, sendo a maioria deles derivados de aminoácidos 2,3 . Alguns destes derivados e alguns alcalóides de ascídias encontram-se em fase de triagem clínica como agentes anti-tumorais 1,4 .Didemnidae é a maior família de ascídias em termos de núme-ro de espécies e tem provado ser uma grande fonte de compostos naturais com diversidade química e potente propriedade biológica. Várias espécies do gênero Didemnum já foram investigadas quanto à composição química, encontrando-se predominância de alcalóides 5,6 , muitos deles com atividade citotóxica 5,[7][8][9][10] .Didemnum psammatodes apresenta ampla distribuição geográ-fica, com registros em praticamente todos os mares tropicais, sendo particularmente abundante no litoral brasileiro 11 . Pouca coisa é conhecida acerca de suas propriedades biológicas. Um estudo preliminar que descreveu a atividade citotóxica do extrato bruto das 10 espécies de ascídias mais abundantes da costa do Ceará mostrou que D. psammatodes possui atividade antimitótica sobre ovos de ouriço do mar 12 . Entretanto, não há relatos na literatura sobre a composição química desta espécie. Sendo assim, o presente trabalho descreve os principais componentes químicos da ascídia D. psammatodes. PARTE EXPERIMENTAL Instrumentação e procedimentos geraisOs espectros de RMN 1 H foram obtidos em aparelhos de RMN Brucker DRX-400, operando em 400 MHz para 1 H e 100 MHz para 13 C, respectivamente, com as amostras solubilizadas em CDCl 3 , DMSO deuterado e D 2 O. Os espectros bidimensionais de HMQC e HMBC foram obtidos em aparelho DRX-500.Os espectros de massas foram obtidos em aparelho da Micromass, modelo Micromass Quattro LC com ionização por electrospray a 45 eV.Para identificação dos esteróides foi utilizado cromatógrafo com fase gasosa acoplado a espectrômetro de massas, marca Shimadzu, modelo QP 2010, com coluna capilar HP-1, com 30 m x 0,25 mm x 0,25 μm de espessura de filme, utilizando-se as seguintes condições: temperatura do injetor: 260 ºC; gás de arraste: He; temperatura inicial do f...

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Porifera (Sponges)–1

Kornprobst

2014

Encyclopedia of Marine Natural Products

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The article contains sections titled: Overview of the Universe of Sponges Metabolites of Calcarea (Calcareous Sponges) General Characteristics of Calcarea Fatty Acids Sterols Non‐Nitrogenous Derivatives of Species of the Genus Leucetta Imidazole Alkaloids and Zinc Complexes Isolated from the Genera Leucetta , Leucosolenia , and Clathrina αω‐ Bis Long‐Chain Aminoalcohols Nitrogen‐Containing Macrolides and Cyclic Peptides Other Nitrogen‐Containing Compounds of Calcarea Metabolites of Hexactinellida Classification and Membrane Constituents of Demospongiae Classification Some Physical Observations on Demosponges Shape and Size Consistency Color and Odor Diversity of Membrane Constituents: Some Examples Phospholipids and “Demospongic Acids” Fatty Acids with 5,9 Dienic Structure Other Mono‐ and Polyunsaturated Fatty Acids Branched Fatty Acids Isoprenic Acids Cyclopropanic Acids Brominated Acids 2‐ O Substituted Acids Sulfur Derivatives of Demospongic Acids Intracellular Localization and Biological Activity of Demospongic Acids Brief Reminder About Conventional Sterols Unconventional Sterols Produced by Changes in the Tetracyclic System Unconventional Sterols Produced by Polymethylation of the Side Chain Sterols with Degraded Side Chains Sterols and Stanols with Cyclopropanic and Cyclopropenic Side Chains Secosterols Polyhydroxylated Steroids and Derivatives, Peroxysterols Sulfated Sterols Chlorinated Sterols and Sterones Nitrogen‐Containing Sterols Glycolipids Secondary Metabolites of Homoscleromorpha Fatty Acids, Polyketides and Oxylipins of Plakinastrella and Plakortis Cyclic Peroxides and Peroxylactones from Plakinastrella and Plakortis Glycosides Polyhydroxylated Sterols of Oscarella lobularis Alkaloids and Other Original Nitrogen Derivatives of Plakortis and Corticium Secondary Metabolites of Astrophorida Acetylenic Fatty Acids of Stelletta Cyclitol Derivatives Glycolipids: Caminosides and Pachymosides Triterpenes of Malabaricane and Isomalabaricane: Sesterterpenes Triterpenic Glycosides and Steroidal Glycosides Substituted Tetramic Acids and Derived Glycosides Erylusamines, Erylusine, and Erylusidine Cyclic Depsipeptides, Peptolides, and Macrolactones Nitrogen‐Containing Terpenes Bengazoles and Bengamides Atypical Nitrogenous Derivatives Phosphorus‐Containing Derivatives Aromatic and Heteroaromatic Sulfated Derivatives Isotactic Polymethoxydienes of Myriastra clavosa

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17Z‐Tetracosenyl 1‐glycerol ether from the spongesCinachyra alloclada andUlosa ruetzleri

Cited by 23 publications

References 19 publications

Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge S copalina ruetzleri

Cytotoxic effects on tumour cell lines of fatty acids from the marine sponge S copalina ruetzleri

Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada na costa cearense

Porifera (Sponges)–1

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