Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada na costa cearense

Takeara, Renata; Lopes, João Luís Callegari; Lopes, Norberto Peporine; Jimenez, Paula Christine; Costa-Lotufo, Letı́cia V.; Lotufo, Tito Monteiro da Cruz

doi:10.1590/s0100-40422007000500024

Cited by 7 publications

(5 citation statements)

References 27 publications

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“…In respect of potential future uses, coastal MHE in Ceará have been used to prospect marine natural products, with some positive results already achieved (Ávila et al, 2019a, Costa-Lotufo et al, 2006Jimenez et al, 2003;Pinto et al, 2020;Takeara et al, 2007). The discovery of new substances is of interest to many Ocean Economy sectors and the biotechnology of marine organisms has experienced rapid growth rates in recent decades (Ióca;Nicacio & Berlinck, 2018;Thompson et al, 2018).…”

Section: Economic Importancementioning

confidence: 99%

Marine Hardbottom Environments in the Beaches of Ceará State, Equatorial Coast of Brazil

Carneiro¹,

Neto

Feitosa

et al. 2021

ACMAR

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This paper is a literature review on marine hardbottom environments (MHE) that emerge in coastal regions in the Brazilian state of Ceará. This stretch of the Brazilian coast houses several rock formations, which are widely distributed in the intertidal zone. These formations have various origins and composition, ranging from crystalline rocks to biogenic structures, but most are composed by sandstones. These substrates support biodiverse ecosystems that produce valuable environmental goods and services, which have historical and socioeconomic relevance for the state. Despite their importance, they are currently threatened by various types of local and global stressors, and a consistent government effort to protect them is still lacking. There are many knowledge gaps regarding these formations and new studies are needed to support conservation actions involving these ecosystems. Keywords: reef, beachrock, sandstone, intertidal zone, benthos

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Section: Economic Importancementioning

confidence: 99%

Marine Hardbottom Environments in the Beaches of Ceará State, Equatorial Coast of Brazil

Carneiro¹,

Neto

Feitosa

et al. 2021

ACMAR

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“…The dimerized cyclic hexapeptides, antatollamides A and B (14 and 15) ( Figure 6), were purified from D. molle collected in Pohnpei [19]. Three steroids including cholestanol (16), a mixture of cholestanone and stigmasterol (17 and 18) and batyl alcohol (19) ( Figure 6) were obtained from D. psammatodes, along with the nucleosides 2 -deoxyuridine (20), thymidine (21), 2 -deoxyinosine (22) ( Figure 6), and 2 -deoxyguanosine (23) ( Figure 7) [20]. A group of indole alkaloids including 16-epi-18-acetyl herdmanine D (24), N-(6-bromo-1H-indole-3-carbonyl)-l-arginine (25), and (6-bromo-1H-indol-3-yl)oxoacetamide (26) (Figure 7), were reported from a Korean Didemnum sp.…”

Section: Secondary Metabolites With No Currently Reported Bioactivitymentioning

confidence: 99%

Secondary Metabolites of the Genus Didemnum: A Comprehensive Review of Chemical Diversity and Pharmacological Properties

et al. 2020

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Tunicates (ascidians) are common marine invertebrates that are an exceptionally important source of natural products with biomedical and pharmaceutical applications, including compounds that are used clinically in cancers. Among tunicates, the genus Didemnum is important because it includes the most species, and it belongs to the most speciose family (Didemnidae). The genus Didemnum includes the species D. molle, D. chartaceum, D. albopunctatum, and D. obscurum, as well as others, which are well known for their chemically diverse secondary metabolites. To date, investigators have reported secondary metabolites, usually including bioactivity data, for at least 69 members of the genus Didemnum, leading to isolation of 212 compounds. Many of these compounds exhibit valuable biological activities in assays targeting cancers, bacteria, fungi, viruses, protozoans, and the central nervous system. This review highlights compounds isolated from genus Didemnum through December 2019. Chemical diversity, pharmacological activities, geographical locations, and applied chemical methods are described.

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“…7,8 Moreover, new steroids 9,10 and zoanthamine alkaloids, some of them with potent biological activity, [11][12][13][14][15] were also isolated from species of the Zoanthidae family. Herein, in the continuing search to discover anticancer agents from marine sources [16][17][18][19] we have investigated the zoanthid Protopalythoa variabilis Duerden 1898, an abundant cnidarian at the coast of Ceará State, northeast of Brazil.…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic lipidic α-amino acids from the zoanthid Protopalythoa variabilis from the Northeastern coast of Brazil

Wilke¹,

Jimenez²,

Pessoa³

et al. 2009

J. Braz. Chem. Soc.

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Dois α-aminoácidos lipídicos 1a e 1b foram isolados do zoantídeo Protopalythoa variabilis através de fracionamento guiado pela atividade citotóxica. As estruturas foram determinadas por diferentes métodos espectroscópicos, tais como, RMN (ressonância magnética nuclear) 1 H e 13 C, IV (infravermelho) e espectrometria de massa de alta resolução (modo positivo). A atividade citotóxica dos extratos, das frações e 1a/1b foi avaliada in vitro através do teste do MTT contra quatro linhagens de células tumorais. Este achado tem implicações biológicas e químicas importantes para essa classe de compostos. Este é o primeiro relato de α-aminoácidos lipídicos a partir de uma fonte natural, bem como de sua atividade citotóxica.Two lipidic α-amino acids 1a and 1b were isolated from the zoanthid Protopalythoa variabilis using a bioguided fractionation for cytotoxic activity. The structures of the metabolites were determined by spectroscopic methods, including NMR (nuclear magnetic resonance) 1 H e 13 C, IR (infrared) and high resolution mass spectrometry (positive mode). The cytotoxic activity of the crude extract, as well as of the mixture of 1a and 1b were measured in vitro using the MTT assay for four human tumor cell lines. This finding has important biological and chemical implications for this type of compound. This is the first report of lipidic α-amino acids from natural sources, as well as of their cytotoxic activity.

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Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada na costa cearense

Cited by 7 publications

References 27 publications

Marine Hardbottom Environments in the Beaches of Ceará State, Equatorial Coast of Brazil

Marine Hardbottom Environments in the Beaches of Ceará State, Equatorial Coast of Brazil

Secondary Metabolites of the Genus Didemnum: A Comprehensive Review of Chemical Diversity and Pharmacological Properties

Cytotoxic lipidic α-amino acids from the zoanthid Protopalythoa variabilis from the Northeastern coast of Brazil

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