−160C/A polymorphism in the <i>E‐cadherin</i> gene promoter and risk of hereditary, familial and sporadic prostate cancer

Jonsson, Bengt‐Gunnar; Adami, Hans‐Olov; Hägglund, Maria; Bergh, Anders; Göransson, Ingela; Stattin, Pär; Wiklund, Fredrik; Grönberg, Henrik

doi:10.1002/ijc.11629

Cited by 45 publications

(30 citation statements)

References 33 publications

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“…An elevated risk for prostate carcinoma was observed in allele A carriers in a Dutch population, with a higher risk for sporadic cancers (approximately Wvefold) compared to hereditary cancer (approximately twofold) (Verhage et al 2002). This is contradictory to Swedish results, which showed a higher risk for hereditary cancers (Jonsson et al 2004). More CDH1 polymorphisms were studied in AfricanAmericans, Jamaicans and European-American men (Bonilla et al 2006).…”

Section: E-cadherinmentioning

confidence: 63%

New experimental markers for early detection of high-risk prostate cancer: role of cell–cell adhesion and cell migration

Mól

Geldof

Meijer

et al. 2007

J Cancer Res Clin Oncol

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Today's treatment and diagnosis of prostate cancer still exhibit major limitations. The search for new and additional prognostic markers is therefore still an actual Weld of interest. Potential markers involved in numerous biological processes in the tumor cell have been investigated intensively. For therapeutic interventions it is important to distinguish between harmless and aggressive disease in an early stage. Therefore the subject of this review is limited to markers associated with those functional processes, which discriminate early stage aggressive, metastatic cancer from harmless disease. Important processes in this respect are: altered cell adhesion and cellular migration. E-cadherin, N-cadherin, -catenin, integrins, focal adhesion kinase, connexins and matrix metalloproteinases all appear promising biological markers associated with the early stage metastatic process in prostate cancer. Here we discuss their potential to become valid biological markers based on literature data. Thus far, none of these markers proved to be a valid individual marker by itself due to prostate cancer heterogeneity and transient expression. Analyzing a combination of the potential markers discussed in this review is expected to be a better approach toward discriminating high-from low-risk tumors in an early stage of prostate cancer.

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Section: E-cadherinmentioning

confidence: 63%

New experimental markers for early detection of high-risk prostate cancer: role of cell–cell adhesion and cell migration

Mól

Geldof

Meijer

et al. 2007

J Cancer Res Clin Oncol

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“…In the current case-control study, associations of three CDH1 polymorphisms (-160 C>A, rs16260; -347 G>GA, rs5030625; +54 C>T, rs1801026) and cancer risk were estimated. The polymorphisms of CDH1 may play a critical role in the tumorigenesis, development and prognosis of sever kinds of cancer, such as colorectal cancer, gastric cancer, prostate cancer, breast cancer and esophageal cancer (Lei et al, 2002;Jonsson et al, 2004;Medina-Franco et al, 2007;Zhang et al, 2007;Li et al, 2011). Therefore, we performed this meta-analysis to estimate the associations between CDH1 polymorphisms and cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

Deng¹,

He²,

Pan³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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E-Cadherin (CDH1) genetic variations may be involved in invasion and metastasis of various cancers by altering gene transcriptional activity of epithelial cells. However, published studies on the association of CDH1 gene polymorphisms and cancer risk remain contradictory, owing to differences in living habits and genetic backgrounds. To derive a more better and comprehensive conclusion, the present meta-analysis was performed including 57 eligible studies of the association between polymorphisms of CDH1 gene promoter -160 C>A, -347 G>GA and 3'-UTR +54 C>T and cancer risk. Results showed that these three polymorphisms of CDH1 were significantly associated with cancer risk. For -160 C>A polymorphism, -160A allele carriers (CA and CA+AA) had an increased risk of cancer compared with the homozygotes (CC), and the similar result was discovered for the -160A allele in the overall analyses. In the subgroup analyses, obvious elevated risk was found with -160A allele carriers (AA, CA, CA+AA and A allele) for prostate cancer, while a decreased colorectal cancer risk was shown with the AA genotype. For the -347 G>GA polymorphism, the GAGA genotype was associated with increased cancer risk in the overall analysis with homozygous and recessive models. In addition, results of subgroup analysis indicated that the elevated risks were observed in colorectal cancer and Asian descendants. For +54 C>T polymorphism, a decreased risk of cancer was found in heterozygous, dominant and allele models. Moreover, +54T allele carriers (CT, CT+TT genotype and T allele) showed a potential protective factor in gastric cancer and Asian descendants.

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“…A report of the E-cadherin -160 C/A polymorphism in prostate cancer found that 'A' allele carriers had a higher risk of prostate cancer compared with 'C' allele carriers [15] . Jonsson et al [14] who studied Swedish patients with hereditary prostate cancer also found a higher risk among 'A' allele carriers. However, the association between 'A' allele carriers and prostate cancer was not found in sporadic or familial prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Genetic polymorphisms such as CDH-1 gene have been reported to be associated with risk of developing many types of cancer [13][14][15] . A report of the E-cadherin -160 C/A polymorphism in prostate cancer found that 'A' allele carriers had a higher risk of prostate cancer compared with 'C' allele carriers [15] .…”

Section: Discussionmentioning

confidence: 99%

E-Cadherin Gene 3′-UTR C/T Polymorphism Is Associated with Prostate Cancer

Lai

et al. 2005

Urol Int

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Introduction: E-cadherin (CDH-1) is a cell-cell adhesive molecule which maintains cell integrity and communication between the intracellular and extracellular world. CDH-1 may therefore be related to carcinogenesis. A polymorphism located at the 3′-UTR of the CDH-1 gene is associated with stone disease; however, its relationship to prostate cancer has not been reported. We aimed to study whether there is an association between the 3′-UTR polymorphism and prostate cancer. Materials and Methods: We collected 96 patients with prostate cancer and 114 normal controls for this study. The polymorphism of the CDH-1 gene was studied by polymerase chain reaction-based restriction analysis. Results:There was a significant difference in genotype distribution of the CDH-1 gene polymorphism between cancer patients and normal controls (p < 0.001). The distribution of the CDH-1 gene CC genotype in prostate cancer patients (51.0%) was higher than in the controls (10.5%). The odds ratio for the CDH-1 ‘C’ allele was 2.896 (95% CI = 1.908–4.396). There was no significant difference according to age, pathological grading, clinical staging, and responsiveness to hormonal therapy among patients. Only 3 patients (3.1%) had a history of urolithiasis. Conclusions:The CDH-1 gene 3′-UTR C/T polymorphism is associated with prostate cancer. The ‘CC’ homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes.

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−160C/A polymorphism in the E‐cadherin gene promoter and risk of hereditary, familial and sporadic prostate cancer

Cited by 45 publications

References 33 publications

New experimental markers for early detection of high-risk prostate cancer: role of cell–cell adhesion and cell migration

New experimental markers for early detection of high-risk prostate cancer: role of cell–cell adhesion and cell migration

Roles of E-Cadherin (CDH1) Genetic Variations in Cancer Risk: a Meta-analysis

E-Cadherin Gene 3′-UTR C/T Polymorphism Is Associated with Prostate Cancer

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