E-Cadherin Gene 3′-UTR C/T Polymorphism Is Associated with Prostate Cancer

Abstract

Introduction: E-cadherin (CDH-1) is a cell-cell adhesive molecule which maintains cell integrity and communication between the intracellular and extracellular world. CDH-1 may therefore be related to carcinogenesis. A polymorphism located at the 3′-UTR of the CDH-1 gene is associated with stone disease; however, its relationship to prostate cancer has not been reported. We aimed to study whether there is an association between the 3′-UTR polymorphism and prostate cancer. Materials and Methods: We collected 96 patients with prostate cancer and 114 normal controls for this study. The polymorphism of the CDH-1 gene was studied by polymerase chain reaction-based restriction analysis. Results:There was a significant difference in genotype distribution of the CDH-1 gene polymorphism between cancer patients and normal controls (p < 0.001). The distribution of the CDH-1 gene CC genotype in prostate cancer patients (51.0%) was higher than in the controls (10.5%). The odds ratio for the CDH-1 ‘C’ allele was 2.896 (95% CI = 1.908–4.396). There was no significant difference according to age, pathological grading, clinical staging, and responsiveness to hormonal therapy among patients. Only 3 patients (3.1%) had a history of urolithiasis. Conclusions:The CDH-1 gene 3′-UTR C/T polymorphism is associated with prostate cancer. The ‘CC’ homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes.

TheBRCA13′-UTR: 5711+421T/T_5711+1286T/T Genotype Is a Possible Breast and Ovarian Cancer Risk Factor

“…For example, 3 0 -UTR variations of both COX-2 and CYP2A6 are associated with an increased risk of lung cancer in Korean and Swedish populations, respectively (Park et al, 2006;Wang et al, 2006). Similarly, changes of the 3 0 -UTR of CDH-1 and Urokinase have been found to be associated with an increased risk of prostate cancer in Taiwanese and Indian populations (Mittal et al, 2005;Wu et al, 2005). Variations within the 3 0 -UTR sequences of the TYMS, DHFR, STK15, NPRA, CYP1A1, and BRCA1 genes have also been reported to be associated with an increased risk of specific cancers (Newman et al, 1998;Goto et al, 2001;Sarzani et al, 2003;DiCioccio et al, 2004;Zhang et al, 2005;Shin et al, 2007).…”

DNA Variation in MSR1, RNASEL and E-Cadherin Genes and Prostate Cancer in Poland

“…A missense variant in E-cadherin, S270A, was reported to be associated with prostate cancer risk in Finland [29] and 3 -untranslated region C/T polymorphism in Taiwan [30] . The most extensively studied variant, the -160C 1 A promoter polymorphisms, has been associated with increased prostate cancer risk in the Netherlands, Sweden and USA (carriers of AA, AC genotypes were found to be at higher cancer risk than carriers of CC genotype) [9,10,[31][32][33] .…”

Association of three single nucleotide polymorphisms of the E-cadherin gene with endometriosis in a Chinese population

“…Although the function of the 3 0 -UTR C54 C/T polymorphism was unclear, studies have showed that this polymorphism was associated with cancer and other diseases (Tsai et al 2003, Wu et al 2005, Lin et al 2006. Wu et al found that the 'CC' homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes (Lin et al 2006).…”

“…These polymorphisms were associated with the development and progression of a certain cancer (Verhage et al 2002, Shin et al 2004a, Wu et al 2005. The relation between E-cadherin gene polymorphisms and the risk of developing endometriosis has not been reported.…”