1404 Prospects of Probiotic Bacterial Lectins in Medicine

Abstract

Methods A retrospective audit was performed over 6 months (Jan 2011-June 2011) period. Management of all breastfed infants admitted with weight loss (>7% of birth weight) with or without other clinical symptoms of dehydration were reviewed. Information was collected from infant clinical notes, discharge summaries, hospital pathology reporting system and maternal notes. Results 1908 infants were born during this period, 33 infants (1.73%) required readmissions. No risk factor was identified in 3 infants, 30 infants had one or more risk factors, commonest being caesarean section delivery (61%) followed by infants born to 'first time mother's (33%). 72% of the infants developed jaundice. Majority of the infants(59%) were managed with breast feeding support only whereas 15% needed intravenous fluid support. Most infants (69.6%) were discharged within 48 hrs of admission. Half of the infants developing hypernatremia had comparatively mild weight loss (≤10% of birth weight). Conclusions Weight loss and Hypernatremia continues to be a problem in neonates particularly in 'at risk' infants. Most of these infants responded well to enteral feeding only. Degree of hypernatremia was not always proportion to the degree of weight loss.

Metabolite Multiprobiotic Formulas for Microbial Health

“…Pro-/sym-/synbiotics are important objects of human microecology and medical biotechnology [1][2][3][4]. Microbes and human communicate each other by the way of recognition and binding glycoconjugates (GC) of varying pattern complexity by proteins (mainly adhesions and lectins) [5][6][7][8][9]. Lectin systems (LS) of symbiotic/ probiotic microorganisms (LSSM) recognizing GC represent new multifunctional factors [8][9][10][11][12].…”

“…Microbes and human communicate each other by the way of recognition and binding glycoconjugates (GC) of varying pattern complexity by proteins (mainly adhesions and lectins) [5][6][7][8][9]. Lectin systems (LS) of symbiotic/ probiotic microorganisms (LSSM) recognizing GC represent new multifunctional factors [8][9][10][11][12]. LSSM are relatedly useful for human protein-/peptide-containing compounds and their complexes recognizing GC.…”

Lectin Systems Imitating Probiotics: Potential and Prospects for Biotechnology and Medical Microbiology

“…keeping metabolome status; -switching (on/off) microbial nets and cascades; -controlling microbiocenosis functioning; providing cell teaching; -factors in constructing of beneficial microbiocenoses; -directed antipathogen action by changing ontogenesis of pathogens) [27]; -helpers in building cell and cytokine-like gradients [23]; -synergistic and synbiotic factors in mixed cultures of microorganisms or in host biotopes [32]; -stabilizers of poorly growth probiotic microorganisms [35,36]; -co-functioning with other PBL-like and non-PBL antimicrobials produced by probiotic compartment of biotope (bacteriocins, antimicrobial peptides and biosurfactants) [22,39] -co-functioning with human cytokines (PBL as cytokine inducers), defensins, antibiotics (synergism), antibodies [9,39,40]; -synergism of PBL signaling and signal proteinases/oligopeptidases and (oligo)peptides of surrounding; -screening, selection and typing of strains; -ingredients of both free cell drug ointments and cosmetic creams (improving formulas) [39,41]; -in recombinant lectin technologies [17]; -carriers for drug delivery, carriers of low molecular weight highly hydrophobic heterocyclic effectors (some antibiotics, chemotherapeutic antitumor agents, apoptose inducers, etc.) [3,17]; -ingredients of functional bioadditives [41];…”

“…The role of such LL may be in regulation of protection of probiotic consortium in biotopes against peroxide stress. Examples of regulation of oxidoreductases with lectins are well documented [15]. Mean time, the role of neutral LL is still unclear.…”

“…Lectins are represented by more than 20 families and large groups involving in regulation of metabolism and widely used in biotechnology [5,7,8,13,15,17]. Symbiotic microbial lectins are important regulators of relationships between microbes and eukaryotic macroorganisms [16].…”