Lectin Systems Imitating Probiotics: Potential and Prospects for Biotechnology and Medical Microbiology

Metabolite Multiprobiotic Formulas for Microbial Health

“…The used GC are characterized with known chemical structures simplifying interpretation and prognostics of results. Such GC reveal potential of metabiotics which may use LSSM as carriers [8,12,19]. As highly homogenous, synthetic GC better functionally imitate natural GC targets [bacterial proteoglycans, fungal (phosphor)mannans, others] important for antimicrobial/anti-infectious actions of LSSM.…”

“…Important prospects in constructing taxonomically mixed symbiotic formulas are expected on the basis of identified LSSM sets of the strains as counted ingredients of multisymbiotic as well as evaluation of the relative contribution of LSSM types in resulting multifunctional activities of mixed product. For example, the general properties of LS of lactobacilli and bifidobacteria investigated by us are "recognition of mucin-type targets" more or less than "recognition of mannan-type targets" for LL or BL, respectively [8]. As a result, LSSMdependent synergism (which can be directed and predicted using extended panel of GC for LSSM selection and choice) of new taxonomically mixed symbiotics can be achieved.…”

“…Pro-/sym-/synbiotics are important objects of human microecology and medical biotechnology [1][2][3][4]. Microbes and human communicate each other by the way of recognition and binding glycoconjugates (GC) of varying pattern complexity by proteins (mainly adhesions and lectins) [5][6][7][8][9]. Lectin systems (LS) of symbiotic/ probiotic microorganisms (LSSM) recognizing GC represent new multifunctional factors [8][9][10][11][12].…”

“…Microbes and human communicate each other by the way of recognition and binding glycoconjugates (GC) of varying pattern complexity by proteins (mainly adhesions and lectins) [5][6][7][8][9]. Lectin systems (LS) of symbiotic/ probiotic microorganisms (LSSM) recognizing GC represent new multifunctional factors [8][9][10][11][12]. LSSM are relatedly useful for human protein-/peptide-containing compounds and their complexes recognizing GC.…”

“…LSSM are relatedly useful for human protein-/peptide-containing compounds and their complexes recognizing GC. LSSM reveal features of imitators of probiotics; members of new class of bacteriocin-like destructors of biofilms of yeast-like fungal and Gram-positive pathogens; systems cofunctioning together with enzymes of all known classes; and agents possessing antipathogenic synergism of different LS in antimicrobial combinations (between LS of Lactobacillus species and Bifidobacterium species, between genera Lactobacillus and Bifidobacterium, between LS of probiotic bacteria and lectins from medical plants, between LSSM and antibiotics) (see Table 2) [8,9,13,14].…”