14-MHz Ultrasonography as an Outcome Measure in Morphea (Localized Scleroderma)

Nezafati, Kaveh A.

doi:10.1001/archdermatol.2011.243

Cited by 41 publications

(43 citation statements)

References 6 publications

(8 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Echographic images of SSc patients skin differed from healthy controls [6]. The degree of skin echogenicity correlated with the amount of sclerosis on histologic examination [7]. During the oedematous phase, skin echogenicity was low and skin thickness was high.…”

Section: Introductionmentioning

confidence: 99%

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

Hou

Zhu

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

ObjectiveTo evaluate the usefulness of skin ultrasound and acoustic radiation force impulse (ARFI) quantification in diffuse cutaneous systemic sclerosis (dcSSc).Patients and methods28 patients with dcSSc, and 15 age gender matched normal controls were recruited. Skin echogenicity, thickness, and ARFI quantification were measured by ultrasound at 17 sites corresponding to the modified Rodnan skin score (mRSS) in each participant. Compared with controls, skin echogenicity of dcSSc patients was classified into isoechoic, hypoechoic, and hyperechoic. The skin thickness, ARFI quantification and mRSS were compared between isoechoic, hypoechoic, hyperechoic and controls.ResultsIn patients with dcSSc, the skin thickness increased as the echogenicity changed on the order of isoechoic, hypoechoic and hyperechoic. ARFI quantification was significantly higher in hyperechoic than isoechoic (p<0.001). The mRSS were significantly higher in hyperechoic and/or hypoechoic than isoechoic. For isoechoic patients and healthy controls, the skin echogenicity or thickness was no significant different, however, the ARFI quantification was significantly higher in isoechoic than controls.ConclusionSkin ultrasound is feasible for assessing the skin involvement in dcSSc. Skin echogenicity correlates with skin thickness, stiffness, and mRSS. ARFI quantification may be more sensitive to detect skin changes, compared with skin echogenicity and thickness.

show abstract

Section: Introductionmentioning

confidence: 99%

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

Hou

Zhu

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Ultrason deri ve subkütan doku tabakalarını tanımlamaya yardımcı olmakla beraber sistemik skleroz ve lokalize skleroderma gibi fibrozan hastalıkların araştırmalarında, ve dermis kalınlığı incelemelerinde yüksek sensitiviteye sahip olduğu bilinmektedir (6)(7)(8)(9)(10)(11)(12). Dört bin üç yüz otuz sekiz morfea deri lezyonu ve 130 sağlıklı kontrol hastasını kapsayan retrospektif bir çalışmada lezyonların %73'ünde mevcut tanısal doğruluk oranının 14-15 MHz yüksek rezolüsyonlu USG kullanımı ile %97'ye yükseldiği saptanmıştır (6).…”

Section: Discussionunclassified

“…Literatürde lokalize morfealı olgularda klinik inceleme (doku elastisistesi), mRSS, histopatolojik veriler ve düşük frekanslı ultrasonografik incelemenin korelasyonunu araştıran bir yayında klinik olarak inflamatuvar olan lezyonlar kontrol lezyonlar ile benzer; izoekoik, sklerotik karakterdeki morfea lezyonları; hiperekoik ve atrofik olanlar ise; hipoekoik olarak saptanmıştır (7). Bu çalışmada morfea lezyonlarında aktif dönemde dokuda incelme, hiperemi, artmış ekojenite ve subkütan yağ ve kas doku kaybı gibi bulgular görüldüğü rapor edilmiştir.…”

Section: Discussionunclassified

“…Diğer bir çalışmada ise; 14 plak morfea hastasının 16 lezyonunda ultrasonografik olarak hiperkojenite ile dermatolojik incelemedeki orta ya da şiddetli dereceli skleroz arasında anlamlı oranda ilişki olduğu bulunmuş olsa da ultrasonografik olarak ölçülen sklerozun derinliği ile histopatolojik analizler arasında anlamlı ilişki saptanmamıştır (7). Aynı çalışmada mRSS, ekojenite ve ultrasonografik dermal kalınlık arasında bir ilişki olmayışı, mRSS'nin klinisyenin deriyi germe tekniğine dayalı olduğundan yetersiz ve subjektif olduğu sonucunu da doğurmaktadır (7). USG'nin morfea aktivitesinin değerlendirmesinde klinik bulgular ya da laboratuvar incelemelerden daha duyarlı olduğu düşünülmektedir (11).…”

Section: Discussionunclassified

“…Biz bu çalışma ile aynı zamanda doku kalınlığı ile kalınlık skoru, elastisite indeksi, elastisite oranı, ekojenite skoru ve vaskülarite skoru arasındaki olası bir ilişkinin varlığını da araştırmış olduk. Önceki çalışmalara benzer şekilde morfea plaklarında normal dokuya oranla dermis ve hipodermis kalınlığında belirgin azalmanın yanısıra, dermisde elastisite oranında düşüş görülmesi beklenen bir durumdu (7,11,12 Hasta Onayı: Çalışmamıza dahil edilen tüm hastalardan bilgilendirilmiş onam formu alınmıştır.…”

Section: Discussionunclassified

See 2 more Smart Citations

Low Frequency Ultrasonography in Plaque-Type Morphea

Balevi¹,

Eren²,

Üstüner³

et al. 2017

tdd

View full text Add to dashboard Cite

Amaç: Düşük frekanslı ultrasonografik incelemenin lokalize sklerodermada deri tabakalarını ve dokuların perfüzyon paternlerini belirleyen başarılı bir yardımcı teknik olduğu düşünülmektedir. Histopatolojik olarak morfea tanısı olan olgularda lezyonlu derinin kalınlığı, elastisitesi, ekojenitesi ve vaskülaritesi gibi temel parametrelere bakılarak düşük frekanslı ultrason tekniğinin klinik takipteki rolünün belirlenmesi amaçlanmıştır. Objective: Low frequency ultrasonographic examination is thought to be a successful adjuvant technique for determination of skin layers and tissue perfusion patterns in localized scleroderma. We aimed to identify the role of this technique in the clinical follow-up via investigation of basic parameters such as skin thickness, elasticity, echogenicity and vascularity in patients diagnosed with morphea by histopathology. Methods: Thirty-five plaque lesions of nineteen patients with morphea and symmetric, uninvolved cutaneous areas were compared by ultrasound in terms of mean skin thickness, elasticity index and elasticity ratio. The associations between the skin thickness and thickness score, elasticity score and elasticity index, echogenicity score and vascularity score were investigated in all tissue levels. Results: Of the morphea lesions, while the mean dermal skin thickness and dermal elasticity ratio were decreased compared to normal skin, the dermal vascularity was solely increased with an increase of the tissue thickness. Only the mean skin thickness was found to be significantly lower compared to the normal skin areas in the hypodermis of the morphea plaque lesions. Conclusion: Low frequency ultrasound can be used as an effective, adjuvant technique in the clinical follow-up of morphea plaque lesions in the levels of dermis and hypodermis.

show abstract

Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea

Shaw,

Nguyen,

Rajeh

et al. 2023

JAMA Dermatol

View full text Add to dashboard Cite

ImportanceObjectively determining disease progression in craniofacial morphea (CM) is challenging, as clinical findings of disease activity are often lacking.ObjectiveTo evaluate the utility of 3-dimensional (3D) stereophotogrammetry in detecting disease progression in CM over time.Design, Setting, and ParticipantsThis prospective cohort study included 27 pediatric and adult patients with CM from 2 hospitals in Boston (Boston Children’s Hospital and Brigham &amp; Women’s Hospital) consecutively enrolled from April 1, 2019, to March 1, 2023. Review of 3D stereophotogrammetry images and data analysis occurred from March 1 to April 1, 2023.Main Outcomes and MeasuresClinical and 3D stereophotogrammetry assessments were performed at 2- to 12-month intervals, depending on the clinical context. The 3D stereophotogrammetry images were then qualitatively rated as demonstrating no progression or definitive progression by an expert (board-certified plastic craniofacial surgeon) and nonexpert (board-certified dermatologist) in 3D stereophotogrammetry. In addition, κ coefficients were calculated for interrater reliability.ResultsOf 27 patients with CM (19 female; median age, 14 [range, 5-40] years) and 3D stereophotogrammetry images obtained from a minimum of 2 time points (median, 4 [range, 2-10] images) spaced a median of 3 (range, 2-12) months apart, 10 experienced progression of their disease based on clinical assessments performed during the study period. In all cases in which clinical progression was favored, blinded qualitative assessment of 3D stereophotogrammetry images also favored progression with substantial interrater reliability (κ = 0.80 [95% CI, 0.61-0.99]). Furthermore, review of 3D stereophotogrammetry detected occult progression of asymmetry not noted on clinical examination in 3 additional patients.Conclusions and RelevanceIn this prospective cohort study, blinded assessment of sequential 3D stereophotogrammetry images in patients with CM not only corroborated clinical assessment of disease progression but also detected occult progression of facial asymmetry not appreciable on clinical examination alone. Therefore, 3D stereophotogrammetry may serve as a useful adjunct to clinical examination of patients with CM over time. Future investigations are warranted to validate 3D stereophotogrammetry as an outcome measure in CM.

show abstract

14-MHz Ultrasonography as an Outcome Measure in Morphea (Localized Scleroderma)

Abstract: Author Contributions: All authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.

Cited by 41 publications

References 6 publications

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

A preliminary study of skin ultrasound in diffuse cutaneous systemic sclerosis: Does skin echogenicity matter?

Low Frequency Ultrasonography in Plaque-Type Morphea

Use of 3-Dimensional Stereophotogrammetry to Detect Disease Progression in Craniofacial Morphea

Contact Info

Product

Resources

About