[13C]octanoic acid breath test for gastric emptying of solids: Meal-to-meal variability

Hildebrand, Pius; Drewe, J.; Degen, Lukas; Beglinger, Christoph

doi:10.1016/s0016-5085(98)83128-4

Cited by 2 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Mathematische Modelle, die versuchen, aus der Exhalationskinetik auf die tatsächliche Magenentleerungskinetik zu schließen, wurden inzwischen bei Gesunden evaluiert (Linearmodell [174,177,179], Dekonvolutionsmodell [182]). Andererseits konnte gezeigt werden, dass sowohl die intraindividuelle Variabilität (Reproduzierbarkeit: lag period 14 -15 %, Halbwertzeit 11 -12 %) als auch die interindividuelle Variabilität (lag period 20 -22 %, Halbwertzeit 20 -24 %) des 13 C-Oktansäure-Atemtests der Variabilität der szintigraphisch gemessenen Entleerung (intra-individuell 14 -19 %, interindividuell 38 -41 %) entsprechen [180,183,184]. Die Variabilität des 13 C-Oktansäure-Atemtests reflektiert somit im Wesentlichen die Variabilität der Magenentleerung.…”

Section: Erläuterungenunclassified

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Keller

Franke²,

Storr³

et al. 2005

Z Gastroenterol

View full text Add to dashboard Cite

H (2)- and (13)C-breath tests are valuable non-invasive diagnostic tools for gastroenterological diseases. H (2)-breath tests are clinically established for the diagnosis of carbohydrate intolerance resulting from malabsorption (H (2)-breath tests with lactose, fructose, saccharose, sorbitol), of bacterial overgrowth (glucose H (2)-breath test) and for measurement of orcoceal transit time (lactulose H (2)-breath test). The (13)C-urea breath test is regarded as the "gold standard" procedure for the diagnosis of Helicobacter pylori infection. Moreover, (13)C-breath tests for measurement of gastric emptying can be considered as clinically established, meanwhile. (13)C-breath tests for the evaluation of pancreatic exocrine function or liver function can also be used clinically; however, they currently offer no substantial advantage over other diagnostic procedures. A major disadvantage of all breath tests is that they lack standardization although modifications of the test meal or solution, of the test performance and of the evaluation of data may markedly influence the results. Thus, this article presents the recommendations of the German Society of Neurogastroenterology and Motility and of the German Society of Digestive and Metabolic Diseases for clinically relevant H (2)- and (13)C-breath tests. Indications for the examinations, the procedures to be followed, the analysis of the obtained data and the conclusions to be drawn are delineated. The literature on which the recommendations are based is reviewed. However, personal experience of the authors is also taken into account since numerous questions regarding optimal test performance are not clarified by adequate studies.

show abstract

Section: Erläuterungenunclassified

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Keller

Franke²,

Storr³

et al. 2005

Z Gastroenterol

View full text Add to dashboard Cite

show abstract

Delayed gastric emptying determined using the ¹³C–octanoic acid breath test in patients with systemic sclerosis

Marie

Gourcerol

Leroi

et al. 2012

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To determine the prevalence of delayed gastric emptying using the 13 C-octanoic acid breath test in unselected patients with systemic sclerosis (SSc), to evaluate whether findings of the 13 C-octanoic acid breath test are associated with clinical digestive manifestations, gastric mucosal abnormalities detected by gastroscopy, motor activity dysfunction detected by antroduodenal manometry, and esophageal motor impairment and extradigestive manifestations of SSc, and to develop a risk prediction score of gastric emptying in SSc.Methods. Consecutive patients with SSc (n ‫؍‬ 57) underwent the 13 C-octanoic acid breath test. All of the patients with SSc completed a questionnaire on digestive symptoms, and a global symptom score (GSS) was calculated.Results. The prevalence of delayed gastric emptying was 47.4% in patients with SSc. A marked correlation was observed between a GSS of digestive symptoms >5 and the presence of delayed gastric emptying (P < 0.00001). The sensitivity of a GSS >5 for predicting delayed gastric emptying was as high as 0.93, while the specificity was 0.73. Moreover, a GSS >5, mucosal gastric abnormalities, severe esophageal motor impairment, and interstitial lung disease were factors that were independently associated with the presence of delayed gastric emptying, and these variables were used to create a risk prediction score. The area under the receiver operating characteristic curve for the risk prediction score was 0.90; the sensitivity of this score for the prediction of delayed gastric emptying was 0.93, while the specificity was 0.77. Conclusion.The results indicate that delayed gastric emptying occurs often in patients with SSc. Interestingly, using risk models with routine clinical characteristics, a simple risk prediction score can be calculated, allowing prediction of the occurrence of delayed gastric emptying in patients with SSc.

show abstract

[13C]octanoic acid breath test for gastric emptying of solids: Meal-to-meal variability

Cited by 2 publications

References 0 publications

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Delayed gastric emptying determined using the ¹³C–octanoic acid breath test in patients with systemic sclerosis

Contact Info

Product

Resources

About

[13C]octanoic acid breath test for gastric emptying of solids: Meal-to-meal variability

Cited by 2 publications

References 0 publications

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Klinisch relevante Atemtests in der gastroenterologischen Diagnostik - Empfehlungen der Deutschen Gesellschaft für Neurogastroenterologie und Motilität sowie der Deutschen Gesellschaft für Verdauungs- und Stoffwechselerkrankungen

Delayed gastric emptying determined using the 13C–octanoic acid breath test in patients with systemic sclerosis

Contact Info

Product

Resources

About

Delayed gastric emptying determined using the ¹³C–octanoic acid breath test in patients with systemic sclerosis