13C-octanoic acid breath test for gastric emptying measurement

Delbende, Bruno; Perri, Francesco; Couturier, O.; Leodolter, Andreas; Mauger, P.; Bridgi, Boumediene; Bizais, Y.; Varannes, Stanislas Bruley des; Andriulli, Angelo; Galmiche, Jean Paul

doi:10.1097/00042737-200012010-00016

Cited by 80 publications

(97 citation statements)

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“…For example, in a human Accordingly, there exists the further potential for Iberogast ® to improve tissue morphology in even more proximal regions of the digestive tract, such as the stomach. Using non-invasive techniques including the lactulose breath test, indicative of small intestinal transit time, 39 and the 13 C-octanoic breath test, 40 which measures formation of free radicals. 18 Using an in vitro system of MPO driven oxidative stress, Schempp et al found that Iberogast ® inhibited MPO-catalysed oxidant formation by 33%.…”

Section: Discussionmentioning

confidence: 99%

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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There is an acute need for the development of effective therapies for mucositis, a debilitating side effect of cancer chemotherapy. Iberogast ® is a herbal extract reported to possess anti-inflammatory properties. We investigated Iberogast ® for its potential to reduce the severity of 5-Fluorouracil (FU)-induced mucositis in rats. Rats were allocated to three treatment groups (n = 8) and gavaged daily with a 10% solution of Iberogast ® or water from day 0 to day 8. Rats were injected intraperitoneally with 5-FU (150 mg/kg) or saline on day 6, and killed after 72 h. In vivo and in vitro sucrase activity was assessed by 13 C-sucrose breath test (SBT) and sucrase assay respectively. Intestinal disease severity was determined by histological assessment of villus height and crypt depth. Significant increases in villus height (277 ± 9 μm) and crypt depth (67 ± 3 μm) were observed in 5-FU + Iberogast ® -treated rats compared with 5-FU + Water (224 ± 13 μm and 48 ± 2 μm respectively; p < 0.05). Sucrase activity was significantly reduced in all 5-FU groups compared to control. Significant reductions in SBT and sucrase activity were observed in all 5-FU groups compared with Saline + Water controls (p < 0.05). We conclude that although Iberogast ® partially improved the histopathological features of 5-FU induced mucositis, it conferred no significant protection as indicated by the assessed endpoints.

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Section: Discussionmentioning

confidence: 99%

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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“…A standardized 13 C-octanoic acid breath ( 13 C-OABT) test was performed in all subjects. The test meal consisted of an omelet (1 egg, yolk doped with 91 mg 13 C-octanoic acid, purchased from Eurisotop, Saarbruecken, Germany), 50 g ham, 2 slices of white bread, 10 g butter, and 200 ml orange juice (13,24).…”

Section: Performance and Reliability Of Gastric Emptying Testmentioning

confidence: 99%

“…The test meal consisted of an omelet (1 egg, yolk doped with 91 mg 13 C-octanoic acid, purchased from Eurisotop, Saarbruecken, Germany), 50 g ham, 2 slices of white bread, 10 g butter, and 200 ml orange juice (13,24). Breath samples were obtained before ingestion of the meal, at 15-min intervals up to 240 min and 270 and 300 min postprandially.…”

Section: Performance and Reliability Of Gastric Emptying Testmentioning

confidence: 99%

Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract

Keller

Beglinger

Holst

et al. 2009

American Journal of Physiology-Gastrointestinal and Liver Physi

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“…Postprandial gastric motility is assessed either by quantifying gastric emptying time and/or gastric antral motility or by detecting the electrical excitement caused by gastric movement. Gastric emptying can be evaluated using scintigraphy [1,14], a 13 Coctanoic acid breath test [8,31], or radiopaque markers [18,27], whereas gastric antral motility is examined using force transducers [13] or abdominal ultrasonography [5,7,9,19].…”

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confidence: 99%

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

Tsukamoto

Ohno

Tsukagoshi

et al. 2011

The Journal of Veterinary Medical Science

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ABSTRACT. Gastric motility is affected by several pathological conditions which may induce upper gastrointestinal clinical symptoms. The pathogenesis of canine gastric motility disorders is poorly understood because of methodological limitations. This study aimed at establishing a simple method for evaluating postprandial gastric motility in dogs. Gastric motility was ultrasonographically assessed in 7 healthy beagles using a technique previously described in humans. The motility index (MI), an indicator of gastric antral motility, was calculated by measuring the area of the gastric antrum in both a contracted and relaxed phase and by counting the number of contractions. The MI was measured every 30 min for 3 hr after feeding and compared with gastric emptying as assessed by a 13 C-octanoic acid breath test. The MI at 30 min had the lowest variability in the 7 dogs (mean ± SD, 9.77  0.42; coefficient of variance, 4.25%), and a significant correlation was observed with gastric emptying coefficient (R 2 =0.8126, P=0.005) and half-emptying time (R 2 =0.654, P=0.027). When atropine was administered, a significant decrease in the MI at 30 min was observed compared with the control (9.77  0.42 vs. 5.19  0.22, P=0.0003). In conclusion, evaluation of the MI at 30 min is suitable for assessing gastric motility and enables us to assess gastric motility simply in a short time. By using this method, further studies for the pathogenesis of canine gastric motility disorders are warranted.KEY WORDS: 13 C-octanoic acid breath test, canine, gastric motility, motility index, ultrasonography.J. Vet. Med. Sci. 73(9): 1133-1138, 2011 Gastric motility disorders are caused secondary by several diseases or drug administration and possibly related with the pathogenesis of upper gastrointestinal clinical symptoms such as anorexia, vomiting, abdominal pain, and emesis. Several methods for evaluating gastric motility in both humans and dogs have been described [25,29]. Gastric motor activity has 2 characteristic phases: fasting and the postprandial phase. Many of the previous studies have focused on the postprandial phase. Postprandial gastric motility is assessed either by quantifying gastric emptying time and/or gastric antral motility or by detecting the electrical excitement caused by gastric movement. Gastric emptying can be evaluated using scintigraphy [1,14], a 13 Coctanoic acid breath test [8,31], or radiopaque markers [18,27], whereas gastric antral motility is examined using force transducers [13] or abdominal ultrasonography [5,7,9,19].Of these methods, scintigraphy is considered the gold standard for evaluating gastric emptying in both humans and dogs [22,29]. However, it requires a specialized facility and exposure to radiation. The 13 C-octanoic acid breath test is an indirect method of assessing gastric emptying using a non-radioisotope-labeled substrate. The test involves monitoring the rate of 13 CO 2 in expired air following ingestion of a test meal mixed with 13 C-octanoic acid. The 13 C-octanoic acid breath test has ...

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13C-octanoic acid breath test for gastric emptying measurement

Cited by 80 publications

References 0 publications

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Mechanisms of gastric emptying disturbances in chronic and acute inflammation of the distal gastrointestinal tract

Real-Time Ultrasonographic Evaluation of Canine Gastric Motility in the Postprandial State

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