125I-LSD autoradiography confirms the preferential localization of caudate-putamen S2 receptors to the caudal (peripallidal) region

Serotonin 2A and 2C receptor biosynthesis in the rodent striatum during postnatal development: mRNA expression and functional linkage to neuropeptide gene regulation

“…Our present data, representing the first region-specific analyses of striatal 5-HT 2A and 5-HT 2C receptor mRNA expression during postnatal development, show 5-HT 2A receptor mRNA levels predominated in the P-STR while 5-HT 2C receptor mRNA levels were greater in the A-STR throughout postnatal development, confirming a well-established gradient in the adult rodent striatum (Altar et al, 1986;Ward and Dorsa, 1996). In addition to showing gross anatomical differences in striatal localization, Ward and Dorsa (1996) also suggested that 5-HT 2A receptors are preferentially expressed in the striatal matrix, while 5-HT 2C receptors may be located in striatal patch compartments.…”

“…Moreover, pCA (Moorman and Leslie, 1996) and DOI (Leslie and Moorman, 1993;Moorman and Leslie, 1996) increased striatal c-fos immunoreactivity which was prevented by the 5-HT 2 receptor antagonist ritanserin. While 5-HT 2 receptors appear to be positively coupled to striatal PPT mRNA expression (Gresch and Walker, 1999a,b;Walker et al, 1991Walker et al, , 1996, increases in PPT mRNA levels are largely isolated to the P-STR under normal conditions where 5-HT 2A receptors predominate (Altar et al, 1986;Ward and Dorsa, 1996) and are colocalized with PPT containing neurons (Ward and Dorsa, 1996) of the direct striatonigral output pathway. Whole brain analysis of 5-HT 2 receptor expression has demonstrated mRNA and protein levels to significantly increase during postnatal development (Roth et al, 1991).…”

“…Given that 5-HT 2A receptors are expressed at higher levels in the P-STR (Altar et al, 1986;Ward and Dorsa, 1996), are colocalized with striatal PPT-containing neurons of the direct striatonigral output pathway (Ward and Dorsa, 1996), and are positively coupled to PPT mRNA regulation (Gresch and Walker, 1999a;Walker et al, 1991Walker et al, , 1996, we hypothesized that acute pCA treatment stimulates PPT mRNA expression via 5-HT 2A receptors. Our previous data suggested that 5-HT may influence striatal neuropeptide gene expression in a region-specific manner based on the possibility that 5-HT 2A receptors are present at higher concentrations in the P-STR vs. A-STR during the first month of postnatal development.…”

Chronic treatment with clozapine or haloperidol differentially regulates dopamine and serotonin receptors in rat brain

“…In contrast, the anatomical localization of the rece tors on which CLZ acts suggests that this drug shoul have a eater impact on the HAL. For instance, 5-HTz receptors are found in abundance in the ventral striatum (Altar et al, 1985a(Altar et al, , 1986a and in the frontal cortex (Altar et al, 1985a), areas with extensive limbic connections. Also, D1 receptors are present in greater density in frontal cortex than are D, receptors (Richfield et al, 1989), and even the striatal distribution of D1 and D, receptors suggests a relatively eater limbic striatal effect of CLZ compared to HAL.…”

Correlation of 125I‐LSD autoradiographic labeling with serotonin voltage clamp responses in Aplysia neurons

“…Detection of serotonin receptors has been greatly facilitated by the develo ment of the high specific activity radioligand lZ51-L8D (Engel et al, 1984;Kadan et al, 1984). The high energy emissions of the '251-isotope make this compound especially useful for autoradiographic studies (Altar et al, 1986;Hartig, 1988. Yagaloff andHartig, 1985).…”