10years of MS instrumental developments – Impact on LC–MS/MS in clinical chemistry

Gas chromatography coupled to atmospheric pressure ionization mass spectrometry (GC-API-MS): Review

“…The ionization mechanisms occurring in atmospheric pressure ionization (API) sources are of low-energy (soft), which generate spectral data typically rich in molecular or protonated molecule information. Ionization in LC/MS can be realized by electrospray ionization (ESI) [5], atmospheric pressure chemical ionization (APCI) [6] , photo ionization (APPI) [7,8], atmospheric pressure laser ionization (APLI) [9,10] and others [11,12]. In GC-MS and LC-MS different instruments are used, since in GC-MS compounds are ionized at vacuum (EI and CI) and in LC/MS at atmospheric pressure [13].…”

Tissue distribution of pretomanid in rat brain via mass spectrometry imaging

“…Quantification of drugs in tissue homogenates is now mostly accomplished with liquid chromatography-mass spectrometry (LC-MS/MS) methods (Himmelsbach, 2012), within which spatial information is totally lost. The need to identify the main cell target of antitubacular drugs and molecular interaction after such adminstration is of high importance (Dartois, 2014).…”

Comparison of the quantitative performance of a Q‐Exactive high‐resolution mass spectrometer with that of a triple quadrupole tandem mass spectrometer for the analysis of illicit drugs in wastewater

“…A significant disadvantage of using triple quadrupoles for detection purposes is their inability to detect non‐target compounds, as the analysis methodology should be optimized regarding the m/z values of precursor and product ions, as well as the collision energy and electrospray ionization source conditions. Thus, high‐resolution mass spectrometry (HRMS) is becoming widespread for the analysis of illicit drugs . Advanced HRMS instruments combine crucial features such as improved selectivity and improved mass resolution, lower cost, and relatively easy maintenance.…”