Comparison of the quantitative performance of a Q‐Exactive high‐resolution mass spectrometer with that of a triple quadrupole tandem mass spectrometer for the analysis of illicit drugs in wastewater

Abstract

The Q-Exactive mass spectrometer proved to be suitable for trace detection and quantification of most of the tested drugs in wastewater, with performance comparable to that of the commonly used MS/MS triple quadrupole, but with better selectivity.

Development of a sensitive, accurate and robust liquid chromatography/mass spectrometric method for profiling of angiotensin peptides in plasma and its application for atherosclerotic mice

“…Despite the uniqueness of such a solution, HRFS still suffers from false positive results (data not shown). Such conclusions are in good agreement with previous data [17,19,20]. As described previously [17,20], HRFS MS is also not equally matrixtolerant as quadrupole-based MS/MS.…”

“…Such conclusions are in good agreement with previous data [17,19,20]. As described previously [17,20], HRFS MS is also not equally matrixtolerant as quadrupole-based MS/MS. Some limitation may be insufficient specificity of the tested high-resolution instrument.…”

“…Some limitation may be insufficient specificity of the tested high-resolution instrument. Other authors have demonstrated that the latest generations of HR instruments with improved resolution (up to 100,000 at 400 m/z) and stability of accurate mass measurements can produce an equal or superior selectivity compared with unit mass resolution MS/MS [20]. In the present study, however, the best sensitivity and precision were achieved with the use of third LC/MS configuration and the method based on this set-up was used for further studies.…”

National monitoring of nicotine use in Czech and Slovak Republic based on wastewater analysis

“…The pooled water samples were analyzed in triplicate. The extraction and analysis were performed in one step using in line SPE liquid chromatography coupled with a hybrid mass spectrometer (MS) Q-Exactive (quadrupole coupled to high resolution orbital trap MS, Thermo Scientific) as it is described previously (Fedorova et al 2013). Isotope dilution and internal standard method together with matrixmatched standards were used to eliminate matrix effects.…”

Target and Non-target Techniques for the Quantitation of Drugs of Abuse, Identification of Transformation Products, and Characterization of Contaminants of Emergent Concern by High Resolution Mass Spectrometry

“…Nowadays, highresolution instruments such as the quadrupole time of flight (Q-TOF) or the Orbitrap are routinely used in urine analysis as screening tools for doping (Li et al 2013;Musenga and Cowan 2013;Sundström et al 2013). However, few methods have been implemented for the analysis of illicit drugs in wastewaters Fedorova et al 2013) despite clear advantages offered by full-scan HRMS such as enabling the screening of previously-acquired data for drugs of abuse that are identified after initial data processing has occurred.…”