Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Cabar, Fábio Roberto; Teshima, Décio Roberto Kamio; Pereira, Pedro Paulo; Antonângelo, Leila; Schultz, Regina; Francisco, Rossana Pulcineli Vieira

doi:10.6061/clinics/2016(12)04

Cited by 4 publications

(3 citation statements)

References 22 publications

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“…These result also show agreement with Zou et al [21] study which published in 2013 showed that Individual measurements of serum VEGF levels is strongly related to early pregnancy outcomes for women with IUP and EP, and pregnancy associated VEGF level provide diagnostic accuracy for the presence of tubal EP. Furthermore, , Cabar et al [22] study which conducted in 2013 in Brazil and included 34 patients with an ampullary ectopic pregnancy showed an increase in the depth of trophoblastic penetration into the tubal wall associated with increasing maternal serum VEGF concentration. Flora Saghafi et al [23] 98 Kirkuk Journal of Medical Sciences -Volume 10/ Issue 2/ 2022 study also showed agreement with present study which found serum VEGF levels could be of great help in differentiating tubal pregnancy from normal pregnancy with appropriate sensitivity and specificity.…”

Section: Resultsmentioning

confidence: 97%

Evaluation of Serum Vascular Endothelial Growth Factor in Ectopic Pregnancy

Yuldurum¹,

Amin²

2022

KJMS

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 Background: Ectopic pregnancy is a common life threatening complication of early pregnancy refers to a gestation in which the fertilized ovum implants on any tissue other than the endometrial membrane lining the uterine cavity. Vascular endothelial growth factor (VEGF) is an angiogenic factor and plays a key role in the establishment of a viable pregnancy, participating in the processes of implantation and placentation, and appears to be significantly increased in early pregnancy complications.  Aim of study:To determine serum level of vascular endothelial growth factor (VEGF) and evaluate their capacity to serve as a marker for diagnosis of ectopic pregnancy. Methods: A case-control study that was conducted in the Department of Obstetrics and Gynecology at Azadi Teaching Hospital/Kirkuk-Iraq, during the period of nine months from the 1 st of February 2021 until 30 th of October 2021.The statistical analysis included 90 women with early pregnancy at 6 weeks of gestation who attended obstetrical emergency unit and outpatient clinic. They were divided into three groups included 30 cases in each group. Group one diagnosed as ectopic pregnancy, group two diagnosed as arrested intrauterine pregnancy and group three as normal intrauterine pregnancy. They are diagnosed based on combination of their last menstrual period, transvaginal ultrasound, serum beta human chorionic gonadotropin (BhCG) results, and histopathologically proved for ectopic pregnancy.After verbal consent Serum vascular endothelial growth factor (VEGF) was measured by a kit uses enzyme linked immune sorbent assay (ELISA) for all study participants. Result: There were no statistically significant difference between the study groups in age, body mass index and parity. There was significant higher mean of vascular endothelial growth among ectopic pregnancy in comparison to arrested intrauterine pregnancy and normal intrauterine pregnancy. When cut-off concentrations ≥200 pg/ml for vascular endothelial growth factor VEGF were used and correlated it with beta human chorionic gonadotropin BhCG showed that it could distinguish intrauterine pregnancy IUP from Ectopic pregnancy with %98 sensitivity and 96.3% specificity. Conclusion: Vascular endothelial growth factor VEGF is a potential marker for Ectopic pregnancy, its concentrations in ectopic pregnancy are higher than in those with normal and arrested IUP.

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Section: Resultsmentioning

confidence: 97%

Evaluation of Serum Vascular Endothelial Growth Factor in Ectopic Pregnancy

Yuldurum¹,

Amin²

2022

KJMS

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“…In the analysis, the authors of this work used term of sensitivity and specificity and not on a quantitative level, but on a qualitative one [8]. In work Cabar F. R. et al the relationship between the depth of trophoblastic infiltration, divided into stages, and the concentration of serum vascular endothelial growth factor in patients with an ampullary ectopic pregnancy, was determined [9]. On the basis of the ROC curves, the boundary values of this endothelial growth factor were determined and then, using parameters sensitivity and specificity, they evaluated the effectiveness of isolating stage III from the first and second for this factor, namely, the concentration of endothelial growth factor.…”

Section: Evaluation Of the Effectiveness Of Various Methods Of Diagnomentioning

confidence: 99%

About the Evaluation of the Effectiveness of Various Methods of Diagnosis, Prediction and Classification Presented in the Literature

Petrenko¹

2019

IJDSA

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The literature presents a large number of very different ways to diagnose, predict and classify. In support of their usefulness and effectiveness, various parameters are often used, from a large number of them, which are not always necessary and sufficient, since they do not unequivocally characterize efficiency. The purpose of this work was to build a theory in which the characteristic parameters would be clearly defined, necessary and sufficient to identify and evaluate the effectiveness of the method itself and the databases to which this method was applied. On the basis of an objective analysis of all known parameters characterizing the effectiveness of various methods of diagnosing and predicting, necessary and sufficient conditions were determined for them that ensure the unambiguity of the conducted assessments of their effectiveness. Some examples have shown their effectiveness. Full unambiguity and certainty in the reflection of the effectiveness of any method of diagnosis and prediction is achieved only when all the parameters characterizing it are interconnected by one equation. The paper presents a set of such equations, from which it follows that the uniqueness of the evaluation of the effectiveness of any method is achieved only when it is reflected by a triad of characteristic basis parameters. Only such a triad of efficiency parameters, interconnected by characteristic equations obtained in theory, that is, in a deterministic way, can one achieve an unambiguous estimate of efficiency and its interpretation. It is important that the parameters characterizing the data arrays for which one or another method is tested can also act as basic parameters. On the basis of the equations obtained in the work, by means of the triad of basic parameters, all other parameters are determined, diversifying the efficiency. One of these triads includes sensitivity, specificity and accuracy, which in this combination uniquely determine efficiency. In this paper, from these positions, data of some works of recent years are analyzed.

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“…59 Furthermore, the depth of trophoblast penetration into the tubal wall is negatively associated with the concentration of serum VEGF. 60 VEGF and its receptors (VEGFRs) were expressed in all sections of the Fallopian tubes, including the fimbria, ampulla, and isthmus. VEGF and VEGFRs were downregulated in the Fallopian tubes with tubal pregnancy compared with the normal Fallopian tubes of pseudo-pregnant women.…”

Section: The Invasion Stage Of Tubal Implantationmentioning

confidence: 99%

Interaction networks between the Fallopian tubes and the embryo in human tubal pregnancy: Current knowledge and perspectives

Jiang

Jian-xiong

2021

J of Obstet and Gynaecol

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Aim: More than 90% of ectopic pregnancies occur in the Fallopian tubes. As the pathogenesis of tubal pregnancy remains largely unclear, the development of strategies to prevent and treat tubal pregnancy still represents a major clinical challenge. This review thoroughly summarizes the current data, aiming to determine the genes and signaling pathways that are involved in the pathophysiology of human tubal pregnancy. Methods: An electronic search from databases of PubMed, Google Scholar, and Chinese databases was carried out using key words pertaining to the pathogenesis of tubal pregnancy from the perspectives of both the Fallopian tubes and the embryo. A review of the literatures including review articles, experimental, and observational studies and case reports published between 1999 and 2021 was conducted. Results: Tubal pregnancy results from the interaction networks between the Fallopian tube and the embryo rather than from simple tubal abnormality. Furthermore, the embryo-maternal communication is supposed to start from the preimplantation period to the implantation period. Conclusion: A greater understanding of the interaction networks between the Fallopian tubes and the embryo is of great significance for the prevention and medical treatment of tubal pregnancy.

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Serum concentration of vascular endothelial growth factor and depth of trophoblastic invasion in ampullary ectopic pregnancy

Cited by 4 publications

References 22 publications

Evaluation of Serum Vascular Endothelial Growth Factor in Ectopic Pregnancy

Evaluation of Serum Vascular Endothelial Growth Factor in Ectopic Pregnancy

About the Evaluation of the Effectiveness of Various Methods of Diagnosis, Prediction and Classification Presented in the Literature

Interaction networks between the Fallopian tubes and the embryo in human tubal pregnancy: Current knowledge and perspectives

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