Protective effects of Tualang honey on bone structure in experimental postmenopausal rats

Zaid, Siti Sarah Mohamad; Sulaiman, Siti Amrah; Othman, Nor Hayati; Ima‐Nirwana, Soelaiman; Shuid, Ahmad Nazrun; Mohamad, Norazlina; Muhamad, Norliza

doi:10.6061/clinics/2012(07)13

Cited by 32 publications

(41 citation statements)

References 32 publications

(33 reference statements)

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“…In addition, Hussain et al [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.Tualang honey is a wild, multi floral honey produced by Apis dorsata bees that form hives on the branches of giant trees named Tualang in the Malaysian rainforest, and it has been reported recently that ovariectomized rats that received Tualang honey showed greater improvements in trabecular bone structure than rats receiving calcium [12], implying the beneficial effects of Tualang honey supplementation on bone. Nevertheless to date, administration of Tualang honey in combination with exercise on bone health and antioxidant status in rats has not been investigated, thus the present study was proposed.…”

mentioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

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Open Access Research Articleactivity is through modification in bone turnover which occurs through two fundamentally different processes, i.e. modeling and remodeling with the activities of osteoblast and osteoclast cells in the mechanisms of bone formation and bone resorption [3]. A number of biochemical assays have been described for measuring serum and urinary concentration of markers of bone metabolism [4] that allow a good estimation of bone metabolic processes and have been established as useful parameters in assessing changes in bone turnover. To date, the mechanisms by which combined exercise and dietary intake lead to changes in bone metabolism are not fully understood.Nutritional supplementation is another main factor associated with bone health and development. Aoe et al. [5] reported that as compared to drugs that have a rapid effect, administration of nutrients related to bone metabolism is relatively safe and inexpensive. To date, the effects of different types of supplementation such as calcium, vitamin D, milk, soy and soy protein on bone mass, turnover and mineral density have been reported [6][7][8][9]. One of the nutrients that has long tradition of use within various medical systems and prescribed for variety of uses from ancient time is honey. Ariefdjohan et al. [10] reported that honey has the potential to increase calcium absorption after 2 days of acute feeding in rats. In addition, Hussain et al. [11] reported that honey has similar effects with hormone replacement therapy on bone densitometry in postmenopausal women. Therefore, it was hypothesized that honey may play a role in increasing bone health.Tualang honey is a wild, multi floral honey produced by Apis dorsata bees that form hives on the branches of giant trees named Tualang in the Malaysian rainforest, and it has been reported recently that ovariectomized rats that received Tualang honey showed greater improvements in trabecular bone structure than rats receiving calcium [12], implying the beneficial effects of Tualang honey supplementation on bone. Nevertheless to date, administration of Tualang honey in combination with exercise on bone health and antioxidant status in rats has not been investigated, thus the present study was proposed. AbstractPurpose: To investigate the effects of combined jumping exercise and honey supplementation on bone metabolism and antioxidant status in female rats.

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mentioning

confidence: 99%

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Tavafzadeh¹,

Ooi

Chen³

et al. 2015

JESO

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“…Previous studies showed that tualang honey improved the trabecular structure of bone in OVX rats [4,5] . We used MHCP in this study, and the 5% honey diet tended to decrease (p=0.06) and the 10% honey diet significantly decreased serum CTx concentration in OVX mice without a change in uterine weight.…”

Section: Discussionmentioning

confidence: 89%

“…In addition, honey improved the trabecular structure of bone as assessed using histomorphometry in OVX rats that were orally gavaged daily for 6 weeks [5] . Thus, honey may prevent bone loss due to menopause.…”

Section: Introductionmentioning

confidence: 99%

“…It was reported that manuka honey had a potent inhibitory activity against the influenza virus [10] . However, there had been few studies regarding the effects of manuka honey on bone metabolism and gut microflora, whereas some studies were conducted by using other species of honey as stated above [4][5][6] . Therefore, this study investigated the effects of MHCP on bone metabolism and caecal bacterial contents in OVX mice.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Manuka Honey Combined with α-Cyclodextrin on Bone Metabolism and Caecal Bacterial Contents in Ovariectomized Mice

Kruger¹

2015

IJFNS

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Honey has antimicrobial, antitumor, antioxidant, and anti-inflammatory effects. However, there have been few studies regarding the effects of manuka honey on bone metabolism and gut microflora. This study investigated the effects of manuka honey combined with α-cyclodextrin, Manuka Honey with Cyclopower TM (MHCP) on bone metabolism and caecal bacterial contents in ovariectomized (OVX) mice. Seven-week-old female Balb/c-strain mice were divided into four groups: sham-operated (sham) group, OVX group, and OVX mice that were fed a diet containing 5% or 10% (w/w) MHCP. After 9 weeks, the mice were sacrificed, and serum, uterus, caecum, and femur samples were obtained. Successful removal of the ovaries and induction of the osteoporotic process in OVX mice were demonstrated by a significant decrease in uterine weight and a significant increase in receptor activator of NF-κB ligand (RANKL) mRNA expression of the femur, compared to sham, respectively. Compared to the OVX group, MHCP reduced serum C-terminal telopeptide of type Ι collagen concentration as well as RANKL and nuclear factor of activated T-cells c1 (NFATc1) mRNA expression of the femur. Furthermore, MHCP increased caecal bifidobacteria and bacteroides contents. These results suggest that the MHCP expressed prebiotic effects, which might reduce bone resorption in OVX mice.

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“…26 Oral consumption of honey could improve bone structure in osteoporotic rats. 27,28 In a recent review, it was demonstrated that honey could prevent cancerogenesis through alteration of cell cycle molecular processes 19 and some studies reviewed the effectiveness of honey for wound healing. 18,29,30 Although several studies demonstrated the soft tissue wound healing effect of honey, 18,23,29,30 its effect on bone defects has not been evaluated.…”

Section: 5005/jp-journals-10024-2210mentioning

confidence: 99%

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

Hajizadeh

Derakhshan

Peimani

et al. 2018

The Journal of Contemporary Dental Practice

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Aim: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancerogenic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. Materials and methods:This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05).Results: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). Effect of Topical Honey on Mandibular Bone Conclusion:The results showed that honey could accentuate bone healing of mandibular small defects in rats.Clinical significance: Honey might have potential in repair of human alveolar bone defects.

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Protective effects of Tualang honey on bone structure in experimental postmenopausal rats

Cited by 32 publications

References 32 publications

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Changes in Bone Metabolism and Antioxidant Status with Combined Exercise and Honey Supplementation in Young Female Rats

Effects of Manuka Honey Combined with α-Cyclodextrin on Bone Metabolism and Caecal Bacterial Contents in Ovariectomized Mice

Effect of Topical Honey on Mandibular Bone Defect Healing in Rats

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