Aim: In medicine, honey is known for its various biological or pharmacological effects, from wound dressing to anticancerogenic and from anti-inflammatory to antibacterial activities. The aim of the current study was to evaluate the effect of honey on healing of mandibular bone defects in a rat model. Materials and methods:This animal study was performed on 24 wild-type Wistar rats. Following shaving, disinfection, and extraoral incision, a 2 × 2 mm defect was created at mandibular angle. In the experimental group, the defect was filled with sterile honey, while it was left unfilled in the control group. The rats were sacrificed after 2 and 4 weeks and defects were assessed histologically. The results were compared using Mann-Whitney U-test (α = 0.05).Results: After 2 weeks, five samples of the experimental group were in mineralization phase, while all samples of the control group were in the vascularization phase (p = 0.015). After 4 weeks, the defects were filled in four samples of the experimental group, while all samples of the control group were in the mineralization stage (p = 0.002). Histomorphometric assessment revealed that the mean new bone formation in the experimental group was significantly more than the control group, both after 2 and 4 weeks (p = 0.041). Effect of Topical Honey on Mandibular Bone Conclusion:The results showed that honey could accentuate bone healing of mandibular small defects in rats.Clinical significance: Honey might have potential in repair of human alveolar bone defects.
Objective: Regeneration of maxillofacial bone defects is clinically challenging. It is believed that Manuka honey can enhance wound healing and decrease inflammation. This study sought to assess the efficacy of Manuka honey for the regeneration of critical size calvarial bone defects in rats. Methods: This study was conducted on 36 adult male Wistar rats in two groups of 18. Bone defects measuring 8mm in diameter were created in the parietal bone at the sagittal suture. In the test group, defects were filled with Manuka honey while defects remained empty in the control group. Six animals were sacrificed in each group at four, eight, and 12 weeks post-operation for histological and histomorphometric analyses of tissues. The data were analyzed using two-way ANOVA, Independent ttest, and one-way ANOVA (P< 0.05). Results: No significant difference was noted in bone formation between the test and control groups at four weeks (P=0.53) but the amount of newly formed bone in the test group was higher than that in the control group at eight (P=0.004) and 12 (P< 0.001) weeks. The amount of newly formed bone in the control group was not significantly different at four, eight, and 12 weeks (P=0.54) while the corresponding values were significantly different in the test group (P< 0.001). No inflammation was noted in any group. Conclusion:Local application of Manuka honey may enhance the regeneration of critical size calvarial bone defects in rats.
Introduction: Bilateral sagittal split osteotomy (BSSO) is a technique commonly used to correct mandibular disproportions, while neurosensory disorders are common following this technique. Low-level laser irradiation has shown promising results to relieve the neurosensory disorders of BSSO technique. Objective:The aim of this study was to compare the effects of low-level laser irradiation on the neurosensory complications related to the BSSO technique. Materials and methods:In this prospective, double-blinded clinical trial, 13 patients candidate for BSSO surgery were selected and went under complete clinical neurosensory tests (CNTs) including brush stroke discrimination; two-point discrimination; and contact, thermal, and pinprick discrimination, as well as visual analog scale (VAS) assessments. The laser GaAlAs (820-830 µm wavelength) irradiation was done for total six sessions after surgery for the patients at one side accidentally, and the opposite site was a control by irradiation of placebo. The values of CNT assessments between the experimental and control sites were analyzed employing Wilcoxon signed-rank test.Results: Higher values of VAS and brush stroke discrimination test were observed in the laser-irradiated sites than in the control sites, although without any significant differences (p > 0.05). Moreover, significantly higher values of pinprick discrimination test were noted in the experimental sites on days 1, 2, 3, 4, 7, 14, 28, and 60 (p < 0.05). The thermal test results were higher in the study sides, and the differences of both sides were significant on days 2, 3, 4, 7, 14, and 28 (p < 0.05). Conclusion:In total, GaAlAs low-level laser irradiation after the BSSO surgery results in both subjective and objective improvements regarding the time and magnitude of return of function; however, in some tests no significant differences were found between laser-irradiated and control areas.
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