Elderly Hypertensives Show Decreased Cognitive Performance Compared with Elderly Normotensives

Matoso, J M D; Santos, Wellington Bruno; Moreira, Irene de Freitas Henriques; Lourenço, Roberto Alves; Correia, Marcelo

doi:10.5935/abc.20130080

Cited by 6 publications

(6 citation statements)

References 27 publications

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“…Several experiments are in line with the findings of the present study and have demonstrated a negative association between HTN status and high blood pressure values with poor cognitive performance in older adults [ 4 – 7 ]. In the experiment of Obisesan [ 6 ], for example, the authors investigated the association between HTN status and cognitive performance using data from the Third National Health and Nutrition Examination Survey (NHANES III).…”

Section: Discussionsupporting

confidence: 92%

“…As in the present study, results demonstrated that hypertensive patients showed a lower global cognitive score (i.e., MMSE) than normotensive patients. However, an increasing number of studies have extended these results and demonstrating that HTN is associated with a low functioning of numerous cognitive domains, such as executive function, praxis, learning, and memory [ 5 , 7 ].…”

Section: Discussionmentioning

confidence: 99%

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Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study

Coelho-Júnior

Gambassi

Irigoyen

et al. 2018

Journal of Aging Research

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The present study aimed to investigate whether sarcopenia interferes in the association between HTN and cognitive function in community-dwelling older women. One hundred and eleven older women were recruited and dichotomized in hypertensive (n=63) and normotensive groups (n=48). Volunteers underwent evaluations of the sarcopenic state (i.e., skeletal muscle mass, short physical performance battery (SPPB), balance), hemodynamic parameters, and global cognitive status (i.e., Mini-Mental State Examination (MMSE)). Data demonstrated that hypertensive patients had lower global cognitive status than normotensive subjects. When volunteers were divided according to sarcopenic status, data demonstrated that hypertensive patients with low performance on SPPB (0.006), low values of sarcopenic index (0.03), and low performance on sit-to-stand (0.09) demonstrated poor cognitive status compared with hypertensive patients with normal values of these variables. In conclusion, data of the current study indicate that the sarcopenic state might interfere in the association among hypertension and poor cognitive status, once a higher frequency of hypertensive patients with low lower limb muscle function (i.e., SPPB and sit-to-stand) and muscle mass index (i.e., Janssen index) was observed in the <24 MMSE segment, in comparison with hypertensive patients with normal results in these parameters.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study

Coelho-Júnior

Gambassi

Irigoyen

et al. 2018

Journal of Aging Research

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“…Particularly, many studies have demonstrated that hypertension could result in cognitive impairment [7–11, 28–31]. Goldstein et al [7] demonstrated that hypertension was associated with faster cognitive decline and a cognitive phenotype characterized by poorer attention and executive functioning and slower processing.…”

Section: Discussionmentioning

confidence: 99%

Impairment in Preattentive Processing among Patients with Hypertension Revealed by Visual Mismatch Negativity

Ren

Wang

et al. 2014

BioMed Research International

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Objective. Patients with hypertension show deficits in cognitive function. However, the neural mechanisms underlying the preattentive information processing in hypertensive patients are poorly understood. We seek to investigate whether hypertensive patients have impairments in preattentive information processing. Methods. We compared visual mismatch negativity (vMMN) between 15 hypertensive patients and 15 age-matched healthy controls, which was elicited by the change of visual duration randomly presented in both peripheral visual fields. In addition, the global cognitive function for all participants was assessed with Mini-Mental State Examination (MMSE). Results. The vMMN in deviant-standard comparison was observed at occipital-temporal regions. Compared with normal healthy controls, the amplitude of vMMN was significantly decreased in hypertensive patients (P < 0.05). Meanwhile, the vMMN peak latency was delayed in the hypertensive group (P < 0.05). However, the MMSE scores of patients with hypertension were not significantly different from those of controls (P > 0.05), and there was no significant correlation between the mean amplitude of vMMN and SBP, DBP, and MMSE in hypertensive individuals, respectively. Conclusions. These data indicate dysfunction of automatically change detection processing in patients with hypertension. Moreover, the changes of vMMN provide a more objective and reliable assessment for cognitive impairment in hypertensive patients.

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“…17 The applied tests, previously used by several authors, [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32] can reveal such minor alterations of the cognitive function, which are not necessarily evident during everyday activity. All tests were carried out and scored by a trained psychologist.…”

Section: Neuropsychological Examinationmentioning

confidence: 99%

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

Kovács

Bajkó²,

Szekeres³

et al. 2014

Journal of the American Society of Hypertension

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Hypertension and dyslipidemia belong to the most prevalent modifiable risk factors for cerebrovascular and cardiovascular diseases. Hereby, we aimed to examine the combined effects of newly diagnosed hypertension and hyperlipidemia on the characteristics of the arterial wall and on cognitive function. We examined 72 hypertensive and 85 apparently healthy individuals. Based on serum lipid levels, four subgroups were created ranging from normotensive-normolipidemic to hypertensivehyperlipidemic subjects. Carotid intima-media thickness (IMT), arterial stiffness, and cognitive function were assessed. IMT of controls was the lowest, whereas that of patients with both risk factors the highest. Stiffness parameters increased when both risk factors were present, whereas subjects with only one risk factor exhibited intermediate values. Hypertensive patients performed worse when memory, attention, reaction time, and trait anxiety were assessed. Significant worsening of IMT, arterial stiffness, and sum of neuropsychological scores was observed along with increasing mean arterial pressure. Generally, hyperlipidemia combining with hypertension resulted in further worsening of all examined parameters. Subclinical changes of the vascular wall and cognitive performance are already present in recently diagnosed hypertensive patients. Combination of hyperlipidemia and hypertension results in more severe impairments, therefore, early and intensive treatment may be crucial to prevent further deterioration. J Am Soc Hypertens 2014;-(-):1-11.

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Elderly Hypertensives Show Decreased Cognitive Performance Compared with Elderly Normotensives

Abstract: Cognitive performance is lower in elderly hypertensives as compared with elderly normotensives.

Cited by 6 publications

References 27 publications

Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study

Hypertension, Sarcopenia, and Global Cognitive Function in Community-Dwelling Older Women: A Preliminary Study

Impairment in Preattentive Processing among Patients with Hypertension Revealed by Visual Mismatch Negativity

Elevated LDL-C combined with hypertension worsens subclinical vascular impairment and cognitive function

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