Prognostic value of regional metastasis in squamous cell carcinoma of the tongue and floor of mouth

Amar, Ali; Rapoport, Abrão; Curioni, Otávio Alberto; Dedivitis, Rogério Aparecido; Cernea, Cláudio Roberto; Brandão, Lenine Garcia

doi:10.5935/1808-8694.20130134

Cited by 15 publications

(14 citation statements)

References 9 publications

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“…Statistically, oral squamous cell carcinoma (OSCC) is the most common HNSCC and accounts for 2-3% for all malignant tumors. Tongue squamous cell carcinoma (TSCC) is the most common carcinoma among OSCC cases, accounting for 25-40% of mouth neoplasms (1). The incidence of TSCC has increased in recent years, making it a major public health concern.…”

Section: Introductionmentioning

confidence: 99%

Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma

Liu

Shen

et al. 2014

Oncology Reports

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The aim of the present study was to investigate the expression and function of metastasis-associated in colon cancer 1 (MACC1) in tongue squamous cell carcinoma (TSCC) and its relationship with the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) (CD147). Levels of MACC1 and EMMPRIN expression were analyzed in 65 paraffin‑embedded tissue specimens of TSCC and in the adjacent non-cancerous tissues using immunohistochemistry (IHC). MACC1 expression was highly associated with lymphatic metastasis and EMMPRIN expression. Overexpression of MACC1 was significantly correlated with poor overall patient survival. A small interfering RNA (siRNA) was delivered into TSCCA cells to downregulate MACC1 expression. The CCK-8 assay showed that TSCCA cell proliferation was markedly reduced and that cisplatin resistance was attenuated. The suppression of MACC1 promoted the apoptosis of the TSCCA cell line. A Transwell experiment demonstrated that the migration and invasion abilities of the TSCCA cells were extremely downregulated. An ELISA experiment and western blotting revealed that the secretion of urokinase-type plasminogen activator system (uPA) in the supernatant of the culture medium and uPA expression were significantly reduced. Experiments revealed that the secretion of metalloproteinase 2 (MMP2) in the supernatant of the culture medium and MMP2 expression were not affected. MACC1 may serve as a novel biomarker and therapeutic target for TSCC.

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Section: Introductionmentioning

confidence: 99%

Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma

Liu

Shen

et al. 2014

Oncology Reports

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“…O reconhecimento precoce das lesões malignas é importante na melhoria do prognóstico, desenvolvendo notáveis probabilidades de cura e expandindo a qualidade de vida dos pacientes acometidos pela doença, já que essa neoplasia interfere diretamente na funcionalidade do indivíduo e reflete nos índices de sobrevida 16,17 .…”

Section: Revisão De Literaturaunclassified

Conhecimento dos Cirurgiões-Dentistas da rede pública sobre câncer bucal: Revisão de literatura

et al. 2018

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O câncer bucal é apontado como um problema de saúde pública, considerado potencialmente fatal, com elevada incidência global. Considerando a importância da prevenção e do diagnóstico precoce da neoplasia, a atenção primária à saúde é uma ambiência adequada para o desenvolvimento dessas ações, e a atenção odontológica exerce papel estratégico nesse enfrentamento. O objetivo desse trabalho é averiguar, por meio de uma revisão de literatura, o nível de conhecimento dos cirurgiões-dentistas sobre o diagnóstico do câncer bucal e sua prevenção. O papel do cirurgião-dentista é de extrema importância nos diversos níveis de atenção a saúde, além de ser responsável também pela articulação e criação de práticas e políticas que diminuam a exposição aos fatores de risco e introduzam na população uma consciência quanto à importância da prevenção e do diagnóstico precoce do câncer.

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“…The main prognostic factor for HNSCC is lymph node metastasis, decreasing by 50% patient survival chances. [ 4 , 5 ]. Presence of tumor hypoxia is another important prognostic factor [ 6 ]…”

Section: Introductionmentioning

confidence: 99%

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

et al. 2018

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AimsJumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types.Methods and resultsWe aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk.ConclusionJMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets.

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Prognostic value of regional metastasis in squamous cell carcinoma of the tongue and floor of mouth

Abstract: Salvage procedure success and survival rates are lower for pN+ patients; pN+ individuals also have more relapsing local disease.

Cited by 15 publications

References 9 publications

Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma

Downregulation of MACC1 inhibits invasion, migration and proliferation, attenuates cisplatin resistance and induces apoptosis in tongue squamous cell carcinoma

Conhecimento dos Cirurgiões-Dentistas da rede pública sobre câncer bucal: Revisão de literatura

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

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