Thyroid papillary carcinoma associated to Hashimoto's thyroiditis

Campos, Luiz Alexandre Albuquerque Freixo; Picado, Sílvia Miguéis; Guimarães, André Vicente; Ribeiro, Daniel Araki; Dedivitis, Rogério Aparecido

doi:10.5935/1808-8694.20120037

Cited by 31 publications

(26 citation statements)

References 23 publications

(38 reference statements)

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“…A follicular neoplasm was found in 2 cases, which were later diagnosed as PTC with tissue biopsy. Campos et al [29] have stated that nodule size is not related to PTC development in patients with HT. Although due to the low number of patients with malignancy it is not possible to debate statistical significance in our study, we believe that characteristics indicating malignancy such as microcalcification on nodule ultrasonography are more important than nodule diameter for thyroid nodules developing on an HT background.…”

Section: Discussionmentioning

confidence: 99%

Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study

Keskin¹,

Savaş‐Erdeve²,

Aycan³

2016

Horm Res Paediatr

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Background: Currently, there is an inadequate number of studies on nodule and malignancy development in children and adolescents with Hashimoto thyroiditis (HT). Material and Methods: Patients who were diagnosed with HT between 2004 and 2013 were included in the study. The HT diagnosis was made with a heterogeneous appearance on thyroid ultrasonography and the elevation of antithyroid peroxidase and/or anti-thyroglobulin antibodies. Fine-needle aspiration biopsy (FNAB) was performed in cases with a nodule size >1 cm or who had ultrasonography findings indicating malignancy. Results: A total of 39 (13%) thyroid nodules were detected in 300 patients with a diagnosis of HT. Papillary thyroid carcinoma (PTC) was diagnosed in 2 of the 12 cases in whom FNAB was performed. The thyroid nodule was detected at the same time as HT in the 2 cases with malignancy. The PTC diagnosis was made 2 years after the HT diagnosis in the first case and 3 years later in the second case. The largest diameter of the thyroid nodule was 5 mm in both cases. Conclusion: The thyroid nodule rate on an HT background was found to be 13%, and the thyroid malignancy rate was 0.67% in our study.

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Section: Discussionmentioning

confidence: 99%

Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study

Keskin¹,

Savaş‐Erdeve²,

Aycan³

2016

Horm Res Paediatr

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“…The percentage of coexistence of these two diseases in the histopathological material of thyroidectomised patients varies from 8.6 to 39%. [5,9,10,11,16,17,18,19,20] Two meta-analyses report a percentage of approximately 27% [2,12]. The varying incidence rates of PTC in HT may be due to several factors such as different diagnostic criteria for HT, various surgical procedures and heterogeneous patient characteristics [1].…”

Section: Ethical Approval -Informed Consentmentioning

confidence: 97%

“…In this study, the observation was based on the hypothesis of correlation of PTC with HT. [2] Up to now, there is controversy in the literature regarding the association between PTC and HT [1,2,5,6,[9][10][11][12][13][14][15].…”

Section: Ethical Approval -Informed Consentmentioning

confidence: 99%

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Papillary thyroid carcinoma in Hashimoto’s thyroiditis as an incidental finding

et al. 2016

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Background:The association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC), although documented worldwide, still remains a subject of debate among scientists. The aim of this study is to investigate the incidence of papillary thyroid carcinoma in Hashimoto's thyroiditis as an incidental finding based on the histopathological specimens of patients submitted to total thyroidectomy for benign conditions of the thyroid gland.

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“…Campos LAAF, et al, 13 studied three hundred and fifteen thyroidectomies, of which forty one were papillary carcinomas and forty five were nodular goitres. Of the remaining two hundred twenty nine cases, chronic thyroiditis was reported in 12.25% cases.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Neoplasms and Peritumoral Morphology in Thyroidectomy Specimens

Padmavathi¹,

Raj²

2015

jemds

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Thyroid neoplasms represent the most common malignancies of the endocrine system. They are known to occur in association with benign lesions of the thyroid, like multinodular goitre and Hashimoto thyroiditis. AIMS AND OBJECTIVES: To study the neoplasms of thyroid and their peritumoral morphology. MATERIALS AND METHODS: All thyroidectomy specimens received in the Department of Pathology, RRMCH over a period of three years from June 2011 to May 2014 were included in the study. Thyroidectomies for non-neoplastic lesions were also extensively sampled and morphologically studied, with focus on peritumoral morphology, in neoplasms. RESULTS: Of the one hundred and fifty four thyroidectomy specimens received over three years, one hundred and thirteen (73.4%) were non-neoplastic, and forty one were neoplastic (26.6%). Colloid goitre and lymphocytic infiltrate were the most common features in the peritumoral thyroid tissue, followed by multinodular goitre. Hashimoto thyroiditis and Hurthle cell change were noted in 11.5% of cases. Tumors were multicentric in 11.5% of cases. Malignancy was detected in eight of the fifty nine thyroidectomies performed for multinodular goitre. Of the thirty four surgeries for Hashimoto thyroiditis, four were reported as malignant on histopathology. CONCLUSION: All thyroidectomies, including those operated for benign lesions, need to be extensively sampled and morphology studied due to the possibility of occult malignancy. Larger series need to be studied to find a causal association between the two.

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Thyroid papillary carcinoma associated to Hashimoto's thyroiditis

Abstract: There is a rate of 26.8% of patients with association between TH and CPT, but without differences in relation to tumor size.

Cited by 31 publications

References 23 publications

Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study

Co-Existence of Thyroid Nodule and Thyroid Cancer in Children and Adolescents with Hashimoto Thyroiditis: A Single-Center Study

Papillary thyroid carcinoma in Hashimoto’s thyroiditis as an incidental finding

Thyroid Neoplasms and Peritumoral Morphology in Thyroidectomy Specimens

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