Oxidative, inflammatory and cardiometabolic biomarkers of clinical relevance in
            patients with metabolic syndrome

Chielle, Eduardo Ottobelli; Gens, Fagner; Rossi, Eliandra Mirlei

doi:10.5935/1676-2444.20180037

Cited by 4 publications

(7 citation statements)

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“…C reactive protein (CRP) is a protein of the pentraxin family, synthesized and released by endothelial cells in atherosclerotic plaques, hepatocytes, lymphocytes and macrophages, mainly in response to the increase of interleukin 7 (IL 7). It has been evidenced that US CRP in plasma is a biomarker of the inflammatory system in downstream MetS, and potentially a good biomarker for monitoring treatment results [ 12 , 38 , 39 ].…”

Section: Resultsmentioning

confidence: 99%

“…Redox homeostasis is maintained in physiological situations at the expense of the antioxidant regulation of the concentrations of oxidant species, and in terms of molecular biology it involves intracellular protein signaling and transcription mechanisms [ 11 ]. When these mechanisms are altered or absent, an excessive accumulation of biomarkers of inflammation and oxidative stress occurs, with byproducts of biomolecular oxidation, and signaling pathways are therefore altered [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

et al. 2020

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Metabolic Syndrome (MetS) is increasing worldwide regardless of culture, genetic, gender, and geographic differences. While multiple individual risk factors, such as obesity, hypertension, diabetes, and hyperlipidemia, can cause cardiovascular disease (CVD), it is the intercurrence of these risk factors that defines MetS as a cluster that creates an environment for atherosclerosis and other manifestations of CVD. Despite the advances in the knowledge and management of each of the components of MetS, there are two molecular biology processes, chronic inflammation and oxidative stress, which are still underdiagnosed and undertreated. In order to assess the effect of a dietary supplement on chronic inflammation in MetS, we conducted a clinical trial with volunteers receiving a formula composed of resveratrol, piperine and alpha tocopherol (FRAMINTROL®), together with their habitual treatment, for three months. The inflammatory state was evaluated by ultrasensitive C reactive protein (US CRP) and ferritin in plasma, and oxygen consumption and chemiluminescence in neutrophils. The results showed that ferritin decreased by 10% (p < 0.05), US-CRP by 33% (p < 0.0001), oxygen consumption by 55% (p < 0.0001), and spontaneous chemiluminiscence was by 25% (p < 0.005) after treatment. As far as we know, this is the first study showing a chronic inflammation decrease in MetS patients due to the administration of a biopower Resveratrol-piperine and alpha tocopherol dietary supplement together with conventional therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

et al. 2020

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“…Another cross-sectional study by Chielle et al (2018) recruited 85 Brazilian adults (36 MetS subjects and 48 healthy volunteers) aged 22 - 85 years from January to May 2017. The MetS group had a significant decrease in vitamin C concentration when compared to the group without MetS 43 . Comparative results were obtained from case-control studies assessing the relationship between plasma vitamin C status and MetS components.…”

Section: Introductionmentioning

confidence: 83%

“…Several oxidative markers were evaluated in Brazilian adult with and without MetS. The MetS subjects presented the increases in GGT, glutamic-pyruvic transaminase (GPT), glutamic-oxaloacetic transaminase (GOT), total ferric antioxidant power (FRAP), sulfhydryl groups (SH) and thiobarbituric acid reactive substances (TBARS) [43]. By contrasting the oxidative stress indicators and anti-oxidative capacity in healthy controls, the MDA level was higher whereas the levels of SOD and total antioxidant activity were lower in PCOS subjects with MetS [48].…”

Section: The Potential Mechanism Of Action For Vitamin C In the Managmentioning

confidence: 99%

“…In the United States population, vitamin C concentration correlate negatively with the number of MetS indicators and CRP level [42]. It was also estimated that the level of IL-6 was increased in Brazilian adults with MetS [43]. For MetS patients provided with a balanced diet and 500 mL/day orange juice, higher vitamin C intake but lower CRP and high sensitivity C-reactive protein (hsCRP) levels were observed after three months of intervention [53].…”

Section: The Potential Mechanism Of Action For Vitamin C In the Managmentioning

confidence: 99%

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Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong

Chin

2020

Int. J. Med. Sci.

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Oxidative stress and inflammation are two interlinked events that exist simultaneously in metabolic syndrome (MetS) and its related complications. These pathophysiological processes can be easily triggered by each other. This review summarizes the current evidence from animal and human studies on the effects of vitamin C in managing MetS. In vivo studies showed promising effects of vitamin C, but most of the interventions used were in combination with other compounds. The direct effects of vitamin C remain to be elucidated. In humans, the current state of evidence revealed that lower vitamin C intake and circulating concentration were found in MetS subjects. A negative relationship was observed between vitamin C intake / concentration and the risk of MetS. Oral supplementation of vitamin C also improved MetS conditions. It has been postulated that the positive outcomes of vitamin C may be in part mediated through its anti-oxidative and anti-inflammatory properties. These observations suggest the importance of MetS patients to have an adequate intake of vitamin C through food, beverages or supplements in order to maintain its concentration in the systemic circulation and potentially reverse MetS.

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Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs

et al. 2022

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Oxidative, inflammatory and cardiometabolic biomarkers of clinical relevance in patients with metabolic syndrome

Cited by 4 publications

References 0 publications

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Supplementation with Resveratrol, Piperine and Alpha-Tocopherol Decreases Chronic Inflammation in a Cluster of Older Adults with Metabolic Syndrome

Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Myeloperoxidase enzyme and Ferric-reducing antioxidant power concentrations in lean and obese dogs

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