Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Wong, Sok Kuan; Chin, Kok‐Yong

doi:10.7150/ijms.47103

Cited by 52 publications

(40 citation statements)

References 84 publications

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“…A study showed that patients with recurrent infections had impaired Microbial deaths in the body so, with the supplementation of Vitamin C through diet or intravenously, resulted in the killing of infection and condition of the patients improved significantly 40, 41 . This supports the improvement in the condition of COVID-19 patients with Vitamin C supplementation 16 .…”

Section: Fig 5: Functions Of Vitamin C In Human Bodysupporting

confidence: 80%

“…Vitamin B9 is required for the survival of Foxp3 + Treg cells. Studies have shown that Vitamin B9 is responsible for increased levels of Foxp [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . Dietary vitamin B9 maintains Foxp3 + Treg cells in the small intestine, A study was carried out in mice, and it showed that Mice maintained with vitamin B9(-) diet showed less vitamin B9 in the small-intestinal wash than controls.…”

Section: Fig 7: Role Of Vitamin E In Infectious Diseases In Humansmentioning

confidence: 99%

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2020

IJPSR

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As humanity is progressing, many new borne infections are borne, and the stability and efficiency of the human body are being tested. Today the World is fighting with a deadly Novel infection named Corona Virus Disease. The aim of this systematic review is to find out the efficacy of Nutritional Interventions against the infections caused in the body due to pathogens. Further, the recommendations can be made for further researches based on the evidence collected. To collect the data, electronic databases such as Scopus, Pub Med, NCBI, and web of science have been used. The peer-reviewed journals and newspaper reports are being cited with the English language. The papers were published from 1989 to 2020. Finally, a total of twelve studies were identified, and the pathways of all nutrient metabolisms are included in the study. The studies were mostly carried out in Asian and European countries on human as well as animals. All the studies except one supported the role of Nutrients in preventing and curing the infection caused by pathogens such as Bacteria and Viruses. The Dietary Interventions in any form were proven to have a positive effect on strengthening the Immune system and also curing the disease. The results are supporting that Adaptive immunity can help a person to fight with COVID-19. Mostly the adaptive immunity is built by vaccinations or certain medications. But many researches showed that a diet filled with nutrients and the right choices of food can help to build adaptive immunity. MATERIALS AND METHODS: Role of Nutrients and to strengthen the Adaptive Immunity: The main aim of this review is to impart knowledge to the community about the importance of immune system to fight the diseases.

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Section: Fig 5: Functions Of Vitamin C In Human Bodysupporting

confidence: 80%

Section: Fig 7: Role Of Vitamin E In Infectious Diseases In Humansmentioning

confidence: 99%

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2020

IJPSR

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“…In the literature, there are some studies in which IL-6 is considered an important factor to induce fat loss by promoting white adipose tissue and browning lipolysis [ 30 ]. However, Wong et al [ 31 ] postulated the negative relationship between intake of vitamin C and the risk of developing metabolic syndrome, associated with obesity.…”

Section: Discussionmentioning

confidence: 99%

Effect of six weeks 1000 mg/day vitamin C supplementation and healthy training in elderly women on genes expression associated with the immune response - a randomized controlled trial

Żychowska

Grzybkowska

Zasada

et al. 2021

Journal of the International Society of Sports Nutrition

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Background In this study, we investigated the effects of supplementation and exercise on the expression of genes associated with inflammation like CCL2, CRP, IL1, IL6, IL10 mRNA in elderly women. Methods Twenty four participants divided randomly into two groups were subjected to 6 weeks of the same health training program (three times per week). SUP group (supplemented, n = 12, mean age 72.8 ± 5.26 years and mean body mass 68.1 ± 8.3 kg) received 1000 mg of Vitamin C/day during the training period, while CON group (control, n = 12, mean age 72.4 ± 5.5 years and body mass 67.7 ± 7.5 kg) received placebo. Results No significant changes in IL-1, IL-6, IL-10 and CRP mRNA were observed within and between groups. However, there was a clear tendency of a decrease in IL-6 (two-way ANOVA, significant between investigated time points) and an increase in IL-10 mRNA noted in the supplemented group. A significant decrease in CCL2 mRNA was observed only in the CON group (from 2^0.2 to 2^0.1, p = 0.01). Conclusions It can be concluded, that 6 weeks of supplementation and exercise was too short to obtain significant changes in gene expression in leukocytes, but supplementation of 1000 mg vitamin C positively affected IL-6 and IL-10 expression – which are key changes in the adaptation to training. However, changes in body mass, IL1 and CCL2 were positive in CON group. It is possible that Vitamin C during 6 weeks of supplementation could have different effects on the expression of individual genes involved in the immune response. Trial registration Retrospectively registered.

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“…In the literature there are some studies in which IL-6 is considered an important factor to induce fat loss by promoting white adipose tissue and browning lipolysis [30]. However, Wong et al [31] postulated the negative relationship between intake of vitamin C and risk of developing metabolic syndrome, associated with obesity.…”

Section: Discussionmentioning

confidence: 99%

Effect of six weeks 1000 mg/day Vitamin C supplementation and healthy training in elderly women on genes expression associated with immune response - a randomized controlled trial

Żychowska

Grzybkowska

Zasada

et al. 2020

Preprint

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BackgroundIn this study we investigated the effects of supplementation and exercise on the expression of genes associated with inflammation like CCL2, CRP, IL1, IL6, IL10 mRNA in elderly women.MethodsTwenty four participants divided randomly into two groups were subjected to 6 weeks of the same health training program (three times per week). SUP group (supplemented, n = 12, mean age 72.8 ± 5.26 years and mean body mass 68.1 ± 8.3 kg) received 1000 mg of Vitamin C/day during training period, while CON group (control, n = 12, mean age 72.4 ± 5.5 years and body mass 67.7 ± 7.5 kg) received placebo.ResultsNo significant changes in IL-1, IL-6, IL-10 and CRP mRNA were observed within and between groups. However, there was a clear tendency of a decrease in IL-6 (two-way ANOVA, significant for time) and an increase in IL-10 mRNA noted in the supplemented group. A significant decrease in CCL2 mRNA was observed only in the CON group (from 2^0.2 to 2^0.1, p = 0.01).ConclusionsIt can be concluded, that 6 weeks of supplementation and exercise was too short to obtain significant changes in gene expression in leukocytes, but supplementation of 1000 mg vitamin C positively affected IL-6 and IL-10 expression – which are key changes in the adaptation to training. However, changes in body mass, IL1 and CCL2 was positive in CON group. It is possible that Vitamin C during 6 weeks of supplementation could have different effects on the expression of individual genes involved in immune response.Trial registration: retrospectively registered.

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Vitamin C: A Review on its Role in the Management of Metabolic Syndrome

Cited by 52 publications

References 84 publications

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Effect of six weeks 1000 mg/day vitamin C supplementation and healthy training in elderly women on genes expression associated with the immune response - a randomized controlled trial

Effect of six weeks 1000 mg/day Vitamin C supplementation and healthy training in elderly women on genes expression associated with immune response - a randomized controlled trial

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