Are platelet indices useful in the evaluation of type 2 diabetic patients?

Alhadas, Kamilla R.; Santos, Sandra Neves dos; Freitas, Marcela Mara S.; Viana, Sophia Mara S. A.; Ribeiro, Luíz Cláudio; Costa, Mônica Barros

doi:10.5935/1676-2444.20160017

Cited by 26 publications

(50 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…24,25,26 Alterations in MPV, were reflected by poor glycaemic control which may be due to osmotic effect caused from increased glucose levels and its metabolites in blood. 15 In our study, coagulation parameters were prolonged in patients than control. Monitoring PT and APTT levels help in determining the risk of development of bleeding complications.…”

Section: Discussionsupporting

confidence: 47%

“…Hyperglycaemia affects calcium homeostasis and ultimately leads to cytoskeleton abnormalities and increased secretion of pro-aggregant factors. [13][14][15][16] The most common sites of bleeding in uremic patients are from puncture sites, mucosal and serosal surfaces (epistaxis, gastrointestinal and genitourinary bleeds, hemorrhagic pericarditis and pleuritis), and subdural hematomas. 17 Section: Pathology prevalence of peptic ulcers, angiodysplasia, mesenteric ischemia and diverticulosis; glomerular disease, acquired cystic, and polycystic kidney disease; pleural and pericardial inflammation; hypertension and head trauma due to falls.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the MPV was significantly higher in diabetics CKD patients than control groups who were known diabetics like other studies. 11,15 The increased MPV are reflected by large circulating platelets and is an independent risk factor for complications in diabetics. 15 Many studies have suggested that patients with diabetes have increased MPV when compared with non diabetic and, among the diabetics, those with vascular complications presented higher MPV values.…”

Section: Discussionmentioning

confidence: 99%

“…11,15 The increased MPV are reflected by large circulating platelets and is an independent risk factor for complications in diabetics. 15 Many studies have suggested that patients with diabetes have increased MPV when compared with non diabetic and, among the diabetics, those with vascular complications presented higher MPV values. 15,[19][20][21][22] Some studies showed that MPV was significantly higher in diabetics patients with vascular complications than in diabetics without complications, as in present study.…”

Section: Discussionmentioning

confidence: 99%

“…15 Many studies have suggested that patients with diabetes have increased MPV when compared with non diabetic and, among the diabetics, those with vascular complications presented higher MPV values. 15,[19][20][21][22] Some studies showed that MPV was significantly higher in diabetics patients with vascular complications than in diabetics without complications, as in present study. 22,23 Hyperglycaemia is associated with hypercoagulable state, which can lead to long term complications.…”

Section: Discussionmentioning

confidence: 99%

See 4 more Smart Citations

Coagulation Profile and Platelet Indices in Diabetes with Chronic Kidney Disease on Haemodialysis

Mittra¹,

Pandey²

2019

IJCMR

View full text Add to dashboard Cite

Introduction: Bleeding and thrombotic complications are high possibility in CKD. The present study was conducted to evaluate the platelets indices in patients on haemodialysis having Type 2 diabetes with CKD as compared to diabetic patients without CKD. Material and methods: 100 patients of ckd with diabetes and 100 patients of diabetes without ckd were studied over a period of seven months. The coagulation profile and platelet indices were compared. The coagulation profile and platelet indices were also compared in ckd patients before and after dialysis. Results: Increase in platelet indices mainly MPV and Platelet Distribution Width (PDW) with significant p-value 0.003 and 0.005 respectively in study group. PT and APTT both were increased in study group with significant p-value of 0.003. Platelet count improved but MPV and PDW values were slightly decreased with p-value < 0.005. PT showed not much difference whereas APTT values were higher compare to post dialysis with p-value<0.007. Conclusion: Basic coagulation profile like PT and APTT and MPV can predict long term complications of diabetic platelets on haemodialysis and these should be monitored in CKD patients.

show abstract

Section: Discussionsupporting

confidence: 47%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Coagulation Profile and Platelet Indices in Diabetes with Chronic Kidney Disease on Haemodialysis

Mittra¹,

Pandey²

2019

IJCMR

View full text Add to dashboard Cite

show abstract

White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

Adane

Asrie

Getaneh

et al. 2021

Clinical Laboratory Analysis

View full text Add to dashboard Cite

show abstract

Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot

Bashir¹,

Ali²

2018

BMC Hematol

View full text Add to dashboard Cite

BackgroundDiabetes mellitus is a very rampant metabolic disorder, particularly type II. It has many complications such as the septic foot. Diabetic septic foot (DSF) patients are at high risk for coagulation abnormalities as well as surgical hazards. Owing to the potential sequelae of coagulation and vascular abnormalities, this work aimed at studying the hemostatic state and platelet indices in diabetes type II patients with septic foot.MethodsA case-control study was conducted during the period from July to September 2017 at Dr. Awaad medical center, Red Sea State, Sudan. 57 diabetic patients with septic foot, aged between 17 and 78 years along with 57 non-diabetic subjects as control were enrolled. Sociodemographic data were collected using a structured questionnaire. Venipuncture blood was taken with necessary safety measures. Diabetes profile, coagulation studies as well as platelet indices were estimated. Data was analyzed using SPSS version 24.0 for windows. Ethical approval was considered and written consent from each participant was obtained.ResultsThe mean age of diabetic patients with septic foot and healthy controls were 48.49 ± 15.8 and 32.77 ± 14.0, respectively. The duration of the diabetes onset was 10.43 ± 9.5 years. Plasma prothrombin time (PT) value (12.61 ± 2.6 vs 13.67 ± 1.5, P < 0.009) was found to be significantly shorter in DSF compared to control. Plasma activated partial thromboplastin time (APTT) value was significant in diabetic septic foot (32.64 ± 5.2 vs 28.49 ± 4.13, P < 0.000), and thrombin time (TT) did not changed in DSF. Mean platelet volume (MPV), platelet distribution width (PDW), and platelet large cell ratio (P-LCR) values were significantly decreased in DSF compared to control (P < 0.013, 0.034, and 0.020, respectively). PDW values were positively correlated with PT, APTT, and D-Dimer (DD) (r = 0.28/p < 0.003, r = 0.29/p < 0.029, and r = 0.32/p < 0.016, respectively). FVIII activity (121.86 ± 174.4 vs 98.66 ± 31.83, P < 0.951) was insignificant with DSF, as the DD was also insignificant (P < 0.081).ConclusionDiabetes mellitus is associated with prothrombotic tendency. Hypercoagulable state in DSF is indicated by shortened PT finding. PDW is a manifesting evidence that proves the presence of more reactive and aggregable platelets in DSF patients.

show abstract

Are platelet indices useful in the evaluation of type 2 diabetic patients?

Cited by 26 publications

References 22 publications

Coagulation Profile and Platelet Indices in Diabetes with Chronic Kidney Disease on Haemodialysis

Coagulation Profile and Platelet Indices in Diabetes with Chronic Kidney Disease on Haemodialysis

White blood cells and platelet profiles of diabetic patients at University of Gondar specialized referral hospital: A comparative cross‐sectional study

Hemostatic state augmented with platelet indices among Sudanese diabetic septic foot

Contact Info

Product

Resources

About