Introduction: Drug-resistant tuberculosis remains a serious and growing public health problem. Among the measures recommended for its control, the involvement of all health professionals and services in the treatment and the implementation of an active case monitoring system stands out. Objectives: to describe the epidemiological profile of drug-resistant tuberculosis in the Regional Health Coordination East of São Paulo, from January 1 st , 2007 to December 31 st , 2016, and to analyze the perception of health professionals about the content and applicability of an instrument (MonitoraTBDR) to monitor cases in Primary Care. Methodology: it is an exploratory study, of an applied character, of a qualitative-quantitative approach, 24 professionals of health services hav been interviewed and carried out the analysis of content. Results: 208 patients, 63.5% men, 45.7% white, 82.2% between 20 and 59 years, 31.3% with 8 to 11 years of schooling, 56.7% employed, 51% from the state from São Paulo; 93.3% were clinically pulmonary diagnosis, 51.8% were primary, 52.4% were monoresistant, 41.8% were multiresistant, 4.4% were polyresistant and 1.4% extensively Drug-Resistant, 61.1% with hospital discharge due to healing ; 23.6% were alcoholics, 21.2% were drug users, 18.8% had HIV, 11.1% were diabetics, 5.8% were smokers; 75% without information on the treatment modality, 18.2% of the contacts were examined and 6.4% became ill. Most of the content of the MonitoraTBDR instrument was classified as clear, relevant, accurate, relevant and sufficient. The instrument was evaluated as feasible for the monitoring of the cases, however some limitations were found for its application, such as obtaining some information due to the difficulty of communication with the referral service and the time spent in consulting several data sources. Conclusions: MonitoraTBDR is a viable tool that will facilitate the monitoring of drug-resistant tuberculosis, especially if an integrated computerized system is established, that involves all services in charge of the patient. In addition, establishing an instrument to support nursing care may increase adherence to treatment.