Bioaccumulation of Tributyltin by Blue Crabs

Vannuci-Silva, Monizze; Menegário, Amauri Antônio; Franchi, Mariana; Brossi-Garcia, Ana Luiza; Souza, João Maximino de; Jr, Marcus A. G. de Araújo; Lopes, Monica A. F. S. Bindes G.; Govone, José Sílvio

doi:10.5935/0103-5053.20130209

Cited by 3 publications

(3 citation statements)

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“…Organotins can enter crustacean’s hemolymph from water, sediment, or food via gills and stomach ( 28 , 42 ). Once inside the animal, their fate depends on the processes of accumulation, biotransformation (metabolism), and elimination ( 16 , 28 , 42 , 43 ). In the hermit crab Clibanarius vittatus , assimilation of a single dose of TBT from food was higher than from water, and the levels of TBT in the tissues decreased progressively after 15 days, reaching null values after 75 days ( 44 ).…”

Section: Ots Effects On the Metabolismmentioning

confidence: 99%

“…When blue crabs Callinectes sapidus were fed with TBT-contaminated food, TBT levels in the whole abdomen peaked to 0.12 µg g −1 after 4 days of feeding, while DBT and MBT peaked to 0.39 and 0.35 µg g −1 after 8 and 12 days of feeding, respectively ( 54 ). In another study in which C. sapidus were fed TBT-contaminated food, TBT levels were higher in hepatopancreas compared to gills and muscle ( 43 ). In a third study in which C. sapidus was fed TBT-contaminated food, the respiration rate, the expression of P-450 3A (CYP3A), and heat shock proteins (HSPs) in the hepatopancreas increased, indicating that the crabs were stressed by TBT ( 51 ).…”

Section: Ots Effects On the Metabolismmentioning

confidence: 99%

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Effects of Organotins on Crustaceans: Update and Perspectives

2018

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Organotins (OTs) are considered some of the most toxic chemicals introduced into aquatic environments by anthropogenic activities. They are widely used for agricultural and industrial purposes and as antifouling additives on boat hull’s paints. Even though the use of OTs was banned in 2008, elevated levels of OTs can still be detected in aquatic environments. OTs’ deleterious effects upon wildlife and experimental animals are well documented and include endocrine disruption, immunotoxicity, neurotoxicity, genotoxicity, and metabolic dysfunction. Crustaceans are key members of zooplankton and benthic communities and have vital roles in food chains, so the endocrine-disrupting effects of tributyltin (TBT) on crustaceans can affect other organisms. TBT can disrupt carbohydrate and lipid homeostasis of crustaceans by interacting with retinoid X receptor (RXR) and crustacean hyperglycemic hormone (CHH) signaling. Moreover, it can also interact with other nuclear receptors, disrupting methyl farnesoate and ecdysteroid signaling, thereby altering growth and sexual maturity, respectively. This compound also interferes in cytochrome P450 system disrupting steroid synthesis and reproduction. Crustaceans are also important fisheries worldwide, and its consumption can pose risks to human health. However, some questions remain unanswered. This mini review aims to update information about the effects of OTs on the metabolism, growth, and reproduction of crustaceans; to compare with known effects in mammals; and to point aspects that still needs to be addressed in future studies. Since both macrocrustaceans and microcrustaceans are good models to study the effects of sublethal TBT contamination, novel studies should be developed using multibiomarkers and omics technology.

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Section: Ots Effects On the Metabolismmentioning

confidence: 99%

Section: Ots Effects On the Metabolismmentioning

confidence: 99%

Effects of Organotins on Crustaceans: Update and Perspectives

2018

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“…Since only few atomic spectrometric techniques are selective for the determination of species, sample pretreatments becomes a prominent feature that enables the possibility to discriminate between total content of a trace element and the content of each individual chemical form in which it occurs. The quantitation of individual forms of an analyte is termed speciation analysis (specific-species determination); and most analytical methods employed for speciation involve the hyphenation of an atomic spectrometric detector with a separation technique namely chromatography (LC or GC) [7,12,[16][17][18][19][20][21][22][23][24], capillary electrophoresis (CE) [25][26][27], solid phase extraction (SPE) [13,[28][29][30][31][32][33][34][35][36][37], liquid-liquid extraction (LLE) with its variants [38][39][40][41][42][43], among others. The vapor generation is thus a derivatization step after the separation process that preconcentrate further the analyte(s) with considerable improvements in selectivity [6].…”

Section: Introductionmentioning

confidence: 99%