Fiddler crabs (Minuca burgersi) were kept under controlled conditions in an experimental laboratory to assess their ability to secrete metallic contaminants by ecdysis. They were fed different copper (Cu) and lead (Pb) concentrations, with subsequent measurement of heavy metals concentration in the released and renewed exoskeletons. Our results show that these crabs can purify both metals during ecdysis, demonstrating to be an efficient way to decontaminate these toxic components, besides accrediting this native species as a strong indicator of contamination in estuarine environments. Our results also reinforce the need for attention to the contamination characterization in crustaceans before and after ecdysis to avoid underestimation.