Redox Pathways of Aliskiren Based on Experimental and Computational Approach and Its Voltammetric Determination

Pamuk, Deniz; Ece, Abdulilah; Canel, Esin; Kılıç, Esma

doi:10.5935/0103-5053.20130162

Cited by 16 publications

(24 citation statements)

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“…19−22 In such mechanisms, the electroactive group was protonated before the electron transfer, which may be considered a classical acid catalyzed reduction. In these mechanisms the transfer of electron(s) needs much more potentials at higher pH 14,16,22 as we observed during the present study. Peak potentials are pH independent in neutral and alkaline solutions.…”

Section: Effect Of Phsupporting

confidence: 73%

“…14−16,21−24 As shown in the Scheme, there are mainly 4 reducible groups in the structure of FNX: etheric oxygens, a carbonyl group, azomethine in one 5-membered ring, and chlorine as a leaving group. 14,19,21,22 Taking all the experimental studies into consideration, reduction of the carbonyl group to its corresponding alcohol by 2 protons and 2 electrons in such a way like acid catalyzed reduction and reduction of the C=N group to CH-NH again by 2 protons and 2 electrons could be thought of as reduction mechanisms.…”

Section: Constant Potential Bulk Electrolysis (Be) and The Number Of mentioning

confidence: 99%

“…LOD and LOQ values were calculated from the electro-reduction peak current using the following equations: LOD = 3s/m and LOQ = 10s/m (s is the standard deviation of intercept and m is the slope of calibration curve) 14,16 and LOD = 0.07 µM and LOQ = 0.24 µ M as given in Table 1.…”

Section: 16mentioning

confidence: 99%

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Reduction behavior of fenoxaprop-p-ethyl and its voltammetric determination

Eş¹

2015

Turk J Chem

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Abstract:The reduction behavior of fenoxaprop-p-ethyl (FNX) was studied on a hanging mercury drop electrode. FNX showed 2 reduction peaks at about -0.7 V and at about -0.9 V versus Ag/AgCl/3.0 M KCl in Britton-Robinson buffer at pH 4.8. Both reductions were irreversible and adsorption was effective. The reduction peaks were assigned to the reduction of C=N to CH-NH and the reduction of C=O to CH-OH. Square-wave voltammetry has been proposed and

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Section: Effect Of Phsupporting

confidence: 73%

Section: Constant Potential Bulk Electrolysis (Be) and The Number Of mentioning

confidence: 99%

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Reduction behavior of fenoxaprop-p-ethyl and its voltammetric determination

Eş¹

2015

Turk J Chem

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“…Then the same procedures given in our previous studies (Tas ßdemir et al, 2012;Pamuk et al, 2013;Zorluog˘lu et al, 2013) were followed to prepare tablet solutions and serum samples.…”

Section: Preparation Of Spectraceft Tablets and Human Serum Samplesmentioning

confidence: 99%

“…In this instance evaluation of electrochemical parameters of CTP may be of great importance. Theoretical calculations by which molecular orbitals could be mapped according to their relative energies were also found to be useful as a value added tool to enlighten oxidation-reduction mechanisms by (Tas ßdemir et al, 2012;Pamuk et al, 2013;Zorluog˘lu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Electrochemistry of cefditoren pivoxil and its voltammetric determination

Taşdemir

2016

Arabian Journal of Chemistry

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Electrochemical behavior of cefditoren pivoxil (CTP) was studied via experimental electrochemical methods and theoretical calculations performed at B3LYP/6-31+G(d)//AM1 level. Experimental studies were carried out based on an irreversible 4eÀ/4H+ reduction peak at ca. À0.8 V on hanging mercury drop electrode (HMDE) and irreversible 1eÀ/1H+ oxidation of CTP at ca. 0.8 V on glassy carbon electrode (GCE) versus Ag/AgCl, KCl (3.0 M) in Britton-Robinson buffer at pH 6.0 and 4.0, respectively. Tentative reduction and oxidation mechanisms were proposed based on computational and experimental results. Square-wave adsorptive stripping voltammetric methods have been developed and validated for quantification of CTP in different samples. Linear working range was established as 0.15-15.0 lM for HMDE and 1.0-50.0 lM for GCE. Limit of quantification (S/N = 10) was calculated to be (0.10 ± 0.02) lM and (0.80 ± 0.03) lM for HMDE and GCE, respectively. Methods were successfully applied to assay the drug in tablets and human serum with good recoveries between (99.2 ± 11.6) % and (102.5 ± 9.5) % having relative standard deviation less than 10%. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Quaternary Ammonium Based Carboxyl Functionalized Ionic Liquid for Covalent Immobilization of Horseradish Peroxidase and Development of Electrochemical Hydrogen Peroxide Biosensor

et al. 2020

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A novel electrochemical biosensor was developed using a judiciously designed platform for the rapid and accurate determination of hydrogen peroxide (H2O2). The horseradish peroxidase (HRP) based biosensor was constructed by covalent anchoring of the enzyme to a newly synthesized quaternary ammonium‐based carboxyl functionalized ionic liquid (TBA−COOH−IL) immobilized on a multiwalled carbon nanotube deposited glassy carbon electrode (MWCNT/GCE). A stable amide bond is formed between HRP enzyme and IL by utilizing the terminal −NH2 of HRP and −COOH groups of TBA−COOH−IL, while the pi‐pi stacking holds the TBA−COOH−IL firmly on the MWCNT/GCE and forms HRP/TBA−COOH−IL/MWCNT/GCE. Thus fabricated HRP/TBA−COOH−IL/MWCNT/GCE displayed a well‐resolved redox peak at a formal potential (E°’) of −0.32 V, which corresponds to the concealed FeIII/FeII redox centre of the immobilized HRP enzyme. Further, the developed biosensor was employed for the electrocatalytic determination of H2O2 in static and dynamic conditions, which showed a wide linear range from 0.02 to 4.30 mM with a high sensitivity and low detection limit of 160.6 μA mM−1 cm−2 and 6 μM, respectively. The excellent performance of the fabricated biosensor is attributed to the stable covalent anchoring of freely water‐soluble enzyme on the newly designed, highly conducting and biocompatible platform. Furthermore, the fabricated biosensor exhibited good reproducibility with an extended long‐term stability.

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Redox Pathways of Aliskiren Based on Experimental and Computational Approach and Its Voltammetric Determination

Cited by 16 publications

References 1 publication

Reduction behavior of fenoxaprop-p-ethyl and its voltammetric determination

Reduction behavior of fenoxaprop-p-ethyl and its voltammetric determination

Electrochemistry of cefditoren pivoxil and its voltammetric determination

Quaternary Ammonium Based Carboxyl Functionalized Ionic Liquid for Covalent Immobilization of Horseradish Peroxidase and Development of Electrochemical Hydrogen Peroxide Biosensor

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