Electrochemistry of cefditoren pivoxil and its voltammetric determination

Abstract

Electrochemical behavior of cefditoren pivoxil (CTP) was studied via experimental electrochemical methods and theoretical calculations performed at B3LYP/6-31+G(d)//AM1 level. Experimental studies were carried out based on an irreversible 4eÀ/4H+ reduction peak at ca. À0.8 V on hanging mercury drop electrode (HMDE) and irreversible 1eÀ/1H+ oxidation of CTP at ca. 0.8 V on glassy carbon electrode (GCE) versus Ag/AgCl, KCl (3.0 M) in Britton-Robinson buffer at pH 6.0 and 4.0, respectively. Tentative reduction and oxidation mechanisms were proposed based on computational and experimental results. Square-wave adsorptive stripping voltammetric methods have been developed and validated for quantification of CTP in different samples. Linear working range was established as 0.15-15.0 lM for HMDE and 1.0-50.0 lM for GCE. Limit of quantification (S/N = 10) was calculated to be (0.10 ± 0.02) lM and (0.80 ± 0.03) lM for HMDE and GCE, respectively. Methods were successfully applied to assay the drug in tablets and human serum with good recoveries between (99.2 ± 11.6) % and (102.5 ± 9.5) % having relative standard deviation less than 10%. ª 2014 Production and hosting by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

Rapid and Sensitive Electrochemical Assay of Cefditoren with MWCNT/Chitosan NCs/Fe2O3 as a Nanosensor

“…The LOQ and LOD values for CFT obtained from the modified GCE with MWCNT/chitosan NCs/Fe 2 O 3 were also lower than the LOQ and LOD values for CFT with an unmodified GCE, as reported by Taşdemir [3]. In conclusion, our suggested nanosensor could, with ease, detect and determine CFT at concentration levels lower than the concentration indicated in the literature for this linear range (Table 4).…”

“…Moreover, the slope of the straight line obtained from plotting the potential of anodic peak(Epa) versus the log ν was equal to 2.303 × RT 2(1−α)nF (Laviron equation), where n is the number of electrons transferred, R is the gas constant (8.314 J/mol/K), T is the temperature (298 • K), and F is Faraday's constant (96,485 C/mol) [3]. The α value of 0.5 was calculated by assuming that one electron was involved in the rate-determining step of CFT oxidation.…”

“…Several analytical techniques have been performed for the determination of cefditoren, including LC-MS techniques [2], voltammetrics [3], spectrophotometry [4][5][6], chemiluminescence [7], micellar liquid chromatography [8], high-performance liquid chromatography (HPLC) [5,[9][10][11][12][13], Fourier transform infrared spectroscopy [14], potentiometry using ion-selective electrodes [15], and thin-layer chromatography (TLC) [5]. Electrochemical techniques are significant for monitoring and sensing pharmaceuticals because of their specific properties such as a fast response, sensitivity, no pre-treatment, simplicity, low organic solvent consumption, and low cost versus traditional analysis methods [16].…”