Validated electroanalytical determination of flavoxate hydrochloride and tolterodine tartrate drugs in bulk, dosage forms and urine using modified carbon paste electrodes

Attia, Ali K.; Frag, Eman Yossri; Ahmed, Heba E.

doi:10.1016/j.arabjc.2016.07.015

Cited by 8 publications

(3 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several analytical methods have been developed for the determination of flavoxate such as the most recent HPLC [27,28], spectrophotometric [27,29] and fluorimetric methods [30]. Electrochemical methods [31][32][33][34][35] have been also developed for the determination of flavoxate. None of the published electrochemical methods [31][32][33][34][35] utilized screen printed electrodes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Design of Solid‐contact Ion‐selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

et al. 2020

View full text Add to dashboard Cite

Eco-friendly solid-contact ion selective electrode was fabricated and optimized for the determination of flavoxate hydrochloride in presence of its main metabolite. The process is based on carbon screen printed electrode and polyvinyl chloride polymeric sensing membrane. The first optimization step involved the ionophore selection through screening various ionophores, where calix[4]arene showed the highest affinity towards flavoxate. The second step, a graphene nanocomposite interlayer was employed as the ion-to-electron transducer between the carbon electrode and the polymeric ion sensing membrane. The graphene layer decreased the potential drift down to < 500 μV/h and improved the electrode stability.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Electrochemical methods [31][32][33][34][35] have been also developed for the determination of flavoxate. None of the published electrochemical methods [31][32][33][34][35] utilized screen printed electrodes. They didn't study the electrodes' stability via the signal drift and water layer tests.…”

Section: Introductionmentioning

confidence: 99%

Design of Solid‐contact Ion‐selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

et al. 2020

View full text Add to dashboard Cite

show abstract

“…A literature review revealed that many analytical methods such as direct [11,12,13] and derivative [14] ultraviolet-visible (UV-Vis) spectrophotometric, spectrofluorometric [15,16], high-performance liquid chromatography (HPLC) [17,18,19,20,21], ultra-performance liquid chromatography (UPLC) [22], liquid chromatography (LC)-mass spectrometry (MS) [23,24], and capillary zone electrophoresis [25,26] methods for the determination of MOX alone and in combination with other drugs in different formulations and in different biological samples. Bibliography data showed that UV-Vis spectrophotometric [27], HPLC [28,29,30,31,32,33,34], electroanalytical [35], and capillary electrophoresis methods [36] were reported for the determination of FLX alone or in combination with other drugs. Only one reversed-phase (RP)-HPLC method has been reported for the concurrent estimation of MOX and FLX in formulation [37].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Determination of Moxifloxacin and Flavoxate by RP-HPLC and Ecofriendly Derivative Spectrophotometry Methods in Formulations

Attimarad

Chohan

Balgoname

2019

IJERPH

View full text Add to dashboard Cite

Simple, fast, and precise reversed-phase (RP)-high-performance liquid chromatography (HPLC) and two ecofriendly spectrophotometric methods were established and validated for the simultaneous determination of moxifloxacin HCl (MOX) and flavoxate HCl (FLX) in formulations. Chromatographic methods involve the separation of two analytes using an Agilent Zorbax SB C18 HPLC column (150 mm × 4.6 mm; 5 µm) and a mobile phase consisting of phosphate buffer (50 mM; pH 5): methanol: acetonitrile in a proportion of 50:20:30 v/v, respectively. Valsartan was used as an internal standard. Analytes were monitored by measuring the absorbance of elute at 299 nm for MOX and 250 nm for FLX and valsartan. Two environmentally friendly spectrophotometric (first derivative and ratio first derivative) methods were also developed using water as a solvent. For the derivative spectrophotometric determination of MOX and FLX, a zero-crossing technique was adopted. The wavelengths selected for MOX and FLX were −304.0 nm and −331.8 nm for the first derivative spectrophotometric method and 358.4 nm and −334.1 nm for the ratio first-derivative spectrophotometric method, respectively. All methods were successfully validated, as per the International Conference on Harmonization(ICH) guidelines, and all parameters were well within acceptable ranges. The proposed analytical methods were successfully utilized for the simultaneous estimation of MOX and FLX in formulations.

show abstract

Simultaneous ultra-sensitive analysis of tamsulosin hydrochloride and tolterodine tartrate binary mixture in their dosage form via high-performance thin-layer chromatography with fluorimetric detection

Rizk

Mahmoud

Azab

2022

JPC-J Planar Chromat

View full text Add to dashboard Cite

A simple, sensitive, selective, and stability-indicating high-performance thin-layer chromatography method with fluorescence detection was developed for the analysis of a mixture of tamsulosin hydrochloride and tolterodine tartrate, used in the management of benign prostatic hyperplasia in their laboratory-prepared binary mixture and dosage form. The separation was employed on thin-layer chromatography silica gel 60 aluminum sheets. As developing system, ethyl acetate–n-hexane–diethylamine (9:3:1, V/V) was used. Tamsulosin and tolterodine had retention factors (RF) of 0.40 ± 0.03 and 0.85 ± 0.03, respectively. A 225 nm excitation wavelength was used for the fluorescence detection. Linearity was in the range of 10.0–200.0 and 100.0–900.0 ng/band for tamsulosin and tolterodine, respectively. The method was validated successfully according to the International Council for Harmonisation guidelines. Our suggested method for determining tamsulosin and tolterodine in their dosage forms and in the presence of their degradation products could be conveniently applied in quality-control laboratories.

show abstract

Validated electroanalytical determination of flavoxate hydrochloride and tolterodine tartrate drugs in bulk, dosage forms and urine using modified carbon paste electrodes

Cited by 8 publications

References 30 publications

Design of Solid‐contact Ion‐selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

Design of Solid‐contact Ion‐selective Electrode with Graphene Transducer Layer for the Determination of Flavoxate Hydrochloride in Dosage Form and in Spiked Human Plasma

Simultaneous Determination of Moxifloxacin and Flavoxate by RP-HPLC and Ecofriendly Derivative Spectrophotometry Methods in Formulations

Simultaneous ultra-sensitive analysis of tamsulosin hydrochloride and tolterodine tartrate binary mixture in their dosage form via high-performance thin-layer chromatography with fluorimetric detection

Contact Info

Product

Resources

About