Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents
            in the pre-dialysis of chronic kidney disease

Costa, Nathália Cristina Pereira da; Canhestro, Mônica Ribeiro; Soares, Cristina M. Bouissou; Rodrigues, Juliana Scudilio

doi:10.5935/0101-2800.20170044

Cited by 5 publications

(5 citation statements)

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“…This general effect of renal failure is illustrated by the poorer vaccination responses to hepatitis B observed among patients with chronic renal disease as compared to the general population. [9][10][11] These studies have also shown quantitative decreases in protective antibodies over time. In this respect, our findings for lower incidences of transfusion-induced RBC alloimmunization in patients with renal failure seem compatible.…”

Section: Discussionmentioning

confidence: 85%

“…This condition has been characterized by a general immune dysfunction, including ineffective dendritic cell, B‐cell, and T‐cell responses, 3,24 all crucial for initiating a humoral response. This general effect of renal failure is illustrated by the poorer vaccination responses to hepatitis B observed among patients with chronic renal disease as compared to the general population 9–11 . These studies have also shown quantitative decreases in protective antibodies over time.…”

Section: Discussionmentioning

confidence: 99%

“…Both immune activation due to hyperinflammation and subsequent oxidative stress 8 and immune suppression characterized by quantitative and qualitative deficiencies of the T‐ and B‐cell compartments hallmark this disease. Illustrating this, severe renal failure is associated with a higher susceptibility to both bacterial and viral infections, poorer responses to vaccination, and decreased antibody production to specific stimuli 9–11 …”

Section: Introductionmentioning

confidence: 99%

“…Illustrating this, severe renal failure is associated with a higher susceptibility to both bacterial and viral infections, poorer responses to vaccination, and decreased antibody production to specific stimuli. [9][10][11] In this respect, the general impaired cellular immunology may similarly modulate RBC alloimmunization. Previous studies have primarily focused on alloimmunization in non-Caucasian multitransfused patients with chronic renal failure undergoing hemodialysis and showed wide ranges of normal to elevated alloimmunization rates.…”

Section: Introductionmentioning

confidence: 99%

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Association between renal failure and red blood cell alloimmunization among newly transfused patients

et al. 2020

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Background Renal failure and renal replacement therapy (RRT) affect the immune system and could therefore modulate red blood cell (RBC) alloimmunization after transfusion. Study Design and Methods We performed a nationwide multicenter case‐control study within a source population of newly transfused patients between 2005 and 2015. Using conditional multivariate logistic regression, we compared first‐time transfusion‐induced RBC alloantibody formers (N = 505) with two nonalloimmunized recipients with similar transfusion burden (N = 1010). Results Renal failure was observed in 17% of the control and 13% of the case patients. A total of 41% of the control patients and 34% of case patients underwent acute RRT. Renal failure without RRT was associated with lower alloimmunization risks after blood transfusion (moderate renal failure: adjusted relative rate [RR], 0.82 [95% confidence interval (CI), 0.67‐1.01]); severe renal failure, adjusted RR, 0.76 [95% CI, 0.55‐1.05]). With severe renal failure patients mainly receiving RRT, the lowest alloimmunization risk was found in particularly these patients [adjusted RR 0.48 (95% CI 0.39‐0.58)]. This was similar for patients receiving RRT for acute or chronic renal failure (adjusted RR, 0.59 [95% CI, 0.46‐0.75]); and adjusted RR, 0.62 [95% CI 0.45‐0.88], respectively). Conclusion These findings are indicative of a weakened humoral response in acute as well as chronic renal failure, which appeared to be most pronounced when treated with RRT. Future research should focus on how renal failure and RRT mechanistically modulate RBC alloimmunization.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between renal failure and red blood cell alloimmunization among newly transfused patients

et al. 2020

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“…Bu yüzden hepatit B aşısının son dozunu takiben 2-3. ay ve sonrasında yıllık olarak antikor takibi önerilmektedir. HBsAb titresi 10 mIU/ml altında olan hastalara rapel doz yapılmalıdır (3,(16)(17)(18). Misurac ve ark.…”

Section: Discussionunclassified

Kronik Böbrek Yetmezlikli Çocuk Sahibi Olan Ebeveynlerin Aşılar Hakkındaki Bilgi Düzeyi

Yazarli¹,

Taktak²,

Çelakıl³

2021

jchild

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Kronik böbrek yetersizliği (KBY) tanılı çocuklarda yüksek enfeksiyon riski nedeniyle aşılar önemli bir koruyucu sağlık hizmetidir. Bu çalışmada, KBY tanılı çocuklarda aşılanma oranı ve bu oranı etkileyen faktörler incelendi. Yöntem: Tanımlayıcı kesitsel tipteki çalışmamıza Kasım 2020-Ocak 2021 tarihleri arasında, KBY tanısı ile takipli 0-18 yaş arası 81 hastanın ebeveynleri alındı. Ebeveynlere 29 sorudan oluşan anket formu yüz yüze görüşme tekniği ile uygulandı. Ebevenylerin demografik özellikleri, hastaların ulusal aşılama takviminde olan aşılarla aşılanma durumu ve ulusal aşı takviminde olmayan meningokok, influenza ve human papilloma virüs aşısı ile aşılanma durumları kaydedildi. Ulusal aşılama takvimine çocuğun aşılanma zamanından sonra eklenen aşıların tamamlanıp tamamlanmadığı ve aşı yaptırmayan ailelere aşı yaptırmama nedenleri soruldu. Bulgu: Hastaların ulusal aşı takvimine göre aşılanma oranının %85,2 (n=69) olduğu ve ebeveynlerin %75,3'ünün (n=61) aşı eğitimi aldığı görüldü. Aşı eğitimi alan ebeveynlerin çocuklarının ulusal aşı takvimindeki aşılarla aşılanma oranı eğitim almayan ebeveynlerin çocuklarına göre istatistiksel olarak yüksek saptandı (p<0,001). Aylık geliri yüksek olan hastalarda influenza, meningokok, hepatit A, suçiçeği aşılanma oranı aylık geliri düşük olan hastalara göre istatistiksel olarak yüksek saptandı (sırasıyla p<0,001; p<0,001; p=0,010; p=0,029). En az bilinen ve yaptırılan aşının human papilloma virüs aşısı olduğu görüldü. Sonuç: KBY tanılı hastaların aşılanma oranının düşük olduğu saptandı. Ulusal aşı takvimine hastanın aşılanma zamanından sonra eklenen ya da ulusal aşı takviminde olmayan aşılar hakkında ailelerin bilgi düzeyinin çok düşük olduğu görüldü. Ebeveynlere yönelik aşı eğitimlerinin arttırılması ve hastaların aşılanma durumunun daha dikkatli takip edilmesi gerekmektedir.

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Prevalence of serum markers of infection and naturally acquired immunity to hepatitis B virus in transfused children treated at a children’s hospital in Salvador, Bahia: A cross-sectional study

Martinez

D'Arede

Almeida

et al. 2018

Pediatric Hematology and Oncology

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Monitoring of post-vaccination anti-HBs titles vaccine in children and adolescents in the pre-dialysis of chronic kidney disease

Abstract: The majority of the studied population was vaccinated by PNI and showed excellent anti-HBs titer levels, even experiencing a progressive reduced response over the time.

Cited by 5 publications

References 0 publications

Association between renal failure and red blood cell alloimmunization among newly transfused patients

Association between renal failure and red blood cell alloimmunization among newly transfused patients

Kronik Böbrek Yetmezlikli Çocuk Sahibi Olan Ebeveynlerin Aşılar Hakkındaki Bilgi Düzeyi

Prevalence of serum markers of infection and naturally acquired immunity to hepatitis B virus in transfused children treated at a children’s hospital in Salvador, Bahia: A cross-sectional study

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