GSTM1 and GSTT1 genes null polymorphisms in kidney cancer susceptibility: evidence based on a meta-analysis

Abstract

Based on the results obtained, we conclude that the GSTM1 and GSTT1 null polymorphisms are not associated with the risk of developing renal cancer, since they have limited role, if there is any on effective contribution in the development of renal tumors.

Gstm1/Gstt1 is essential for reducing cisplatin ototoxicity in CBA/CaJ mice

“…No difference in the thresholds at 4–32 kHz was noted between the Gstm1 −/− and WT mice or the Gstt1 −/− and WT mice (Figure 3A–E). Numerous studies have identified the Gstm1 / Gstt1 double null genotype in humans and found it to be related to enhanced risk of many complex disorders involving various cancer types 30–34 . Then, we crossed the Gstm1 −/− and Gstt1 −/− mice to obtain mice with ablation of both Gstm1 and Gstt1 .…”

“…Numerous studies have identified the Gstm1/Gstt1 double null genotype in humans and found it to be related to enhanced risk of many complex disorders involving various cancer types. [30][31][32][33][34] Then, we crossed the Gstm1 −/− and Gstt1 −/− mice to obtain mice with ablation of both Gstm1 and Gstt1. However, the Gstm1/Gstt1-DKO mice also showed normal ABR thresholds at 4-32 kHz for up to 12 months (Figure 3F-H).…”

Research Article Association study between <i>GSTM1</i> and <i>GSTT1</i> genotypes and other possible risk factors in prostate cancer patients in a population from southwest Bahia, Brazil

“…All cytosolic GSTs present genetic polymorphisms in human populations and are subdivided into six classes. Among them, the most studied classes are the Mu-class GSTs, whose proteins are encoded by GSTM1 gene, and the Theta class GSTs, encoded by GSTT1 gene (Silva et al, 2015). GSTM1 gene, chromosomal location 1p13.3, has three described alleles: two characterized as non-null with functional activity and one null GSTM1 genotype, described as an allelic version of gene deletion (Wei et al, 2012;Sá et al, 2014).…”