Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review

Although the genetic basis and pathogenesis of type 1 diabetes have been studied extensively, how host responses to environmental factors might contribute to autoantibody development remains largely unknown. Here, we use longitudinal blood transcriptome sequencing data to characterize host responses in children within 12 months prior to the appearance of type 1 diabetes-linked islet autoantibodies, as well as matched control children. We report that children who present with insulin-specific autoantibodies first have distinct transcriptional profiles from those who develop GADA autoantibodies first. In particular, gene dosage-driven expression of GSTM1 is associated with GADA autoantibody positivity. Moreover, compared with controls, we observe increased monocyte and decreased B cell proportions 9-12 months prior to autoantibody positivity, especially in children who developed antibodies against insulin first. Lastly, we show that control children present transcriptional signatures consistent with robust immune responses to enterovirus infection, whereas children who later developed islet autoimmunity do not. These findings highlight distinct immune-related transcriptomic differences between case and control children prior to case progression to islet autoimmunity and uncover deficient antiviral response in children who later develop islet autoimmunity.

show abstract

GSTT1 and GSTM1 Polymorphisms with Human Papillomavirus Infection in Women from Southern Brazil: A Case-control Study

Bortolli

Vieira

Treco

et al. 2021

Preprint

Self Cite

View full text Add to dashboard Cite

Background Some important factors for the most common sexually transmitted infection (STI) in the world caused by human papillomavirus (HPV) are well defined as early sexual activity, use of contraceptives, tobacco smoking, immunological and genetic factors. This study aimed to investigate the relationship between polymorphisms, GSTM1 and GSTT1, and HPV infection and associated risk factors in a group of women assisted in the public health system in southwestern Paraná, Brazil. Methods and results A case-control study was designed, in which the case group consisted of 21 women with HPV, matched by age, with the control group, 84 women without the virus. Viral detection was conducted via Polymerase Chain Reaction (PCR) and GSTM1 and GSTT1 genotyping by Multiplex PCR. The results showed that the GSTT1 null allele was a protective factor against infection (ORadj: 0.219; 95% CI 0.078-0.618; p=0.004). No relationship was observed for the GSTM1 gene. The smoking habit was defined as a risk factor (ORadj: 3.678; 95% CI 1.111-12.171; p=0.033), increasing the chance for the presence of HPV by up to 3.6 times.Conclusion In short, this study showed in an unprecedented way, the relationship between GSTM1 and GSTT1 genetic polymorphisms and HPV. The relationship found portrays protection from viral infection and not from susceptibility in the female population of southern Brazil.

show abstract

Relationship between GSTM1 and GSTT1 polymorphisms and HPV infection: a systematic review

Cited by 4 publications

References 32 publications

GSTT1 and GSTM1 polymorphisms with human papillomavirus infection in women from southern Brazil: a case–control study

GSTT1 and GSTM1 polymorphisms with human papillomavirus infection in women from southern Brazil: a case–control study

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection

GSTT1 and GSTM1 Polymorphisms with Human Papillomavirus Infection in Women from Southern Brazil: A Case-control Study

Contact Info

Product

Resources

About