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citations
Cited by 46 publications
(43 citation statements)
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References 30 publications
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“…1,16,21) It was, therefore, expected that there was some correlation between these two UTs. The lack of any correlation between them can be attributed in part to diŠerences in their protein binding capacities.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…1,16,21) It was, therefore, expected that there was some correlation between these two UTs. The lack of any correlation between them can be attributed in part to diŠerences in their protein binding capacities.…”
Section: Discussionmentioning
confidence: 99%
“…15,16) Such observations appear somewhat curious because plasma IS levels and Scr are considered to vary independently in HD patients. The mechanism behind their correlation is not yet fully understood.…”
Section: Introductionmentioning
confidence: 99%
“…65 In non-dialysis-dependent CKD patients, IS has been found to be positively associated with bone formation rate. 66 IS is a ligand of the aryl-hydrocarbon receptor (AhR), a transcriptional regulator that has been shown to cause podocyte injury. 67 Similar to p -cresol sulfate, IS is also highly protein bound, preventing it from being effectively removed by hemodialysis.…”
Section: Pathogenesismentioning
confidence: 99%
“…Higher IS serum levels have been associated with renal progression (reduction in estimated GFR >50% from baseline or progression to ESRD); its predictive power, however, was reduced when paracresyl sulfate (pCS) was added to the model [47] . Even though some studies have suggested that IS may play a role in the uremia-related musculoskeletal disorders, such as renal osteodystrophy [48] , no study so far has examined the association between IS levels and bone-specific outcomes, such as fracture.…”
Section: Protein-bound Uremic Toxinsmentioning
confidence: 99%