STEROLS AND VOLATILE COMPOUNDS OF THE FRESHWATER SPONGE<i>TROCHOSPONGILLA PAULULA</i>(BOWERBANK, 1863)

Barros, Iuri Bezerra de; Ribeiro, Camila Silva; Veiga, Valdir Florêncio da

doi:10.5935/0100-4042.20150134

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“…For the Neotropical region, biochemical researches were concentrated on studies of sterols and volatile constituents of sponges from the Amazon region , De Barros et al 2015. However, since the Neotropical region concentrates the greatest diversity of freshwater sponges (approximately 65 species), the number of studies found for the area of knowledge Biochemistry and Physiology of freshwater sponges in this region can be considered scarce, and new research efforts must be considered.…”

Section: Discussionmentioning

confidence: 99%

Trends and Gaps in Scientific Production on Freshwater Sponges

2020

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Researchers working with freshwater sponges are faced with old, unresolved issues and fragmented knowledge. In the present study, a systematic search of the studies on continental sponges, from the 21 st century, was carried out to identify trends and gaps in this restricted area of knowledge, using the scientific productions available on the Web of Science. The publication of scientific papers involving studies with freshwater sponges has increased over the years, with a decline in the last two years (2016-2017). The focus of the Brazilian studies included taxonomy and ecology, while Russian researchers contributed with knowledge about the genetic, phylogenetic and molecular biology of endemic sponges of the region. Eight sub disciplines were identified: Biochemistry and

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Section: Discussionmentioning

confidence: 99%

Trends and Gaps in Scientific Production on Freshwater Sponges

2020

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“…Sterols from sponges have received attention because they present patterns of branches that distinguish them from all other living organisms (de Barros et al. 2013 , 2015 ; Dembitsky et al. 2003 ; Manconi et al.…”

Section: Introductionmentioning

confidence: 99%

Further insight into the bioactivity of the freshwater sponge Ochridaspongia rotunda

Talevska

Pejin

Berić

et al. 2017

Pharmaceutical Biology

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Context: Bioprospection has become a dynamic scientific field that explores novel possibilities for the implementation of natural products in medicine and pharmacy. Compared to marine species from all kingdoms, freshwater species have been highly neglected.Objective: This work focuses on the screening of acetylcholinesterase inhibitory (AChE) and mutagenic activities of the acetone extract (obtained by maceration) of the freshwater sponge Ochridaspongia rotunda Arndt (Malawispongiidae) in vitro.Materials and methods: AChE inhibitory activity was evaluated both in liquid (five different concentrations of the extract, from 1 to 100 μg/mL) and in solid (seven different concentrations of the extract, from 0.5 to 10.0 μg) by methods well described in literature, while mutagenicity was estimated using the Ames test (four different concentrations of the extract, from 0.106 to 1.328 mg/plate).Results:Ochridaspongia rotunda acetone extract exhibited promising AChE inhibitory activity in a dose-dependent manner both in liquid (IC50 23.07 μg/mL) and in solid (1.50 μg). Furthermore, the Ames test revealed no sign of mutagenicity at any concentration tested. Its FTIR spectrum coupled with the positive Liebermann?Burchard, Salkowski and Zak color reactions (tests) indicated the presence of sterol compounds.Discussion and conclusion: The screened extract may inspire a search for novel anticholinesterase therapeutic agent(s) potentially used in the treatment of Alzheimer's disease. Further research will be directed toward its detailed chemical analysis along with addressing the issue of a real producer of the natural product(s) responsible for the AChE activity observed.

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STEROLS AND VOLATILE COMPOUNDS OF THE FRESHWATER SPONGETROCHOSPONGILLA PAULULA(BOWERBANK, 1863)

Cited by 2 publications

References 0 publications

Trends and Gaps in Scientific Production on Freshwater Sponges

Trends and Gaps in Scientific Production on Freshwater Sponges

Further insight into the bioactivity of the freshwater sponge Ochridaspongia rotunda

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