2016
DOI: 10.5935/0034-7280.20160061
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Platelet-rich plasma in diabetic dry eye disease

Abstract: Objetivo: Avaliar a eficácia do colírio de concentrado de plaquetas (CCP) autólogo no olho seco sintomático de pacientes diabéticos. Projeto: Um estudo de intervenção único grupo prospectivo. Participantes: Doze pacientes diabéticos com doença do olho seco refratário. Métodos: Os pacientes foram tratados com colírio de PRP autólogo quatro vezes por dia durante um mês. Sintomas de olho seco e sua frequência, seguindo os critérios de DEWS, tempo de ruptura do filme lacrimal, a melhoria das linhas de acuidade vis… Show more

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Cited by 9 publications
(5 citation statements)
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“…In keeping with the literature, 8 , 21 , 34 , 35 we found a significant improvement in f/a NIBUT and TMH scores. PRP contains a high concentration of epitheliotropic growth factors including platelet-derived growth factor, fibroblast growth factor, epidermal growth factor, fibronectin, and platelet factor IV that target a variety of cells, including conjunctival goblet cells.…”
Section: Discussionsupporting
confidence: 91%
“…In keeping with the literature, 8 , 21 , 34 , 35 we found a significant improvement in f/a NIBUT and TMH scores. PRP contains a high concentration of epitheliotropic growth factors including platelet-derived growth factor, fibroblast growth factor, epidermal growth factor, fibronectin, and platelet factor IV that target a variety of cells, including conjunctival goblet cells.…”
Section: Discussionsupporting
confidence: 91%
“…The all-inclusive score had a range of 0 to 100, with a cut-off value of 12 (positive for DED if the score is ≥13). DED could then be classified as mild (from 13 to 22), moderate (23)(24)(25)(26)(27)(28)(29)(30)(31)(32), and severe (≥ 33) based on the scores obtained (21).…”
Section: Methodsmentioning
confidence: 99%
“…PRP becomes more effective when presenting higher indexes of growth factors such as epithelial growth factor (EGF), vitamin A, neural growth factor (NGF), insulin type I growth factor,[ 19 ] and platelet factor IV. [ 20 ] PRP is a preservative-free biological product from the patient’s own blood having a platelet concentration above baseline. The main advantage of PRP over other products is the presence of the platelets and the prolonged release of growth factors that are involved in the wound-healing process of the cornea and conjunctival surface.…”
Section: Discussionmentioning
confidence: 99%