The role of Descemet’s membrane in the pathogeny of corneal edema following anterior segment surgery

Aim: This study involves, for the first time, the development of mucoadhesive biodegradable polymeric-multilayered nanoparticles-in-nanofibers (NPs-in-NFs) matrix as an innovative single-dose noninvasive ocular-insert that could substitute conventional ocular dosage-forms. Materials & methods: Azithromycin-loaded poly(lactic-co-glycolic acid) copolymer/pluronic NPs were developed then incorporated into electrospun polyvinylpyrrolidone NFs, and tested for their efficient treatment of ocular bacterial infection. Results: Release and permeation studies proved the ability of the insert to control drug release over 10 days. Conclusion: The incorporation of NPs into NFs achieved several other benefits like increasing ocular residence and contact time with conjunctival tissue, accurate dose delivery, sustaining drug release with constant rate, reducing frequency of administration, improving bioavailability along with decreasing incidence of visual and systemic side effects.

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Noninvasive Biodegradable Nanoparticles-in-Nanofibers Single-Dose Ocular Insert: In Vitro , Ex Vivo and In Vivo Evaluation

Khalil

Ali

El‐Sherbiny

2018

Nanomedicine (Lond.)

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The role of Descemet’s membrane in the pathogeny of corneal edema following anterior segment surgery

Abstract: Instituição onde o trabalho foi realizado: Banco de olhos do Estado do Ceará, Brasil

Cited by 1 publication

References 17 publications

Noninvasive Biodegradable Nanoparticles-in-Nanofibers Single-Dose Ocular Insert: In Vitro , Ex Vivo and In Vivo Evaluation

Noninvasive Biodegradable Nanoparticles-in-Nanofibers Single-Dose Ocular Insert: In Vitro , Ex Vivo and In Vivo Evaluation

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