Effect of the bioprotectant agent trehalose on corneal epithelial healing
                        after corneal cross-linking for keratoconus

Özek, Dilay; Kemer, Özlem Evren

doi:10.5935/0004-2749.20180100

Cited by 12 publications

(11 citation statements)

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“…In the present study, it was investigated Trehalose's effect on corneal epithelial healing after phacoemulsification surgery. It has a similar impact on corneal epithelial healing to previous studies (Takeuchi et al, 2010;Takeuchi et al, 2011;Mateo Orobia et al, 2017;Ozek et al, 2018). Oxford staining score, which is used for corneal cellular viability, was higher after surgery and epithelial healing was faster in the trehalose group but not statistically significant.…”

Section: Discussionsupporting

confidence: 71%

“…Epithelial healing was significantly faster in the patients who had received Trehalose for cross-link treatment when compared to sodium hyaluronate only. However, in this study, there was no information about the stromal effect of Trehalose (Ozek et al, 2018). In the present study, it was investigated Trehalose's effect on corneal epithelial healing after phacoemulsification surgery.…”

Section: Discussionmentioning

confidence: 90%

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Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Erdoğan

Muhsinoglu

2021

Black Sea Journal of Health Science

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This study aimed to evaluate the efficacy of hyaluronic acid/trehalose drop for corneal epithelial and stromal healing after phacoemulsification surgery. It is a retrospective randomized comparative study. The patients had phacoemulsification surgery divided into two groups. These patients received either a mixture of sodium hyaluronate and Trehalose (Group 1) or sodium hyaluronate 0.15% (Group 2) postoperatively. The effect on corneal epithelial and stromal healing was evaluated using Oxford staining and the vertical scar length measured by optical coherence tomography. Preoperative and post-operative findings for Oxford staining, Schirmer's test, tear film break-uptime, and ocular surface disease index scores were also evaluated. The correlation between scar length and tear film parameters was examined. The effect of Trehalose on the epithelial healing and stromal scar formation was assessed. Group 1 and 2 each had 30 eyes. The two groups were similar according to age and sex distribution. In terms of epithelial healing, it was faster in the trehalose group, although there was no statistical difference between the two groups. The length of the stromal scar was not significantly different between groups. However, a smaller scar formation was observed in group 1 compared to those in group 2 at both one week and one month postoperatively. There was also no significant difference between the groups in tear film parameters. The stromal scar length was correlated with the Schirmer test on the 15th day. Although it was not statistically significant, the hyaluronic acid/trehalose may affect epithelial healing and stromal scar formation positively after phacoemulsification surgery. Larger and longer studies are needed.

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Section: Discussionsupporting

confidence: 71%

Section: Discussionmentioning

confidence: 90%

Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Erdoğan

Muhsinoglu

2021

Black Sea Journal of Health Science

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“…[ 108 109 110 ] Trehalose is available in combination with sodium hyaluronate as eye drops and its use has been well-documented in dry eyes and KC. [ 110 111 ] It shows potential in improving epithelial healing post CXL[ 112 ] and slowing down the progression of KC before CXL but needs larger studies.…”

Section: O Xidative S Tress M ...mentioning

confidence: 99%

Biochemical and molecular alterations and potential clinical applications of biomarkers in keratoconus

et al. 2022

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“…Los estudios clínicos en los que se instiló trehalosa tópica al 3% en pacientes con síndrome de ojo seco han demostrado una mejoría significativa en la estabilidad de la película lagrimal y la tinción ocular 12,13 , así como después del procedimiento denominado crosslinking, en el que algunas de sus variedades incluyen la desepitelización corneal y se observa una regeneración más rápida de esta 14 .…”

Section: Introductionunclassified

Efecto de la trehalosa tópica al 3% en la velocidad de epitelización corneal en pacientes operados de queratectomía fotorrefractiva

Haber¹,

Polania-Baron²

2021

Revista Mexicana De Oftalmología

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Estudiar el cambio en la velocidad de epitelización corneal en pacientes sometidos a cirugía de queratectomía fotorrefractiva de superficie en los que se aplicó trehalosa al 3%. Método: Se trata de un ensayo clínico prospectivo, aleatorizado y controlado. Los criterios de inclusión fueron ser mayor de 18 años, con criterios clínicos y topográficos para realizar cirugía refractiva, y aceptar participar en el protocolo. La asignación aleatoria se llevó a cabo para asignar a uno de los dos ojos de cada paciente para conformar el grupo control con el tratamiento convencional y el grupo de tratamiento con la instilación, además del tratamiento convencional, de trehalosa al 3%. Para cuantificar el área de desepitelización en milímetros cuadrados se utilizó el software libre de procesamiento de imágenes Image J. Resultados: El promedio de días de epitelización en el grupo de casos fue de 2.984 días y en el grupo de control fue de 2.954 días (diferencia no estadísticamente significativa; p = 0.1624063). El área de desepitelización en la revisión previa a alcanzar el 100% de epitelización en el grupo de casos fue de 4.255 mm 2 y en el grupo de control fue de 3.1762 mm 2 (diferencia no estadísticamente significativa; p = 0.0899374). Conclusiones: La trehalosa tópica al 3% no aumenta la velocidad de epitelización corneal en pacientes sometidos a queratectomía fotorrefractiva.

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Effect of the bioprotectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus

Cited by 12 publications

References 0 publications

Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Effect of Postoperative Administration of Hyaluronic Acid/Trehalose Drop on Corneal Healing After Phacoemulsification Surgery

Biochemical and molecular alterations and potential clinical applications of biomarkers in keratoconus

Efecto de la trehalosa tópica al 3% en la velocidad de epitelización corneal en pacientes operados de queratectomía fotorrefractiva

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