DRESS syndrome in ophthalmic patients

Sousa, Jacqueline Martins de; Nascimento, Heloísa; Belfort, Rubens

doi:10.5935/0004-2749.20160055

Cited by 4 publications

(3 citation statements)

References 8 publications

(27 reference statements)

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“…Ocular toxoplasmosis also stands out as the most common cause of posterior uveitis, which mainly affects the retina and its underlying layer, causing focal necrotizing retinochoroiditis, which is characterized by pigmented macular lesions with necrotic spots on the retina (Lie et al, 2019). It appears that there are no antiparasitic agents capable of eradicating T. gondii from ocular tissues, and the most commonly used treatment, pyrimethamine plus sulfadiazine and folinic acid, still has questionable efficacy and can often cause more problems than the disease itself, such as provoking DRESS syndrome (Cárrion-Cárrion et al, 1999;Kim et al, 2002;Oliveira, 2012;Schallhorn & Gonzales, 2013;Sousa et al, 2016;Velter et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Profile of adverse events in toxoplasmosis drug therapy: a review

Sousa

Viana

Caires

et al. 2021

RSD

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This study aims to analyze the profile of adverse events (AEs) of drugs for the treatment of Toxoplasmosis. This is a review carried out through a bibliographic search in the electronic databases PubMed, SciELO, Cochrane Digital Library and LILACS. The keywords “Toxoplasmosis” AND “Drug Therapy” AND “Drug-Related Side Effects and Adverse Reactions” were used. The selection was performed by two independent reviewers and the articles were included considering the presence of retrospective studies and case reports published in the literature in Portuguese and English and without time restrictions. In total, 40 articles were found, of which 14 met the inclusion criteria. Cases of cerebral, ocular, gestational and congenital Toxoplasmosis were identified. Among these, we observed a total of 85 patients with reports of AEs due to the use of Pyrimethamine, Sulfadiazine, Spiramycin, Clindamycin, Atovaquone, Trimethoprim and Sulfamethoxazole and Sulfadoxine. Clinical reactions were in the form of skin rash (57.1%), hematological alterations (28.5%), Lyell syndromes (7.1%), Stevens-Johnson (21.4%) and DRESS (21 .4%). The prevalence of AEs related to hematological alterations was seen mainly in treatments based on Pyrimethamine + Sulfadiazine, Trimethoprim and Sulfamethoxazole; on the other hand, those associated with severe syndromes are often related to the use of Pyrimethamine + Sulfadiazine. It is important to establish a standard protocol for drug therapy for Toxoplasmosis, which does not yet exist. In addition, the need to monitor patients after drug administration is highlighted, given the possibility of the occurrence of adverse events that can represent a threat to life.

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Section: Resultsmentioning

confidence: 99%

Profile of adverse events in toxoplasmosis drug therapy: a review

Sousa

Viana

Caires

et al. 2021

RSD

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“…Patch and lymphocyte transformation testing might help to identify the drug, but neither is widely used or accepted. 11,12 This article adds to the scarce reports describing psychotropic-drug-induced DRESS, along with the subsequent clinical-psychiatric management and a safe trial on quetiapine and nortriptyline. The report emphasizes the need for awareness about this rare yet potentially life-threatening drug reaction.…”

Section: Drug Reaction With Eosinophilia and Systemic Symptoms (Dress) Syndrome In A Patient With Bipolar Disorder: A Case Reportmentioning

confidence: 98%

“…Patch and lymphocyte transformation testing might help to identify the drug, but neither is widely used or accepted. 11,12…”

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confidence: 99%

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient with Bipolar Disorder: A Case Report

Gupta

Pattanayak

Khandelwal

et al. 2021

Indian Journal of Psychological Medicine

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Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

Sharifzadeh

Mohammadpour

Tavanaee

et al. 2020

Eur J Clin Pharmacol

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Background Drug reaction with eosinophilia and systemic symptoms syndrome (DRESS) is a delayed infrequent potentially lifethreatening idiosyncratic drug reaction. Aromatic anticonvulsants and allopurinol are the most frequent causative agents. However, various reports of antibiotic-induced DRESS are available. In this review, we try to summarize reports of antibacterial antibiotic-induced DRESS focusing on characteristics of DRESS induced by each antibiotic group. Methods The data were collected by searching PubMed/MEDLINE and ScienceDirect. The keywords used as search terms were "DRESS syndrome," "drug-induced hypersensitivity syndrome (DIHS)," "antibiotics," "antimicrobial," and names of various antimicrobial groups. Finally, 254 relevant cases with a definite or probable diagnosis of DRESS based on RegiSCAR criteria were found until 30 May 2020 and reviewed. Results and conclusion Totally, 254 cases of antibacterial antibiotic-induced DRESS are reported. Most of them are related to antituberculosis drugs, vancomycin, and sulfonamides, respectively. Rash and fever were most frequent clinical findings. Eosinophilia and liver injury were the most reported hematologic and visceral organ involvement, respectively. Most of the patients are managed with systemic corticosteroids. The death occurred in 16 patients which most of them experienced liver or lung involvement. The reactivation of various viruses especially HHV-6 is reported in 33 cases. The mean latency period was 29 days. It is necessary to perform thorough epidemiological, genetic, and immunological studies, also systematic case review and causality assessment, as well as well-designed clinical trials for better management of antibiotic-induced DRESS.

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DRESS syndrome in ophthalmic patients

Cited by 4 publications

References 8 publications

Profile of adverse events in toxoplasmosis drug therapy: a review

Profile of adverse events in toxoplasmosis drug therapy: a review

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) Syndrome in a Patient with Bipolar Disorder: A Case Report

Antibacterial antibiotic-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome: a literature review

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